DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANK3 and YAR1

DIOPT Version :9

Sequence 1:	NP_066267.2	Gene:	ANK3 / 288	HGNCID:	494	Length:	4377	Species:	Homo sapiens
Sequence 2:	NP_015085.1	Gene:	YAR1 / 855837	SGDID:	S000006160	Length:	200	Species:	Saccharomyces cerevisiae

Alignment Length:	128	Identity:	40/128 - (31%)
Similarity:	63/128 - (49%)	Gaps:	16/128 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    49 ARAGHLEKALDYIKNGVD---INIC--NQNGLNALHLASKEGHVEVVSELLQR----------EA 98
            ||||.|:...|.....|.   ::.|  :::...|||:|:..||:|.|..:|:.          :|
Yeast    20 ARAGDLDSLKDIFTTLVSPELLSTCKESESDSTALHMAAANGHIETVRYILETVSRANSAEDLKA 84

Human    99 NVDAATKKGNTALHIASLAGQAEVVKVLVTN-GANVNAQSQNGFTPLYMAAQENHLEVVKFLL 160
            .|:...|.||||||.|||.|:.:|||:|... .|:...:::.|...::.|......||..:.|
Yeast    85 FVNEVNKTGNTALHWASLNGKLDVVKLLCDEYEADPFIRNKFGHDAIFEAENSGKEEVETYFL 147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANK3	NP_066267.2	ANK 6	234..263
		ANK repeat	267..298	CDD:293786
		ANK 7	267..296
		Ank_2	272..363	CDD:289560
		ANK	295..420	CDD:238125
		ANK 8	300..329
		ANK repeat	300..325	CDD:293786
		ANK repeat	333..364	CDD:293786
		ANK 9	333..362
		ANK	361..486	CDD:238125
		ANK 10	366..395
		ANK repeat	369..397	CDD:293786
		Ank_2	371..463	CDD:289560
		ANK repeat	399..430	CDD:293786
		ANK 11	399..428
		ANK repeat	432..463	CDD:293786
		ANK 12	432..461
		ANK	460..585	CDD:238125
		ANK repeat	465..496	CDD:293786
		ANK 13	465..494
		Ank_2	470..561	CDD:289560
		ANK repeat	498..529	CDD:293786
		ANK 14	498..527
		ANK repeat	531..560	CDD:293786
		ANK 15	531..560
		Ank_2	536..626	CDD:289560
		ANK	560..684	CDD:238125
		ANK repeat	564..593	CDD:293786
		ANK 16	564..593
		ANK repeat	597..626	CDD:293786
		ANK 17	597..626
		ANK repeat	630..660	CDD:293786
		ANK 18	630..659
		Ank_4	631..684	CDD:290365
		ANK	658..783	CDD:238125
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Ank_4	47..94	CDD:290365	16/49 (33%)
		ANK	68..193	CDD:238125	33/106 (31%)
		ANK repeat	73..104	CDD:293786	11/40 (28%)
		ANK 1	73..102		11/38 (29%)
		Ank_2	78..164	CDD:289560	31/94 (33%)
		ANK repeat	106..137	CDD:293786	15/31 (48%)
		ANK 2	106..135		15/29 (52%)
		ANK 3	139..168		5/22 (23%)
		ANK repeat	139..164	CDD:293786	5/22 (23%)
		Ank_4	140..193	CDD:290365	5/21 (24%)
		ANK 4	172..201
		ANK 5	203..230
		ANK repeat	205..232	CDD:293786
		Ank_2	206..297	CDD:289560
		ANK	229..354	CDD:238125
		ANK repeat	234..265	CDD:293786
		ANK repeat	663..694	CDD:293786
		ANK 19	663..692
		Ank_2	669..759	CDD:289560
		ANK repeat	696..727	CDD:293786
		ANK 20	696..725
		ANK repeat	729..760	CDD:293786
		ANK 21	729..758
		Ank_5	749..803	CDD:290568
		ANK 22	762..791
		ANK repeat	762..790	CDD:293786
		ANK 23	795..825
		ZU5	982..1086	CDD:128514
UPA domain. /evidence=ECO:0000250	1273..1407
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1519..1540
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1968..1987
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2107..2159
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2176..2245
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2299..2322
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2383..2433
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2474..2508
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2588..2751
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2795..2824
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3036..3067
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3131..3272
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3298..3516
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3538..3607
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3635..3718
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3868..3897
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4019..4090
Death_ank3	4088..4171	CDD:176781
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4251..4298
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4323..4377
YAR1	NP_015085.1	ANK repeat	11..47	CDD:293786	8/26 (31%)
		Ank_2	20..124	CDD:403870	35/103 (34%)
		ANK repeat	49..90	CDD:293786	11/40 (28%)
		ANK repeat	92..124	CDD:293786	15/31 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2336
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030