DRSC/TRiP Functional Genomics Resources

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Protein Alignment ANK3 and DEF1

DIOPT Version :10

Sequence 1:NP_066267.2 Gene:ANK3 / 288 HGNCID:494 Length:4377 Species:Homo sapiens
Sequence 2:NP_012869.1 Gene:DEF1 / 853811 SGDID:S000001537 Length:738 Species:Saccharomyces cerevisiae


Alignment Length:858 Identity:148/858 - (17%)
Similarity:275/858 - (32%) Gaps:261/858 - (30%)


- Green bases have known domain annotations that are detailed below.


Human  2879 RENHIGH------PESKS--------------------VDQKNEFMSVTERERKLLTNGSLSEIK 2917
            :.||..|      |..||                    |.:.::..::.::    :|:|:::...
Yeast     7 KSNHNSHSSKKLNPALKSKIDTLTELFPDWTSDDLIDIVQEYDDLETIIDK----ITSGAVTRWD 67

Human  2918 EMTVKSPSKKVLYREYVVKEGDHPGGLLDQPSRRSESSAV--SHIPVRVADERRMLSSNIPDGFC 2980
            |  ||.|:||   .:|..||..|              |.|  .|:| ...|:....|||..:.|.
Yeast    68 E--VKKPAKK---EKYEKKEQQH--------------SYVPQQHLP-NPEDDITYKSSNNSNSFT 112

Human  2981 EQSAFPKHELSQKLSQSSMSKETVET-------QHFNSIEDEKVTYSEISKVSKHQSYVGLCPPL 3038
            .    .||..|...:| :.:|:.|:|       :|.|..:.:.|....:|..:...:.|.:....
Yeast   113 S----TKHNSSNNYTQ-ARNKKKVQTPRAHTTGKHVNLDKGKHVPSKPVSNTTSWAAAVSVDTKH 172

Human  3039 EETETSPTKSPDSLEFSPGKESPSSDVFDHSPIDGLEKLAPLAQTEGGKEIKTLPVYVSFVQVGK 3103
            :..:.|...:.:.||                           ||.:..:|              |
Yeast   173 DVPQDSNDNNNEELE---------------------------AQGQQAQE--------------K 196

Human  3104 QYEKEIQQGGVKKIISQECKTVQETRGTFYTTRQQKQPPSPQGSPEDDTLEQVSFLDSSGKSPLT 3168
            ..|||                 ||         :|:|........|...:||.|.  ||.|:  |
Yeast   197 NQEKE-----------------QE---------EQQQQEGHNNKEEHKQIEQPSL--SSKKT--T 231

Human  3169 PETPSSEEVSYEFTS-KTPDSLIAYIPGKP-------SPIPEVSEESEEEEQAKSTSLKQTTVEE 3225
            ..|.:|:.....:.: .||         ||       ||:..|:|..:|....|....|....||
Yeast   232 SRTSASQPKKMSWAAIATP---------KPKAVKKTESPLENVAELKKEISDIKKDDQKSEASEE 287

Human  3226 TAVEREMPNDVSKDSNQRP---KNNRVAYIEFPPPPPLDADQI--ESDKKHHYLPEKEVDMIEVN 3285
            ...|:|......::....|   ..:||        |.:|.:::  |::||...   ||.:.....
Yeast   288 KVNEQETSAQEQEEETAEPSEENEDRV--------PEVDGEEVQEEAEKKEQV---KEEEQTAEE 341

Human  3286 LQDEHDKYQLAEPVIRVQPPSPVPPGADVSDSSDDESIYQPVPVKKYTFKLKEVDDEQKEKPKAS 3350
            |:.|.|.....|..:.| ....|...|.:|:..:|::...|.|.::.....:....:|.::|:..
Yeast   342 LEQEQDNVAAPEEEVTV-VEEKVEISAVISEPPEDQANTVPQPQQQSQQPQQPQQPQQPQQPQQP 405

Human  3351 AEKASNQKELESNGSGKDNEFGLGLDSPQNEIAQNGNNDQSITECSIATTAEFSHDTDATEIDSL 3415
            .::...|:.                ..||.::.|.....|...:.          ...|.|....
Yeast   406 QQQQQPQQP----------------QQPQQQLQQQQQQQQQPVQA----------QAQAQEEQLS 444

