DRSC/TRiP Functional Genomics Resources

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Protein Alignment ANK3 and SET4

DIOPT Version :10

Sequence 1:NP_066267.2 Gene:ANK3 / 288 HGNCID:494 Length:4377 Species:Homo sapiens
Sequence 2:NP_012430.1 Gene:SET4 / 853339 SGDID:S000003641 Length:560 Species:Saccharomyces cerevisiae


Alignment Length:556 Identity:108/556 - (19%)
Similarity:191/556 - (34%) Gaps:169/556 - (30%)


- Green bases have known domain annotations that are detailed below.


Human  1738 TATLQEKISSATNSVSSVVSAATD-------TVEKVFSTTTAMP-FSPLRSYVSAAPSA------ 1788
            |.|..:|:.|.::|.||..|.:.|       :|....|.|...| :.|:|:: :..|:|      
Yeast    17 TYTTTDKVISRSSSYSSNSSMSKDYGDHTPLSVSSAASETLPSPQYMPIRTF-NTMPTAGPTPLH 80

Human  1789 -FQSLRTPSASALYTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPALKKLPDSNSFTKSAAAL 1852
             ||:.|  .....::|.|||.:|:|:.  ..|......:....:|.|..|:..|.||........
Yeast    81 LFQNDR--GIFNHHSSSGSSKTASTNK--RGIAAAVALATAATIPFPLKKQNQDDNSKVSVTHNE 141

Human  1853 LSPIKTLTTETHPQPHFSRT-----SSPVKSSLFLAPS-----------ALKLSTPSSLSSSQEI 1901
            .|....:|.....:.:..:.     ||..|..||:..:           |.|.|.|         
Yeast   142 SSKENKITPSMRAEDNKPKNGCICGSSDSKDELFIQCNKCKTWQHKLCYAFKKSDP--------- 197

Human  1902 LKDVAEMKEDLM--RMTAILQTDVPEEKPFQPELPKEGRIDDEEPFKIVEKVKEDLVKVSEILKK 1964
                  :|.|.:  |..:..:..|.:.||.  ..|:  ::.||..|:.           |.|:..
Yeast   198 ------IKRDFVCKRCDSDTKVQVNQVKPM--IFPR--KMGDERLFQF-----------SSIVTT 241

Human  1965 DVCVDNKGSPKSPKSDKGHSPEDDWIEFSSEEIREARQQAAASQSPSLPERVQVKAKAASEKDYN 2029
            .....|:           |....:.||      .:.:::.....:|:......::.|...||...
Yeast   242 SASNTNQ-----------HQQSVNNIE------EQPKKRQLHYTAPTTENSNSIRKKLRQEKLVV 289

Human  2030 LTKVIDYLTNDIGSSSLTNLKYKFEDAKKDGEERQKRVLKPAIALQEHK---LKM---------- 2081
            .:..:..|.|::.||:.|..|                    ||.:.|:|   :||          
Yeast   290 SSHFLKPLLNEVSSSNDTEFK--------------------AITISEYKDKYVKMFIDNHYDDDW 334

Human  2082 -----------PPASMRTSTSEKELCKMADSFFGTDTILES---PDDFSQHDQDKSPLSDSGFET 2132
                       ....:|.|::|::.     ..|..|:.::.   .:...:.|..|:..:|...:.
Yeast   335 VVCSNWESSRSADIEVRKSSNERDF-----GVFAADSCVKGELIQEYLGKIDFQKNYQTDPNNDY 394

Human  2133 RSEKTPSAPQSAESTGPKPLFHEVPIPPVITETRTE---VVHVIRSYDPSAGDVPQTQPEEPVSP 2194
            |...|         |.||.|||  |..|:..::|..   ..::.||.:|:.         |.|:.
Yeast   395 RLMGT---------TKPKVLFH--PHWPLYIDSRETGGLTRYIRRSCEPNV---------ELVTV 439

Human  2195 KPSPTFMELEPKPTTSS---IKEKVKAFQMKASSEE 2227
            :|      |:.||...:   :|..::|.:.....||
Yeast   440 RP------LDEKPRGDNDCRVKFVLRAIRDIRKGEE 469

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANK3NP_066267.2 ANKYR 1..305 CDD:440430
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44
ANK repeat 73..104 CDD:293786
ANK 1 73..102
ANK repeat 106..137 CDD:293786
ANK 2 106..135
ANK 3 139..168
ANK repeat 139..164 CDD:293786
ANK 4 172..201
ANK 5 203..230
ANK repeat 205..232 CDD:293786
ANK repeat 234..265 CDD:293786
ANK 6 234..263
ANKYR 248..536 CDD:440430
ANK repeat 267..298 CDD:293786
ANK 7 267..296
ANK 8 300..329
ANK repeat 300..325 CDD:293786
ANK repeat 333..364 CDD:293786
ANK 9 333..362
ANK 10 366..395
ANK repeat 369..397 CDD:293786
ANK repeat 399..430 CDD:293786
ANK 11 399..428
ANKYR 413..701 CDD:440430
ANK repeat 432..463 CDD:293786
ANK 12 432..461
ANK repeat 465..496 CDD:293786
ANK 13 465..494
ANK repeat 498..529 CDD:293786
ANK 14 498..527
ANK repeat 531..560 CDD:293786
ANK 15 531..560
ANK repeat 564..593 CDD:293786
ANK 16 564..593
ANK repeat 597..626 CDD:293786
ANK 17 597..626
PHA02875 605..>800 CDD:165206
ANK repeat 630..660 CDD:293786
ANK 18 630..659
ANK repeat 663..694 CDD:293786
ANK 19 663..692
ANK repeat 696..727 CDD:293786
ANK 20 696..725
ANK repeat 729..760 CDD:293786
ANK 21 729..758
ANK 22 762..791
ANK repeat 762..790 CDD:293786
ANK 23 795..825
ZU5 982..1086 CDD:128514
UPA domain. /evidence=ECO:0000250 1273..1407
UPA_2 1308..1437 CDD:375346
Herpes_BLLF1 <1393..1770 CDD:282904 11/38 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1519..1540
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..1987 2/18 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2107..2159 12/54 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2176..2245 11/55 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2299..2322
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2383..2433
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2474..2508
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2588..2751
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2795..2824
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3036..3067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3131..3272
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3298..3516
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3538..3607
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3635..3718
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3868..3897
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4019..4090
Death_ank3 4088..4171 CDD:176781
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4251..4298
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4323..4377
SET4NP_012430.1 PHD_SF 163..207 CDD:473978 11/58 (19%)
SET_SpSET3-like 346..527 CDD:380960 32/155 (21%)
Blue background indicates that the domain is not in the aligned region.

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