back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIA2 and Nmdar2

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster

Alignment Length:	987	Identity:	235/987 - (23%)
Similarity:	389/987 - (39%)	Gaps:	254/987 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     7 ISVLLSPVLWGLIFGV-SSNSIQI---GGLFPRGADQEYSAFRVGMV----QFSTSEF------- 56
            ||:||..||..||... |...:::   ||...:||........:|::    .|...|:
  Fly    60 ISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNA 124

Human    57 ----------RLT-----------PHIDNLEVANS-FAVTNAFCSQFSR-GVYAI--------FG 90
                      :||           .|.|.:.:..| .|:.:..|.:|.| .|.||        ||
  Fly   125 VTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFG 189

Human    91 FYDKKSVNTITSFCGTLHVSFITPSFPTDGTH------PFVIQMRPDLK---GALLSLIEYYQWD 146
             :...|........|.|.:..|:.:....|..      ...:|:.|.::   .|:||::|.|:|.
  Fly   190 -HSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWH 253

Human   147 KFAYLYDSDRGLST-LQAVLDSAAE--KKWQVTAINVGNINNDKKDEMYRSLFQDLEL-KKERRV 207
            :|:.:.....|... :|||.:..||  :.::.|.:|  :|...:..::       :|| ..|.||
  Fly   254 QFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILN--SIVVTRTSDL-------MELVNSEARV 309

Human   208 ILDCERDKVNDIVDQVITI---GKHVK--GYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDD 267
            :|      :.....:.|||   .:.:|  |.:|:
  Fly   310 ML------LYATQTEAITILRAAEEMKLTGENYV------------------------------- 337

Human   268 SLVSKFIERWSTLEEK----EYP----GAHTTTIKYTSALTYD---AVQVMT---EAF------- 311
                 ::...|.:|:|    ::|    |.|..|  .::||..:   |:::.:   ||:
  Fly   338 -----WVVSQSVIEKKDAHSQFPVGMLGVHFDT--SSAALMNEISNAIKIYSYGVEAYLTDPANR 395

Human   312 -RNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEG--LSGNIKFDQNGKRINYTI 373
             |.|..|.:.....|..         .|..|....:.|:.|.:||  ...||:|..:|...:..:
  Fly   396 DRRLTTQSLSCEDEGRG---------RWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAEL 451

Human   374 NIMELKTNGPRK------IGYWS--EVDKMVVTLTELPSGND---TSGLENK-TVVVTTILESPY 426
            .||.|:.:...|      ||.|.  |..|:.:.....| ||.   ..|:..| .:.:|.:.|:||
  Fly   452 KIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWP-GNSHAPPQGVPEKFHLKITFLEEAPY 515

Human   427 VMMK--------------------KNHEM--------LEGNERY----EGYCVDLAAEIAKHCGF 459
            :.:.                    .:|||        ...||.:    .|:|:||..:.|:..||
  Fly   516 INLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGF 580

Human   460 KYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIM 524
            .|:|..|.|||:|.  .:...|||::.:||..|.|:.:..|.|...||.|:|||:|||..||:|:
  Fly   581 TYELVRVEDGKWGT--LENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIV 643

Human   525 IKKPQKSKPGVFS---FLDPLAYEIWMCI-VFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQS 585
            :.|    :.|:.|   ||:|.....||.: :.|....:.::||....||..:..:.:
  Fly   644 VAK----RTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLY-------- 696

Human   586 SESTN----EFGIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF- 644
            .::||    .|.:|.:.|.......|....: |||..:.|.:..||..|.::.::.||||||||
  Fly   697 LQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFM 761

Human   645 -----------LTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSA 698
                       |...|:|.|      .|.:....:||:....|.....:    .|:.|..|||..
  Fly   762 ITREEFHEFSGLNDSRLVHP------FSHKPSFKFGTIPYSHTDSTIHK----YFNVMHNYMRQY 816

Human   699 EPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEY-IEQRKPCDTMKVGGNLDSKGYGIATPKGSS 762
            ..:    :.|:|||.|... ...:::.:.|:.:| :.|.:.|..|.||......|||:|..:.|.
  Fly   817 NKT----SVADGVAAVLNG-NLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSK 876

Human   763 LRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSA--LSLSNVAGVFYILVGGLG 825
            .....|..:|:....|.|::|:..|.  .|.|   ..|.:|..|:  |:|......|.:|:.|:.
  Fly   877 YVQMFNKRLLEFRANGDLERLRRYWM--TGTC---RPGKQEHKSSDPLALEQFLSAFLLLMAGIL 936

Human   826 LAMLVALIEFCY 837
            ||.|:.|:|..|
  Fly   937 LAALLLLLEHVY 948

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.