DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cct8 and CCT8

DIOPT Version :9

Sequence 1:	NP_001099367.2	Gene:	Cct8 / 288305	RGDID:	1305452	Length:	548	Species:	Rattus norvegicus
Sequence 2:	NP_610418.1	Gene:	CCT8 / 35882	FlyBaseID:	FBgn0284436	Length:	546	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	333/535 - (62%)
Similarity:	424/535 - (79%)	Gaps:	1/535 - (0%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MALHVPKAPGFAQMLKDGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINRLEKLFV 65
            |||.||||||.:|||||||:.:|||||||:|||.||||.|||.|:||||||||||:||.:||.||
  Fly     1 MALSVPKAPGVSQMLKDGARMYSGLEEAVFRNISACKEFAQTMRSAYGPNGMNKMIINHIEKQFV 65

  Rat    66 TNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIT 130
            |:||.||:|||:|:|||||:|||||.||:.|||||||||:|.||||||.||||||:|::.:|:..
  Fly    66 TSDAGTIMRELDVEHPAAKLIVMASQMQDAEVGDGTNFVVVLAGALLESAEELLRLGITTAEISD 130

  Rat   131 GYEIACKKAHEILPDLVCCSAKNLRDVDEVSSLLRTSIMSKQYGSEEFLAKLISQACVSIFPDSG 195
            |||.|.:||.||||:||....::.|:|::|..:|||||||||||.|:||..|:|:|||||.||.|
  Fly   131 GYEKALEKALEILPNLVSHKIEDYRNVEKVKEVLRTSIMSKQYGQEDFLNDLVSKACVSILPDEG 195

  Rat   196 NFNVDNIRVCKILGSGVYSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIK 260
            .|||||||:|||||||:..|.|:.|||||:..|||||..:.|||.::|||.|.:.||||||||||
  Fly   196 TFNVDNIRICKILGSGLTKSEVVRGMVFKRFVEGDVTYAEKAKIVIFSCPVDIIQTETKGTVLIK 260

  Rat   261 TAEELMNFSKGEENLMDAQVKAIAGTGANVIVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLC 325
            :|:||::||.|||:|:::|:||||..|..|:|.||||.|||||:.|||.:|.||||||:|||||.
  Fly   261 SADELLSFSSGEESLLESQIKAIADAGVKVVVAGGKVGDMALHFLNKYGLMAVRLNSKFDLRRLS 325

  Rat   326 KTVGATALPKLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIER 390
            ::|.||.||::|.|..||:|:||.|.:.|:|||.:|.|::|.:|..|:|:|:||:|||.||||||
  Fly   326 RSVNATVLPRITTPSQEELGYCDKVCIEELGDTTIVAFRNEGKDSRIATVVIRGATDNFMDDIER 390

  Rat   391 AVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAEN 455
            |:||.:|.||.||||.|.:||.||||||||.|:::|.:|.|||:|||::|||.|.|..|:|||||
  Fly   391 ALDDAINNFKCLTRDGRYLPGAGATEIELATQLSAYADTLPGLDQYAVRKFANALEVFPKALAEN 455

  Rat   456 SGVKANEVISKLYSVH-QEGNKNVGLDIEAEVPAVKDMLEASILDTYLGKYWAIKLATNAAVTVL 519
            ||:...|::::||..| .|..|.:|.|||||..:..|..:|.:.|.|..|:|.:|.|..||.|:|
  Fly   456 SGINGTEIVNQLYLAHNNEAGKTIGFDIEAEKASTIDTTKAKLFDLYQSKFWGLKYAVGAAATIL 520

  Rat   520 RVDQIIMAKPAGGPK 534
            :||||||||.|||||
  Fly   521 KVDQIIMAKRAGGPK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cct8	NP_001099367.2	chap_CCT_theta	10..539	CDD:274087	325/526 (62%)
Cct8	NP_001099367.2	Cpn60_TCP1	39..528	CDD:278544	296/489 (61%)
CCT8	NP_610418.1	TCP1_theta	20..529	CDD:239457	310/508 (61%)
CCT8	NP_610418.1	Cpn60_TCP1	40..529	CDD:278544	296/488 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337342
Domainoid	1	1.000	614	1.000	Domainoid score	I178
eggNOG	1	0.900	-	-		E1_KOG0362
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4802
Inparanoid	1	1.050	685	1.000	Inparanoid score	I681
OMA	1	1.010	-	-		QHG53640
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	1	1.000	-	-		FOG0004632
OrthoInspector	1	1.000	-	-		oto97510
orthoMCL	1	0.900	-	-		OOG6_102087
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3246
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770