DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIA1 and Ir8a

DIOPT Version :9

Sequence 1:	NP_001244950.1	Gene:	GRIA1 / 2890	HGNCID:	4571	Length:	916	Species:	Homo sapiens
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	908	Identity:	218/908 - (24%)
Similarity:	367/908 - (40%)	Gaps:	211/908 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   152 WQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNI-LTTTEEGYRMLFQDLEKKKERLVVVDCE 215
            |.:.|...:.|..::::.|.|| |...:.:|....: ||.:|:|.     |:::..|.|..|...
  Fly    25 WIEPVQRAEFDTDIAMVLKELD-ALRLDVKVDDTTLTLTRSEDGL-----DMQRFCEILSTVGAS 83

Human   216 S----------ERLNAILGQIIKLEKNGIGYHYILANL-GFMDIDLNKFKESGANVTGFQLVNYT 269
            :          |..|.:       ...||||..:...: .|:|:..:..::..||......:|..
  Fly    84 AVIDLTYSHWEEGYNLV-------RSLGIGYVRLERIMRPFLDMFGDFMRQKRANNVAMVFMNAR 141

Human   270 DTIPAKIMQQW-------------KNSDARDH--TRVDWKRPK------YTSALTYDGV--KVM- 310
            |.:.|  |||.             ..:|...|  .|:...||.      :..|...:|:  ||.
  Fly   142 DAVEA--MQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQK 204

Human   311 AEAFQ-----------------SLRRQ-----RIDISRRGNAGDCLANPAVPWGQGIDIQRALQQ 353
            |:.||                 ..|||     |..::.|..... :..|.:..|.|..:|||:..
  Fly   205 ADLFQRPLEWHFVFLDTRDRVFKYRRQAELCTRFTLNPRAICRS-MPMPDLYCGSGFTMQRAMLL 268

Human   354 VRFEGLTGNVQFNEKGRRTNYTLHVIE---------MKHDGIRKIGY-------WNE-------- 394
            .....|....|.:     ..|.|.:.:         ...|.:.|..|       |:.
  Fly   269 NVLRSLINAAQVS-----PGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPL 328

Human   395 ---DDKF---VPAATDA---QAG------------------------GDNSSVQNRTYIVTTILE 426
               .|:|   ||..|.|   .||                        .:..|...|.:.:.|...
  Fly   329 PHIQDQFQSPVPGLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLNETISPARRFFRIGTAES 393

Human   427 DPYVMLKKNANQFE------GNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWN 485
            .|:..|::.....|      |...:||||::....:::.:.:.:.:.....|..|..: :...|:
  Fly   394 IPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELN-ELGEWD 457

Human   486 GMVGELVYGRADVAVAPLTITLVREEVIDFSKPFM-SLGISIMIKKPQKSKPGVFSFLDPLAYEI 549
            |:||:||.|..|.|:|.|.:...|||||||..|:. ..||||.|:||.: :..:|.|:..|..|:
  Fly   458 GVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEV 521

Human   550 WMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCD 614
            |:.||.|.:|.:::::.:.::|||.      .....|.......||.:..|.||:|.:|..||..
  Fly   522 WLSIVAALVGTAIMIWFMDKYSPYS------SRNNRQAYPYACREFTLRESFWFALTSFTPQGGG 580

Human   615 ISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGST 679
            .:|:::|||::...:|.|.:::::::|||||||||||||.:|::|.|.||:|:.|.|..::...|
  Fly   581 EAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDT 645

Human   680 KEFFRRSKIAV-----------------FEK--MWTY------------MKSAEPSVFVRTTEEG 713
            .::|...|.|.                 |:|  :|.|            :.|::|   |...:||
  Fly   646 HQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEG 707

Human   714 MIRV-RKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKL 777
            ...| ......||::.:|...:| |..:.|:..:||.....:.|.:|..:||.|.:.::.|:|:|
  Fly   708 FANVDAHENADYAFIHDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILEL 771

Human   778 NEQGLLDKLKNKWWYDKG--ECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCY 840
            .:....::||.|:|....  .|..    |:|: ..::|.::.|||...:.||.|||:...:|..|
  Fly   772 QKDRFFEELKAKYWNQSNLPNCPL----SEDQ-EGITLESLGGVFIATLFGLVLAMMTLGMEVLY 831

Human   841 KSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASSGGSGENGRVVSHDFPKSMQSIPCM 903
            ..:.:               |....|...|.|..:|  |||:.......:....|....||.:
  Fly   832 YKKKQ---------------NALEITQVRPVNDSSG--SGGNSSTAPPTATSTTKQAWHIPVL 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..399	CDD:107385	65/334 (19%)
		ANF_receptor	47..382	CDD:279440	59/296 (20%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	121/421 (29%)
		Lig_chan	548..827	CDD:278489	87/312 (28%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	120/414 (29%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	87/312 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910