DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANK3 and Ank

DIOPT Version :9

Sequence 1:	NP_066267.2	Gene:	ANK3 / 288	HGNCID:	494	Length:	4377	Species:	Homo sapiens
Sequence 2:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster

Alignment Length:	1460	Identity:	747/1460 - (51%)
Similarity:	995/1460 - (68%)	Gaps:	110/1460 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    37 KKSDANASYLRAARAGHLEKALDYIKNG--VDINICNQNGLNALHLASKEGHVEVVSELLQREAN 99
            |::||..|:|||||:|.::|.:|::..|  .|||.||.|||||||||:|:|:|::..|||:|...
  Fly    34 KQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDICCELLRRGIK 98

Human   100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164
            :|.|||||||||||||||||.:|:..|:...||||.||.||||||||||||||....:.||.|||
  Fly    99 IDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPLYMAAQENHDNCCRTLLANGA 163

Human   165 SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNAD 229
            :.||:|||||||||||:|||||::|::|||||.:||||||||||||:|:|..||.||||:|.|||
  Fly   164 NPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLLQHDPNAD 228

Human   230 VESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294
            :.||||||||||||||||:::||||||..|.|::.|:::|||||||.|.|..::..|||.|||||
  Fly   229 IVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKI 293

Human   295 DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVP 359
            ||.||||||||||.:||||.:|::.||.:.||||:|||||||.||||.||:|.....|||.:..|
  Fly   294 DAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAP 358

Human   360 VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGA 424
            ||:||.||||||||||||||.||||:|||.||||||:||||||||||||||||||::|||:||||
  Fly   359 VDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGA 423

Human   425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDG 489
            :|.|.|||||||:|||:|||.:|||..|:.|.||.:...:||||.||:|||:.||:::|.|:: .
  Fly   424 NIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRILLR-S 487

Human   490 AQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH 554
            |:|:|.|::.|||||:::|||..:|:..|||.||..||.:...|:.||::|:||.|::...||::
  Fly   488 AKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLEN 552

Human   555 GASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLD 619
            ||..:..|||||||||:|.||||..|..:|||..||.|..||:.:||||||.||:|..:..|||.
  Fly   553 GAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLK 617

Human   620 QGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 684
            .|:||:..|:||...:|||.|||.::||..||::|||.|.:::.|.:.:|||||.|:||||.|||
  Fly   618 NGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLL 682

Human   685 GRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749
            .... ::.:.|:||||||:||||..|.|:::|:..||::..:|:.||||||:..|||::.:|.|.
  Fly   683 EYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFF 746

Human   750 LQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDT 814
            :::.|.:...:..|||||||||||||..|||:||::.|:||.||.:|||||.||..|||::|:::
  Fly   747 IENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGYVTVMES 811

Human   815 LKIVTEETMTTT---TVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAM 876
            |||||..::..:   .:.||.|:..||.|.|.|               |||    ||.|..:|.:
  Fly   812 LKIVTSTSVINSNIGAIEEKLKVMTPELMQETL---------------LSD----SDDESCDDLL 857

Human   877 TGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYT----LNRSSYARDSMMI 937
            ..:..||:...|||.              :.|....:..:.::|...|    ||:.....:.|..
  Fly   858 DHNHYKYMATDDLKA--------------NYGQDQKNFDTTNTDHDLTDVSVLNKKEILPNEMSC 908

Human   938 EELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGSMRGSRH 1002
            .||                 ..:.|..      |||.:..|.:|.||||||:||||||||||.||
  Fly   909 IEL-----------------TEIGHKP------DNVVIARSQVHLGFLVSFLVDARGGSMRGYRH 950

Human  1003 HGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHF 1067
            :|:|||:||:.|..|||||||.||..::.||||::|||.|.||::||.|....||.|:.:|:||:
  Fly   951 NGVRIIVPPKACAEPTRITCRYVKPQRVVNPPPLMEGEALVSRILEMSPVDGMFLSPITLEVPHY 1015

Human  1068 GSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDFPQ 1132
            |::|..|||:|:|||:|||:|:||..   .:|:      :.|:::..||....||.||:|::.|.
  Fly  1016 GTLRKNEREIIILRSDNGESWREHNL---YKDI------IGEDINQTEEFHSDRIVRIVTQNVPH 1071

Human  1133 YFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGNKA 1197
            :||||||::||.:.|||:||.:.||.||.|:|.||..||||:||||||||.|......|:||...
  Fly  1072 FFAVVSRVRQEVHVIGPDGGTVFSTAVPQVKAIFPPHALTKKIRVGLQAQSVDLVECSKLLGQGV 1136

