DRSC/TRiP Functional Genomics Resources

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Protein Alignment ANK3 and SET3

DIOPT Version :10

Sequence 1:NP_066267.2 Gene:ANK3 / 288 HGNCID:494 Length:4377 Species:Homo sapiens
Sequence 2:NP_012954.3 Gene:SET3 / 853900 SGDID:S000001737 Length:751 Species:Saccharomyces cerevisiae


Alignment Length:972 Identity:183/972 - (18%)
Similarity:308/972 - (31%) Gaps:366/972 - (37%)


- Green bases have known domain annotations that are detailed below.


Human  3459 FSQSKLEVIEEEGKVGPDEDKPPSKSSSSEKTPDKTDQKSGAQFFTLEGRHPDRSVFPDTYFSYK 3523
            ||:.|... ||..|:|       ||:.:.|.......:|.||                       
Yeast    21 FSKGKKRA-EEASKIG-------SKTDTIEHDESHEREKKGA----------------------- 54

Human  3524 VDEEFATPFKTVATKGLDFDPWSNNRGDDEVFDSKSREDETKPFGLAVEDRSPATTPDTTPARTP 3588
             .|..|....|.:|..|                         |...|.| :|.|....:|.|:..
Yeast    55 -IEMAAAALATASTVSL-------------------------PLKKATE-QSAAEAATSTAAKEE 92

Human  3589 TDESTPTSEPNPFPFHEGKMFEMTRSGAI----DMSKRDFVEERLQFFQIGEHTSEGKSGDQGEG 3649
            | |:.|..:|. :|..:..:.: ..:|.|    |::..|....:.......:|.......|.|..
Yeast    93 T-ENQPQKQPQ-WPVPDSYIVD-PDAGIITCICDLNDDDGFTIQCDHCNRWQHAICYGIKDIGMA 154

Human  3650 DKSMVTATPQPQSGDTTVETNLERNVE-----TPTVEPNPSIPTSGECQEGTSSSGSLEKSAAAT 3709
            ....:..:..|:.    |:.||.|.::     ..||||:.|       ....|:..:....|::|
Yeast   155 PDDYLCNSCDPRE----VDINLARKIQQERINVKTVEPSSS-------NNSASNKNNGRDRASST 208

Human  3710 NTSKVDPKLRTPIKMGISAST--------MTMKKEGPGEITDKIEAVMTSCQGLENETITMISNT 3766
            ..|.|          |.|.||        ...:|..|.  .:.|::        :||:.::.|:.
Yeast   209 TISDV----------GDSFSTDQDNTNHRDKRRKRNPS--NNSIDS--------KNESASVNSSD 253

Human  3767 ANSQMGVRPHEKHDF-------------QKDN---------FNNNNNLDSSTIQTDNIMSNIVLT 3809
            ..:.|   |.:|..|             .|||         |.|.:..|:..||..:.....|..
Yeast   254 GLTSM---PKKKEHFLSAKDAYGAIYLPLKDNVFKSDLIEPFLNKHMDDNWVIQYPHKTFKSVSI 315

Human  3810 E----------HSAPTCTTEKDNPVKVSSGKKTGV-LQGHCVRDK--QKVLGEQQKTKELIGIRQ 3861
            |          .:.|..|             |.|| |:..|::..  |::|||....|..:    
Yeast   316 EVKPYADIAYSRTYPGFT-------------KLGVYLKKDCIKGDFIQEILGELDFYKNYL---- 363

Human  3862 KSKLPIKATSPKDTFPPNHMSNTKASKMKQVSQSEKTKALTTSSCVDVKSRIPVKNTHRDNIIAV 3926
                         |.|.||......:|.:.:..|...        :.:.:|:...:|.     .:
Yeast   364 -------------TDPRNHYRIWGTAKRRVIFHSHWP--------IYIDARLSGNSTR-----YL 402

Human  3927 RKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVTTTTTTATTTTTTTTTTTTSCTVKVRKSQLKE 3991
            |::|      ||                 :..:.|.....|......::...|..:|.....|::
Yeast   403 RRSC------QP-----------------NVELVTIKLQDTDNRNDKSSGRKSSRIKFVLRALRD 444

Human  3992 V-------------CKHSIEYFKGISGETLKLVDRLSEEEK-----KMQSELSDEE---ESTSRN 4035
            :             .||.|  .|.|.|.|   :|.|.:.|:     .:::.||:.|   .:.|::
Yeast   445 ISEDEELYIKWQWDSKHPI--LKLIKGMT---IDSLDDLERYGLINSVETILSNGECGCGNNSKD 504

