DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIA1 and KaiR1D

DIOPT Version :9

Sequence 1:	NP_001244950.1	Gene:	GRIA1 / 2890	HGNCID:	4571	Length:	916	Species:	Homo sapiens
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	840	Identity:	329/840 - (39%)
Similarity:	503/840 - (59%)	Gaps:	63/840 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    36 EVWGLFPNQQSQEHAAFRFALSQLTEPPKLLP------QIDIVNISDSFEMTYRFCSQFSKGVYA 94
            ::.|||......:..|||.|:.::.....:||      ||:.::..|||....|.|...:.||.|
  Fly    31 KIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGVAA 95

Human    95 IFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPE------------LQDALISII 147
            |||.....|.:.:.|.|..:.:..:        .|::..:||.|            |..|.:.|:
  Fly    96 IFGPQSSHTASHVQSICDNMEIPHL--------ENRWDYRLRRESCLVNLYPHPNTLSKAYVDIV 152

Human   148 DHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEG-YRMLFQDLEKKKERLVV 211
            .|:.|:.|..||:.:.|:..||::|.......:.:|   :...::.| ||.|.:.::...|..:|
  Fly   153 RHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPIT---VRQLSDSGDYRPLLKQIKNSAEAHIV 214

Human   212 VDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKI 276
            :||.:||::.:|.|..::......:.|::.:|....::|::|:..|.|:|||:|:|  :.|.:.:
  Fly   215 LDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLIN--EKIVSDV 277

Human   277 MQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSL-RRQRIDISRRGNAGDCLANPAVP 340
            ::||...:.......:....:..:||.||.|.:.|:|...| ..|:|||......|..      .
  Fly   278 VRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQS------T 336

Human   341 WGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNE--DDKFVPAAT 403
            |..|..:...::.|..:|||..::|:.:|.||::.|.::|:...||||||.||.  .|......|
  Fly   337 WQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWNSTLPDGINFTRT 401

Human   404 DAQAGGD-NSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLE 467
            .:|...: .::::|:|.:|||||.:||.|.|::|....|||::|||.|:|..||:|.:|::|:::
  Fly   402 FSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQ 466

Human   468 IVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 532
            :|.||.||:.:..|..||||:.||:..|||:|:|.||||..||:.:||:.|||:||:||:.:||.
  Fly   467 LVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPI 531

Human   533 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW------HSEEFEEGRDQTTSDQ 591
            |..|.:||||.||:.::|:.:..||:||||:||::::|:||||      |.|:.|
  Fly   532 KQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAHGEKVE---------- 586

Human   592 SNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP 656
             ::|.:.|.:||::|:.||||||..|::||.|:|.|:|||||||:|||||||||||||||||.||
  Fly   587 -SQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSP 650

Human   657 IESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSK 721
            |||||||||||.|.||.|:.|||..|||.|||:.:::||::|:||.||||..:..||:.||.|.|
  Fly   651 IESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKGK 715

Human   722 GKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKL 786
            |.||:|:|||..||:.:|. |:..:|||.||:|.||||||..|..|..:|..:|||.|:|.|..|
  Fly   716 GSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHIL 779

Human   787 KNKWWYDK---GECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSR 843
            |.|||.:|   |:|......|....:.|.|:||.|||.:|:||:|:|.::|:.||.:|||
  Fly   780 KTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSR 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..399	CDD:107385	102/384 (27%)
		ANF_receptor	47..382	CDD:279440	90/354 (25%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	205/389 (53%)
		Lig_chan	548..827	CDD:278489	149/287 (52%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	102/384 (27%)
		ANF_receptor	42..378	CDD:279440	90/354 (25%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	202/381 (53%)
		Lig_chan	547..823	CDD:278489	149/287 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820