DRSC/TRiP Functional Genomics Resources

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Protein Alignment GRIA2 and Ir41a

DIOPT Version :9

Sequence 1:NP_000817.5 Gene:GRIA2 / 2891 HGNCID:4572 Length:883 Species:Homo sapiens
Sequence 2:NP_995744.4 Gene:Ir41a / 2768714 FlyBaseID:FBgn0040849 Length:648 Species:Drosophila melanogaster


Alignment Length:708 Identity:139/708 - (19%)
Similarity:234/708 - (33%) Gaps:207/708 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   221 DQVITIGKHVK-----GYHYIIANLG-----------FTDGDLLK--IQFGGANVSGFQIVDYD- 266
            |.:..:|.::|     |.|||| :.|           |.|..::|  |.....:...|.:.|.| 
  Fly    41 DYISFVGINIKSFDDNGGHYII-DTGLKKKELQNKHLFLDELVIKIIISIEVTHCETFVVFDKDI 104

Human   267 DSLVSKFIER-----WSTLEEK-------------------EYPGAHTTTIKYTSALTYDAVQVM 307
            |..|:.|.:.     |.:|..|                   :.|........::||.::|   :.
  Fly   105 DRFVNAFNKASVYSIWRSLHNKFVFAHIANESPESRNHFFEDQPNILFVVRDHSSASSFD---IK 166

Human   308 TEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYT 372
            |..|         :.|:..      ||:    |.:.::|.|...|        :| |.||.:   
  Fly   167 TNKF---------VGRKAE------NPS----QMILVDRYLASEQ--------RF-QFGKSL--- 200

Human   373 INIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKN----- 432
                              ..||:             :.|:.:.|::......||.::|.|     
  Fly   201 ------------------FADKL-------------NNLQGREVIIAGFDYPPYTVIKHNMSTNA 234

Human   433 HEM-LEGNERYEGYCVD-LAAEIAKHCGFKYKLTIVGDGKYGARDADTKIW---------NGMVG 486
            .:| :.|...::...:| ....|..:...::..||..|.. .|.|     |         :|.:|
  Fly   235 QDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDSS-AAND-----WGKVYPNMSGDGALG 293

Human   487 ELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIV 551
            .|:..||||.|..:.........:|.|...:..||:.::..|.:....... |:|....:|..|:
  Fly   294 MLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLP-LEPFKETLWAAIL 357

Human   552 FAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRS 616
            ......:..|.|..:.....:....:.:|..|.:|     ||:..:  |.|  |:.|..:....|
  Fly   358 LCLCAEATGLVLAYKSEQALYVLPGYREGWWTCTS-----FGVCTT--FKL--FISQSGNSKAYS 413

Human   617 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFR 681
            |:.|::....:...|||.|.|...||:.||:..|   .|:|:.:               |:..|.
  Fly   414 LTVRVLLFACFLNDLIITSIYGGGLASILTIPSM---DEAADTV---------------TRLRFH 460

Human   682 RSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAY----LLESTMNEYIE-----QRK 737
            |.:.|...:.|.....|.....|:......         :.|    ||....::::.     :|.
  Fly   461 RLQWAANSEAWVSAIRASDEALVKDILYNF---------HIYSDDELLRLAQDQHMRIGFTVERL 516

Human   738 PCDTMKVGGNLDSKG--------------YGIA-TPKGSSLRTPVNLAVLKLSEQG--------- 778
            |.....:|..|..:.              |.:| .|:...|...:|..:......|         
  Fly   517 PFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGFDKYWEYRV 581

Human   779 VLDKLKNKWWYDKGE--CGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIE 834
            |.|.|..|......|  .|.||.|    ...|.:||.||...:.:.|..:|.|..|:|
  Fly   582 VADNLNLKIQQQVQETMTGTKDIG----PVPLGMSNFAGFIIVWILGSAIATLTFLLE 635

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GRIA2NP_000817.5 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612 41/219 (19%)
PBP2_iGluR_AMPA 413..794 CDD:270433 83/431 (19%)
Glutamate binding 499..501 0/1 (0%)