Protein Alignment GRIA2 and Ir41a

DIOPT Version :10

• Sequence 1: NP_000817.5
• Gene: GRIA2 / 2891
• HGNCID: 4572
• Length: 883
• Species: Homo sapiens
• Sequence 2: NP_995744.4
• Gene: Ir41a / 2768714
• FlyBaseID: FBgn0040849
• Length: 648
• Species: Drosophila melanogaster
• Alignment Length: 708
• Identity: 139/708 - (19%)
• Similarity: 234/708 - (33%)
• Gaps: 207/708 - (29%)

Human   221 DQVITIGKHVK-----GYHYIIANLG-----------FTDGDLLK--IQFGGANVSGFQIVDYD- 266
            |.:..:|.::|     |.|||| :.|           |.|..::|  |.....:...|.:.|.|
  Fly    41 DYISFVGINIKSFDDNGGHYII-DTGLKKKELQNKHLFLDELVIKIIISIEVTHCETFVVFDKDI 104

Human   267 DSLVSKFIER-----WSTLEEK-------------------EYPGAHTTTIKYTSALTYDAVQVM 307
            |..|:.|.:.     |.:|..|                   :.|........::||.::|   :.
  Fly   105 DRFVNAFNKASVYSIWRSLHNKFVFAHIANESPESRNHFFEDQPNILFVVRDHSSASSFD---IK 166

Human   308 TEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYT 372
            |..|         :.|:..      ||:    |.:.::|.|...|        :| |.||.:
  Fly   167 TNKF---------VGRKAE------NPS----QMILVDRYLASEQ--------RF-QFGKSL--- 200

Human   373 INIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKN----- 432
                              ..||:             :.|:.:.|::......||.::|.|
  Fly   201 ------------------FADKL-------------NNLQGREVIIAGFDYPPYTVIKHNMSTNA 234

Human   433 HEM-LEGNERYEGYCVD-LAAEIAKHCGFKYKLTIVGDGKYGARDADTKIW---------NGMVG 486
            .:| :.|...::...:| ....|..:...::..||..|.. .|.|     |         :|.:|
  Fly   235 QDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDSS-AAND-----WGKVYPNMSGDGALG 293

Human   487 ELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIV 551
            .|:..||||.|..:.........:|.|...:..||:.::..|.:....... |:|....:|..|:
  Fly   294 MLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLP-LEPFKETLWAAIL 357

Human   552 FAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRS 616
            ......:..|.|..:.....:....:.:|..|.:|     ||:..:  |.|  |:.|..:....|
  Fly   358 LCLCAEATGLVLAYKSEQALYVLPGYREGWWTCTS-----FGVCTT--FKL--FISQSGNSKAYS 413

Human   617 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFR 681
            |:.|::....:...|||.|.|...||:.||:..|   .|:|:.:               |:..|.
  Fly   414 LTVRVLLFACFLNDLIITSIYGGGLASILTIPSM---DEAADTV---------------TRLRFH 460

Human   682 RSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAY----LLESTMNEYIE-----QRK 737
            |.:.|...:.|.....|.....|:......         :.|    ||....::::.     :|.
  Fly   461 RLQWAANSEAWVSAIRASDEALVKDILYNF---------HIYSDDELLRLAQDQHMRIGFTVERL 516

Human   738 PCDTMKVGGNLDSKG--------------YGIA-TPKGSSLRTPVNLAVLKLSEQG--------- 778
            |.....:|..|..:.              |.:| .|:...|...:|..:......|
  Fly   517 PFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSGFDKYWEYRV 581

Human   779 VLDKLKNKWWYDKGE--CGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIE 834
            |.|.|..|......|  .|.||.|    ...|.:||.||...:.:.|..:|.|..|:|
  Fly   582 VADNLNLKIQQQVQETMTGTKDIG----PVPLGMSNFAGFIIVWILGSAIATLTFLLE 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA2	NP_000817.5	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	41/219 (19%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	83/431 (19%)
		Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491	867..877
Ir41a	NP_995744.4	None