Human  1198 TFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGD---TTPNLRLLCSITGGTSPAQWED 1259
            ..||:||||||||||||.||::||.|......:.|...|:   ::|.|||||||:||.:.|.|||
  Fly  1137 AVSPVVTVEPRRRKFHKAITLSIPAPKACTNSMVNACYGNGNSSSPTLRLLCSISGGQTRATWED 1201

Human  1260 ITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPYMAKFVVFAKMNDPV 1324
            :||:|||:|::|.|:|||.|||||||.||..:::...:||:||..|..||:..|||:|||.....
  Fly  1202 VTGSTPLSFVRDSVTFTTTVSARFWLIDCRNIIDAGRMATELYSHLAKVPFYVKFVIFAKRISQT 1266

Human  1325 ESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYS 1389
            |:....|||||||.||||||||.|:|||:|:|||||:.:.:|::..||:.|:.|.|:||...|..
  Fly  1267 EAKFSVFCMTDDKEDKTLEQQEYFKEVAKSRDIEVLQNQIVYLEFAGNIVPILKKGEQLYTKFQP 1331

Human  1390 FKENRLPFSIKIRDTSQE-PCGRLSFLKEPKT-TKGLPQTAVCNLNIT----------------- 1435
            |.||||.||..|:|  || |.||:.|:..|.. ...:|...:|.|||:
  Fly  1332 FCENRLSFSAHIKD--QEFPHGRICFMTYPMVGPDEVPLKPLCTLNISVDFKTITNHLERDNLHS 1394

