Protein Alignment GRIA1 and GluRIIC

DIOPT Version :10

• Sequence 1: NP_001244950.1
• Gene: GRIA1 / 2890
• HGNCID: 4571
• Length: 916
• Species: Homo sapiens
• Sequence 2: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Alignment Length: 977
• Identity: 269/977 - (27%)
• Similarity: 433/977 - (44%)
• Gaps: 156/977 - (15%)

Human    21 WSNLL---CFLTPVKLHPEVWGLF----PNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSF 78
            |..:|   |          :|..|    ...|.....|| |...:|....:.:..::.:|..:|
  Fly     2 WQRILLLGC----------MWSAFFMCRSRGQQINIGAF-FYDDELELEKEFMTVVNAINGPES- 54

Human    79 EMTYRF--------------------CSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSF 123
            |.|.||                    |.....||.||||...:...:::...|.:..:    |..
  Fly    55 EQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGI----PHI 115

Human   124 PVDTS----------NQFVLQLRPE---LQDALISIIDHYKWQKFVYIYDAD--RGLSVLQKVLD 173
            ..|.|          :|..|.|.|.   |..|...|:.::.|:||..:||||  |..:.||.:|.
  Fly   116 EFDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQ 180

Human   174 TAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHY 238
            .....| .|..|... ..::.:|::::.:  :.||.||:|||...|..:|....:....|...|.
  Fly   181 LREVHN-DVVRVRKF-HKDDDFRVMWKSI--RGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHI 241

Human   239 ILANLGFMDIDLNKF----KESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYT 299
            .|.||......|.:.    :....|:|..:|:...|..|..:...:...  ||:...:...|..|
  Fly   242 FLTNLETYTDHLEELAADNETFAVNITAARLLVNPDPPPYSLPYGYVTQ--RDNIVYESSDPPRT 304

Human   300 --SALTYDGVKVMAEAFQS---LRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQ------Q 353
              ..|.:|.:::.|:::::   ....|:.:.|  ...|..|:....|..|..:.|.::      .
  Fly   305 LIHDLIHDALQLFAQSWRNASFFYPDRMVVPR--ITCDFAASGGRTWAMGRYLARLMKGTSGVNN 367

Human   354 VRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRT 418
            ..|.  |..:||:|.|:|..:.:.|.: ..||| .|..|:      |.....|...|..:.:...
  Fly   368 TNFR--TSILQFDEDGQRITFNIEVYD-PLDGI-GIAIWD------PRGQITQLNVDVKAQKKMI 422

Human   419 YIVTTILEDPYVMLKKNANQFE--GNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDT 481
            |.|.|.:..||....:.|.:..  ||..|:||.|:|...||:|||:.|....|:|.:||..|.:|
  Fly   423 YRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKET 487

Human   482 KAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLA 546
            |.|||::||::...|.:.:..||||..|:..:||:.|||.||:||:..|....:..:.::|.|..
  Fly   488 KQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFG 552

Human   547 YEIWMCIVFAYIGVSVVLFL---VSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAF 608
            .|:|:.|:   |.|.|:.||   |:|.|..:|.:.. ...||....:  |::.|.|:.|.::.:.
  Fly   553 GEVWIWIL---ISVFVMTFLKTIVARISKMDWENPH-PCNRDPEVLE--NQWRIHNTGWLTVASI 611

Human   609 MQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGT 673
            |..||||.|||...|:....||.|.:||.:|||||||||||..:|...|.:.:||:.|.::.:||
  Fly   612 MTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGT 676

Human   674 LEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQ 738
            :..|||......|...|:...:..|.:.:||.:.:...||:.||||::|.|.:|:|:|..|| .:
  Fly   677 IYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEY-HR 740

Human   739 RKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYD-KGECGSGGG 802
            .:.||...||.....|.|.||.|.|:..|:.:::|:|||:|:|.|..||.|||.: ...|..  .
  Fly   741 EQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFE--E 803

Human   803 DSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEF-------------CYKSRSESKRMKGFCL 854
            ...|.|..::...:.|:||.|..|:.:|.|:.:.||             .:|...:.:.....|:
  Fly   804 PDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCV 868

Human   855 ------------------IPQQSINEAI-------RTSTLPRNS--------GAGASSG----GS 882
                              .|::|:::::       |...:.|:|        |:|:|||    |.
  Fly   869 WNNRKPIVAGTPISSVRTTPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGSSSGSNNAGR 933

Human   883 GE 884
            ||
  Fly   934 GE 935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..402	CDD:380613	94/419 (22%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	143/386 (37%)
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	91/406 (22%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	142/377 (38%)
		Lig_chan	554..827	CDD:459656	101/281 (36%)