Human  4036 TSLSETSRGGQPSVTTKSAR------------------DKKTEAAPLKSKSEKAGS--------- 4073
            ..|.:..|..|....:..:|                  .|:.|...|....|||.:         
Yeast   505 CYLLKVKRYAQSLYKSVKSRGKMNNRYKLNEILNQYNCKKRREPPILHRLEEKAQNTIERAPILL 569

Human  4074 -----EKRSSRRTGPQSPCERT--------DI----RMAIVADHLGLSWTELARELNFSVDEINQ 4121
                 :|..:|..||:.|.:.|        ||    :.|:.|.|          ..|.||.:.|:
Yeast   570 NNFYRQKFLNRNNGPKIPQKNTIDSTNNPDDIAKPFKFALFAQH----------SSNISVPKKNE 624

Human  4122 IRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSF 4186
                     .|:..:::.|         :||...|.:|.|..:.|..||                
Yeast   625 ---------TSEKPLIITK---------STDYDESHITNIEELPIPVLL---------------- 655

Human  4187 ADENNVFHDPVDGWQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEAN 4251
                     |::....:|::...||.::...       :|..:|     |::::.| |..| ||.
Yeast   656 ---------PINKTSRQTANDVEESQSKNEH-------KLSRTP-----SLSNFNK-ELSK-EAQ 697

Human  4252 GSHTEITPEAKTKSYFPESQNDVGKQSTKETLKPKIHGSG------HVEEPASPLAAYQKSL 4307
            .|      :||||....|:..:..::||.|::   :|.|.      |.::..| .|.|:|.|
Yeast   698 HS------QAKTKEIMTEASVNSRRESTPESI---MHLSDFSSSQLHSKKKLS-FADYRKKL 749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANK3NP_066267.2 ANKYR 1..305 CDD:440430
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44
ANK repeat 73..104 CDD:293786
ANK 1 73..102
ANK repeat 106..137 CDD:293786
ANK 2 106..135
ANK 3 139..168
ANK repeat 139..164 CDD:293786
ANK 4 172..201
ANK 5 203..230
ANK repeat 205..232 CDD:293786
ANK repeat 234..265 CDD:293786
ANK 6 234..263
ANKYR 248..536 CDD:440430
ANK repeat 267..298 CDD:293786
ANK 7 267..296
ANK 8 300..329
ANK repeat 300..325 CDD:293786
ANK repeat 333..364 CDD:293786
ANK 9 333..362
ANK 10 366..395
ANK repeat 369..397 CDD:293786
ANK repeat 399..430 CDD:293786
ANK 11 399..428
ANKYR 413..701 CDD:440430
ANK repeat 432..463 CDD:293786
ANK 12 432..461
ANK repeat 465..496 CDD:293786
ANK 13 465..494
ANK repeat 498..529 CDD:293786
ANK 14 498..527
ANK repeat 531..560 CDD:293786
ANK 15 531..560
ANK repeat 564..593 CDD:293786
ANK 16 564..593
ANK repeat 597..626 CDD:293786
ANK 17 597..626
PHA02875 605..>800 CDD:165206
ANK repeat 630..660 CDD:293786
ANK 18 630..659
ANK repeat 663..694 CDD:293786
ANK 19 663..692
ANK repeat 696..727 CDD:293786
ANK 20 696..725
ANK repeat 729..760 CDD:293786
ANK 21 729..758
ANK 22 762..791
ANK repeat 762..790 CDD:293786
ANK 23 795..825
ZU5 982..1086 CDD:128514
UPA domain. /evidence=ECO:0000250 1273..1407
UPA_2 1308..1437 CDD:375346
Herpes_BLLF1 <1393..1770 CDD:282904
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1519..1540
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..1987
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2107..2159
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2176..2245
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2299..2322
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2383..2433
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2474..2508
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2588..2751
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2795..2824
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3036..3067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3131..3272
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3298..3516 13/56 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3538..3607 13/68 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3635..3718 18/87 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3868..3897 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4019..4090 19/110 (17%)
Death_ank3 4088..4171 CDD:176781 19/94 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4251..4298 12/52 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4323..4377
SET3NP_012954.3 PHD_MLL5 119..163 CDD:277025 5/43 (12%)
SET_SpSET3-like 321..507 CDD:380960 43/256 (17%)
Blue background indicates that the domain is not in the aligned region.

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