Protein Alignment GRIA1 and Ir60a

DIOPT Version :10

• Sequence 1: NP_001244950.1
• Gene: GRIA1 / 2890
• HGNCID: 4571
• Length: 916
• Species: Homo sapiens
• Sequence 2: NP_611901.1
• Gene: Ir60a / 37881
• FlyBaseID: FBgn0034994
• Length: 716
• Species: Drosophila melanogaster
• Alignment Length: 553
• Identity: 99/553 - (17%)
• Similarity: 177/553 - (32%)
• Gaps: 204/553 - (36%)

Human   211 VVDCESERLNAILGQIIKLE------KNGIG---------------------YHYILANLGFMDI 248
            :|:..:|..|.::..:.:.:      |.|:|                     |:.:|.:...:..
  Fly    24 IVNLSNETANTVIFMLPEKDLGPDVWKAGVGCLDSFAQIFFFRNPKERFTRAYNLMLVHAFHLSS 88

Human   249 DLNKFKESGANVTGF-QLVNYTDTIPA-----KIMQQWKNSDARDHTRVDWKRPKYTSALTYDGV 307
            ..::.:|      || :|:|...|.|.     ::.|....||.           ..|:.....|.
  Fly    89 PADQIQE------GFSKLINEAVTNPGPPDREELFQMRVASDY-----------NITNGTEDKGE 136

Human   308 KVMAEAF----------QSLRRQRIDISRRGNAGD---CLANPAV----PWGQGIDIQRALQQVR 355
            .::|:.:          :.|.:::|...|..|.|.   .|.:.|.    |.|...:|.:.|.::.
  Fly   137 LILADNYVIVVDSVDRLKELMKKKIVEMRSWNPGARFLVLFHNATCRNRPLGVASNIFKDLMEMF 201

Human   356 FEGLTGNVQFNEKGRRTNYTLHV------IEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDN--- 411
            :......:..|.   ..||.|.|      :..:...::.:|..: |.|..|.....:|...:
  Fly   202 YVHRVALLYANS---TMNYNLLVNDYYSNVNCRILNVQSVGQCH-DGKLYPNNAVVKASMQDYVS 262

Human   412 -SSVQNRTYIVTTILEDPYV------------------MLKKNANQ---------FEGNDRYEGY 448
             .|.:|.|:...:.:..|:|                  .||.:.||         .:|...:.|.
  Fly   263 GFSPRNCTFFACSSISAPFVEADCILGLEMRILGFMKNRLKFDVNQTCSLESRGEMDGPANWTGL 327

Human   449 CVELAAEIAKHV--GYSYRLEIVSDGKYGA----RDPDT---------KAWNGMVG--------- 489
            ..::.......|  || |....|:|..:|:    :|..|         .||..:||
  Fly   328 LGKVQNNECDFVFGGY-YPDNEVADHFWGSDTYLQDAHTWYIKMADRRPAWQALVGIFEAYTWIG 391

Human   490 -------ELVYGRADVAVAP-------LTITLVREEVIDFS-----KP--------FMSL---GI 524
                   ..::....|.:.|       |::|.:....:..|     :|        ||:|   |:
  Fly   392 FILILIISWLFWFTLVMILPEPKYYQQLSLTAINALAVTISIAVQERPICETTRLFFMALTLYGL 456

Human   525 SIMIKKPQK-----SKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGR 584
            :::.....|     ..||....||.|..     :|.|.|             |:..|    ||.|
  Fly   457 NVVATYTSKMIATFQDPGYLHQLDELTE-----VVAAGI-------------PFGGH----EESR 499

Human   585 DQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISP 617
            |...:|  ::..|||            |.:|||
  Fly   500 DWFEND--DDMWIFN------------GYNISP 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..402	CDD:380613	41/246 (17%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	56/288 (19%)
Ir60a	NP_611901.1	None