Protein Alignment GRB10 and pico

DIOPT Version :9

• Sequence 1: XP_016867518.1
• Gene: GRB10 / 2887
• HGNCID: 4564
• Length: 710
• Species: Homo sapiens
• Sequence 2: NP_608363.1
• Gene: pico / 33003
• FlyBaseID: FBgn0261811
• Length: 1162
• Species: Drosophila melanogaster
• Alignment Length: 622
• Identity: 152/622 - (24%)
• Similarity: 236/622 - (37%)
• Gaps: 137/622 - (22%)

Human    21 AGGAHAATPCGQCCRPLS---------RLDRKHGSIYSASEASSGNLQSSFGADHNAEQEAAAAG 76
            :.||..|.|.|....|.|         ...|.|....|...|...:..||..:::.........|
  Fly   169 SAGAQIAPPPGVTQLPGSAPTMVSMSASSSRSHSRTNSTISADVSSCSSSGISENGHGLGLVLGG 233

Human    77 PVTGSSVTSSPVTGSQVLTWVLSVKPGWPPQQTVLQSQLLTEDDVDLEALVNDMNASLESLYSAC 141
            |.:...:...|..|...:...|.|               :|..:...|:..||
  Fly   234 PGSAGMMVQPPPPGGMTMGITLGV---------------VTPREPRTESPDND------------ 271

Human   142 SMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSL 206
            |..||||.||.:...|.|             ..|.:|:.|:.|..|....:..|.:.||.:
  Fly   272 SAFSDTVSLLSSESSASS-------------NTSLQQQQQQQQQQHHQHQQHHQHQQQQQK---- 319

Human   207 PAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQNRKSRAGDSSHHSLVLCHG---TCPLSTTAAG 268
                   |:|.|                          |....||.:...||   :...|.|.|.
  Fly   320 -------PQLAG--------------------------AEKLHHHGVHGQHGGQQSGANSITKAD 351

Human   269 ETRVGL-----VTQKQLFHIRDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLV 328
            :.::.|     ...::||    ||.|:.||.||.:.:...|....:.:||..|:|....::|.||
  Fly   352 KIQLALHKLESAPIRRLF----VKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWALV 412

Human   329 EHHPHLGLERCLEDHELVVQVESTMASE--SKFLFRKNYAKYEFFKNPMNFFP-EQMVTWCQQSN 390
            ||...|.:||..|||||:|....|..|:  ::.||::...|...|..|..:.| .||...||...
  Fly   413 EHLGDLQMERLFEDHELLVDNLMTWHSDAGNRVLFQQRPDKVTLFLRPELYLPGPQMAPGCQHDE 477

Human   391 GSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADL 455
            .::..||..|.:|.:..::.|.|::|...||.||:.:..||.||||...|..:|..|.|..|...
  Fly   478 QTRQMLLDEFFDSHNQLQMDGPLYMKADPKKGWKRYHFVLRSSGLYYFPKEKTKNTRDLACLNLF 542

Human   456 EDSNIFSLIAGRKQYNAPTDHGLCIK---PNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGM 517
            ...|:::.:..||::.:|||:....|   .:.:....:.|::|||||..|...|:||.|:.|||.
  Fly   543 HGHNVYTGLGWRKKWKSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGK 607

Human   518 LLYQNYRIPQQRKALLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRS 582
            .|:.::                 :|:.|:..::.|                .|..:...|...||
  Fly   608 QLWDSH-----------------KSLLEDLCLSRD----------------DAVSQSSFAASMRS 639

Human   583 TRMNILGSQSPLHPSTLSTVIHRTQHWFHGRISREES 619
            ..::.:.|..|....::|:.|....:...||.||..|
  Fly   640 ESISSISSAVPSQCGSVSSAISSMSNSTSGRTSRASS 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRB10	XP_016867518.1	None
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382	32/90 (36%)
		PH_APBB1IP	489..614	CDD:269961	41/141 (29%)
		PH	494..605	CDD:278594	36/110 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157315
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840