Human  1436 ----LPAHKKETESD------QDDEIEKTD 1455
                :.||.|...::      ::.:::|.|
  Fly  1395 LNDCINAHGKLNHNENIVFGVKEQQVKKID 1424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANK3	NP_066267.2	ANK 6	234..263		22/28 (79%)
		ANK repeat	267..298	CDD:293786	19/30 (63%)
		ANK 7	267..296		17/28 (61%)
		Ank_2	272..363	CDD:289560	57/90 (63%)
		ANK	295..420	CDD:238125	92/124 (74%)
		ANK 8	300..329		18/28 (64%)
		ANK repeat	300..325	CDD:293786	15/24 (63%)
		ANK repeat	333..364	CDD:293786	17/30 (57%)
		ANK 9	333..362		16/28 (57%)
		ANK	361..486	CDD:238125	89/124 (72%)
		ANK 10	366..395		25/28 (89%)
		ANK repeat	369..397	CDD:293786	24/27 (89%)
		Ank_2	371..463	CDD:289560	69/91 (76%)
		ANK repeat	399..430	CDD:293786	25/30 (83%)
		ANK 11	399..428		24/28 (86%)
		ANK repeat	432..463	CDD:293786	18/30 (60%)
		ANK 12	432..461		18/28 (64%)
		ANK	460..585	CDD:238125	59/124 (48%)
		ANK repeat	465..496	CDD:293786	16/30 (53%)
		ANK 13	465..494		15/28 (54%)
		Ank_2	470..561	CDD:289560	40/90 (44%)
		ANK repeat	498..529	CDD:293786	16/30 (53%)
		ANK 14	498..527		14/28 (50%)
		ANK repeat	531..560	CDD:293786	11/28 (39%)
		ANK 15	531..560		11/28 (39%)
		Ank_2	536..626	CDD:289560	48/89 (54%)
		ANK	560..684	CDD:238125	67/123 (54%)
		ANK repeat	564..593	CDD:293786	18/28 (64%)
		ANK 16	564..593		18/28 (64%)
		ANK repeat	597..626	CDD:293786	15/28 (54%)
		ANK 17	597..626		15/28 (54%)
		ANK repeat	630..660	CDD:293786	16/29 (55%)
		ANK 18	630..659		15/28 (54%)
		Ank_4	631..684	CDD:290365	27/52 (52%)
		ANK	658..783	CDD:238125	60/124 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		3/6 (50%)
		Ank_4	47..94	CDD:290365	26/48 (54%)
		ANK	68..193	CDD:238125	83/124 (67%)
		ANK repeat	73..104	CDD:293786	17/30 (57%)
		ANK 1	73..102		16/28 (57%)
		Ank_2	78..164	CDD:289560	54/85 (64%)
		ANK repeat	106..137	CDD:293786	20/30 (67%)
		ANK 2	106..135		19/28 (68%)
		ANK 3	139..168		19/28 (68%)
		ANK repeat	139..164	CDD:293786	17/24 (71%)
		Ank_4	140..193	CDD:290365	37/52 (71%)
		ANK 4	172..201		21/28 (75%)
		ANK 5	203..230		19/26 (73%)
		ANK repeat	205..232	CDD:293786	18/26 (69%)
		Ank_2	206..297	CDD:289560	60/90 (67%)
		ANK	229..354	CDD:238125	81/124 (65%)
		ANK repeat	234..265	CDD:293786	22/30 (73%)
		ANK repeat	663..694	CDD:293786	14/30 (47%)
		ANK 19	663..692		14/28 (50%)
		Ank_2	669..759	CDD:289560	42/89 (47%)
		ANK repeat	696..727	CDD:293786	15/30 (50%)
		ANK 20	696..725		15/28 (54%)
		ANK repeat	729..760	CDD:293786	12/30 (40%)
		ANK 21	729..758		12/28 (43%)
		Ank_5	749..803	CDD:290568	29/53 (55%)
		ANK 22	762..791		20/28 (71%)
		ANK repeat	762..790	CDD:293786	19/27 (70%)
		ANK 23	795..825		16/29 (55%)
		ZU5	982..1086	CDD:128514	63/103 (61%)
UPA domain. /evidence=ECO:0000250	1273..1407		70/133 (53%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1519..1540
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1968..1987
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2107..2159
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2176..2245
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2299..2322
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2383..2433
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2474..2508
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2588..2751
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2795..2824
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3036..3067
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3131..3272
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3298..3516
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3538..3607
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3635..3718
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3868..3897
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4019..4090
Death_ank3	4088..4171	CDD:176781
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4251..4298
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4323..4377
Ank	NP_001162819.1	ANK	67..192	CDD:238125	83/124 (67%)
		ANK repeat	72..103	CDD:293786	17/30 (57%)
		Ank_2	77..167	CDD:289560	56/89 (63%)
		ANK repeat	105..136	CDD:293786	20/30 (67%)
		ANK repeat	138..169	CDD:293786	21/30 (70%)
		ANK	204..320	CDD:238125	77/115 (67%)
		ANK repeat	204..231	CDD:293786	18/26 (69%)
		Ank_2	205..295	CDD:289560	59/89 (66%)
		ANK repeat	233..264	CDD:293786	22/30 (73%)
		ANK repeat	266..295	CDD:293786	17/28 (61%)
		ANK	294..419	CDD:238125	92/124 (74%)
		ANK repeat	299..330	CDD:293786	19/30 (63%)
		Ank_4	300..353	CDD:290365	33/52 (63%)
		ANK repeat	332..363	CDD:293786	17/30 (57%)
		Ank_2	337..428	CDD:289560	68/90 (76%)
		ANK	360..485	CDD:238125	89/124 (72%)
		ANK repeat	365..395	CDD:293786	26/29 (90%)
		ANK repeat	398..427	CDD:293786	24/28 (86%)
		ANK repeat	431..462	CDD:293786	18/30 (60%)
		Ank_2	436..526	CDD:289560	45/90 (50%)
		ANK repeat	464..494	CDD:293786	16/30 (53%)
		ANK	491..616	CDD:238125	62/124 (50%)
		ANK repeat	496..527	CDD:293786	16/30 (53%)
		Ank_2	501..592	CDD:289560	45/90 (50%)
		ANK repeat	529..560	CDD:293786	11/30 (37%)
		ANK	557..682	CDD:238125	67/124 (54%)
		ANK repeat	562..590	CDD:293786	18/27 (67%)
		Ank_5	582..636	CDD:290568	27/53 (51%)
		ANK repeat	595..625	CDD:293786	15/29 (52%)
		ANK repeat	628..657	CDD:293786	15/28 (54%)
		Ank_2	633..723	CDD:289560	44/90 (49%)
		ANK repeat	661..691	CDD:293786	14/30 (47%)
		ANK	692..812	CDD:238125	63/119 (53%)
		ANK repeat	693..724	CDD:293786	15/30 (50%)
		Ank_2	698..788	CDD:289560	44/89 (49%)
		ANK repeat	726..755	CDD:293786	12/28 (43%)
		ANK repeat	759..788	CDD:293786	20/28 (71%)
		ZU5	930..1034	CDD:128514	63/103 (61%)
		Death_ank	1439..1521	CDD:260029
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4788
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56908
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1011028at2759
OrthoFinder	1	1.000	-	-		FOG0000917
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	1	1.100	-	-	O	PTHR24133
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1361
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.780