Protein Alignment GRIA1 and GluRIIB

DIOPT Version :10

• Sequence 1: NP_001244950.1
• Gene: GRIA1 / 2890
• HGNCID: 4571
• Length: 916
• Species: Homo sapiens
• Sequence 2: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Alignment Length: 869
• Identity: 245/869 - (28%)
• Similarity: 406/869 - (46%)
• Gaps: 96/869 - (11%)

Human    36 EVWGLFPNQQSQEHAAFRFALSQLT--EPPKLLPQID-IVNISDSFEMTYRFCSQFSKGVYAIFG 97
            ::..:|.:.:.:...||..||.::.  .|...|..|. .|.:.||..:....|.....||.||||
  Fly    26 KIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVTVDDSIVLQDISCDLIGSGVAAIFG 90

Human    98 FYERRT---VNMLTSFCGALHVCFITPSFPVDTSN------QFVLQLRP-EL------QDALISI 146
            ...:..   |.:|.:..|..|:.|   .:....||      |..:.:.| ||      .|.|.|
  Fly    91 PSSKTNSDIVEVLCNMTGIPHLQF---DWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILAS- 151

Human   147 IDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEG--YRMLFQDLEKKKERL 209
             ..:.|:.|...|:....|..||.:|   |.|......:. :...|.|  ||:|::.:...:|:.
  Fly   152 -KTFDWKSFTIAYERSSHLIRLQHIL---AWKQLHKAGIK-MQEFERGDDYRILWKRINNAREKF 211

Human   210 VVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPA 274
            |::||.|:.|..::...|.....|...|..|.||   |..|       :.:.||...::|..:.|
  Fly   212 VLLDCPSDILVDVINASIGYNMTGSFNHLFLTNL---DTHL-------SGIDGFYSRDFTVAVAA 266

Human   275 KIMQQWKNSDARDH-----TRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCL 334
            ..::.:......|.     ..||.:.....|.|.||.:.:...|.       ::||:|  .|..:
  Fly   267 VRIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNAL-------LEISQR--PGFYI 322

Human   335 ANPAVP---WGQGIDIQRALQQVR-------FEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKI 389
            .|.:..   |..|..:...::|:.       |:  |..:|.|..|:|.::.|.|.....|.:..|
  Fly   323 PNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFK--TQRLQINADGQREDFNLEVYNPIIDRVTHI 385

Human   390 GYWNEDDKFVPAATDAQAGGDNSS-------VQNR--------TYIVTTILEDPYVMLKKNAN-- 437
              ||::.:.|    |.:...:||:       :||:        .|.|.|.:..||...::...
  Fly   386 --WNKEFQLV----DFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGV 444

Human   438 QFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAP 502
            .:|||:|:|||.|:|...:|:...:.:..|.|.|.|||:.|.:|..|:|::.:|:...|.:.:..
  Fly   445 HYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICD 509

Human   503 LTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 567
            ||||..|..|:||:.|||.|||||:..|....|..:::||:|...|:|:.::.|.:..:..|...
  Fly   510 LTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFT 574

Human   568 SRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFF 632
            .|...|||........|:.   ::.|.:.:.|:||..||:.:.||||:.||.|..|::...||.|
  Fly   575 GRIDQYEWDQPVENVNREM---ERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIF 636

Human   633 TLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTY 697
            .|:|..:|.|.||||:|..::...|.|..||..|.::.:||:..|:|..:|..|........|..
  Fly   637 ALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNK 701

Human   698 MKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPK 762
            |.|.:|..|.:..|||:.||:.|||.||:|:|:|..:|..||. |:..::|.:...|.||||.|.
  Fly   702 MLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRN-CELTQIGESFGEKHYGIAVPL 765

Human   763 GSALRNPVNLAVLKLNEQGLLDKLKNKWW-YDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGG 826
            .:..|:.:::.:|:|:|:|.|.||:|||: .::..|.|......|  ....:.:|.|:|.:||.|
  Fly   766 NADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDD--GQFDMDSVGGLFVVLIVG 828

Human   827 LGLAMLVALIEFCYKSRSESKRMK 850
            :.:.:::.:.||.:..:..|.:.|
  Fly   829 VVVGLVIGVAEFLWHVQRISVKEK 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..402	CDD:380613	93/401 (23%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	135/391 (35%)
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	90/392 (23%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	134/376 (36%)