Human  3416 DGYDLQDEDDGLTESDSKLPIQAMEIKKDIWNTEGILKPADRSFSQSKLEVIEEEGKVGPDEDKP 3480
            ..|..|.:.....:...:|..|.:.              ..:.::|.:.:           ..:|
Yeast   445 QNYYTQQQQQQYAQQQHQLQQQYLS--------------QQQQYAQQQQQ-----------HPQP 484

Human  3481 PSKSSSSEKTPDKTDQKSG-----AQFFTLEGRHPDRSVFPDTYFS--YKVDEEFATPFKTVATK 3538
            .|:...|:::|.  .||.|     .|::..:.:.|..| :|..:.|  |...:::....:..|..
Yeast   485 QSQQPQSQQSPQ--SQKQGNNVAAQQYYMYQNQFPGYS-YPGMFDSQGYAYGQQYQQLAQNNAQT 546

Human  3539 GLDFDPWSNNRGDDEVFDSKSREDETKPFGLAVEDRSPATTPDTTPARTP------------TDE 3591
            ..:.:.::..:|..:...:.:..:.|.  ..|....||||.......:.|            ..:
Yeast   547 SGNANQYNFQQGYGQAGANTAAANLTS--AAAAAAASPATAHAQPQQQQPYGGSFMPYYAHFYQQ 609

Human  3592 STPTSEP-----NPFPFHEGK---MFEMTRSGAIDMSKRDFVEERLQFFQIGEHTSEGKSGDQGE 3648
            |.|..:|     ..:|:...|   .:..|::|....|...         .:.:|:.:.:.....:
Yeast   610 SFPYGQPQYGVAGQYPYQLPKNNYNYYQTQNGQEQQSPNQ---------GVAQHSEDSQQKQSQQ 665

Human  3649 GDKSMVTATPQPQ 3661
            ..:......|||:
Yeast   666 QQQQQPQGQPQPE 678

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANK3NP_066267.2 ANKYR 1..305 CDD:440430
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44
ANK repeat 73..104 CDD:293786
ANK 1 73..102
ANK repeat 106..137 CDD:293786
ANK 2 106..135
ANK 3 139..168
ANK repeat 139..164 CDD:293786
ANK 4 172..201
ANK 5 203..230
ANK repeat 205..232 CDD:293786
ANK repeat 234..265 CDD:293786
ANK 6 234..263
ANKYR 248..536 CDD:440430
ANK repeat 267..298 CDD:293786
ANK 7 267..296
ANK 8 300..329
ANK repeat 300..325 CDD:293786
ANK repeat 333..364 CDD:293786
ANK 9 333..362
ANK 10 366..395
ANK repeat 369..397 CDD:293786
ANK repeat 399..430 CDD:293786
ANK 11 399..428
ANKYR 413..701 CDD:440430
ANK repeat 432..463 CDD:293786
ANK 12 432..461
ANK repeat 465..496 CDD:293786
ANK 13 465..494
ANK repeat 498..529 CDD:293786
ANK 14 498..527
ANK repeat 531..560 CDD:293786
ANK 15 531..560
ANK repeat 564..593 CDD:293786
ANK 16 564..593
ANK repeat 597..626 CDD:293786
ANK 17 597..626
PHA02875 605..>800 CDD:165206
ANK repeat 630..660 CDD:293786
ANK 18 630..659
ANK repeat 663..694 CDD:293786
ANK 19 663..692
ANK repeat 696..727 CDD:293786
ANK 20 696..725
ANK repeat 729..760 CDD:293786
ANK 21 729..758
ANK 22 762..791
ANK repeat 762..790 CDD:293786
ANK 23 795..825
ZU5 982..1086 CDD:128514
UPA domain. /evidence=ECO:0000250 1273..1407
UPA_2 1308..1437 CDD:375346
Herpes_BLLF1 <1393..1770 CDD:282904
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1519..1540
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..1987
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2107..2159
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2176..2245
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2299..2322
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2383..2433
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2474..2508
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2588..2751
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2795..2824
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3036..3067 3/30 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3131..3272 35/153 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3298..3516 31/222 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3538..3607 12/85 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3635..3718 4/27 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3868..3897
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4019..4090
Death_ank3 4088..4171 CDD:176781
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4251..4298
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4323..4377
DEF1NP_012869.1 CUE_DEF1_like 23..61 CDD:270551 4/41 (10%)
Blue background indicates that the domain is not in the aligned region.

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