DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ANK3 and nas6

DIOPT Version :10

Sequence 1:NP_066267.2 Gene:ANK3 / 288 HGNCID:494 Length:4377 Species:Homo sapiens
Sequence 2:NP_593722.1 Gene:nas6 / 2542919 PomBaseID:SPAC6C3.08 Length:234 Species:Schizosaccharomyces pombe


Alignment Length:225 Identity:65/225 - (28%)
Similarity:102/225 - (45%) Gaps:17/225 - (7%)


- Green bases have known domain annotations that are detailed below.


Human   373 VAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKH-GASIQAVTESGLTP 436
            :..:|....|.:.:.:...:.||...:..||||.||...::..:..|||. ........|:|.||
pombe    10 IEENCPEEYVEQAIQNDPNSLNAVDDDKRTPLHWACSVGKVNTIYFLLKQPNIKPDEKDEAGWTP 74

Human   437 IHVAAFMGHV--NIVSQLMHHG-ASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQ-VEAKAK 497
            :.::.....|  |::.:|::.. ..|..|...|:|.||.||..|:..:|:.|.....: :..|..
pombe    75 LMISINNRSVPDNVIEELINRSDVDPTITTRGGQTCLHYAAGKGRLSIVQLLCDKAPELIRKKDL 139

Human   498 DDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562
            ..|||||.:|.:||..:|:.|:.|.|..|.:.:.|:||||.:..|||.||...|:..||......
pombe   140 QGQTPLHRAAAVGKIQVVKYLISQRAPLNTSDSYGFTPLHFALAEGHPDVGVELVRAGADTLRKD 204

Human   563 KKGFTPLHV------------AAKYGKLEV 580
            .:..|.|.|            |.|...||:
pombe   205 SENHTALEVCPDRIVCNEFLEACKEQNLEI 234

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANK3NP_066267.2 ANKYR 1..305 CDD:440430
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44
ANK repeat 73..104 CDD:293786
ANK 1 73..102
ANK repeat 106..137 CDD:293786
ANK 2 106..135
ANK 3 139..168
ANK repeat 139..164 CDD:293786
ANK 4 172..201
ANK 5 203..230
ANK repeat 205..232 CDD:293786
ANK repeat 234..265 CDD:293786
ANK 6 234..263
ANKYR 248..536 CDD:440430 47/167 (28%)
ANK repeat 267..298 CDD:293786
ANK 7 267..296
ANK 8 300..329
ANK repeat 300..325 CDD:293786
ANK repeat 333..364 CDD:293786
ANK 9 333..362
ANK 10 366..395 2/21 (10%)
ANK repeat 369..397 CDD:293786 4/23 (17%)
ANK repeat 399..430 CDD:293786 9/31 (29%)
ANK 11 399..428 9/29 (31%)
ANKYR 413..701 CDD:440430 55/185 (30%)
ANK repeat 432..463 CDD:293786 7/33 (21%)
ANK 12 432..461 7/31 (23%)
ANK repeat 465..496 CDD:293786 9/31 (29%)
ANK 13 465..494 9/29 (31%)
ANK repeat 498..529 CDD:293786 13/30 (43%)
ANK 14 498..527 12/28 (43%)
ANK repeat 531..560 CDD:293786 13/28 (46%)
ANK 15 531..560 13/28 (46%)
ANK repeat 564..593 CDD:293786 7/29 (24%)
ANK 16 564..593 7/29 (24%)
ANK repeat 597..626 CDD:293786
ANK 17 597..626
PHA02875 605..>800 CDD:165206
ANK repeat 630..660 CDD:293786
ANK 18 630..659
ANK repeat 663..694 CDD:293786
ANK 19 663..692
ANK repeat 696..727 CDD:293786
ANK 20 696..725
ANK repeat 729..760 CDD:293786
ANK 21 729..758
ANK 22 762..791
ANK repeat 762..790 CDD:293786
ANK 23 795..825
ZU5 982..1086 CDD:128514
UPA domain. /evidence=ECO:0000250 1273..1407
UPA_2 1308..1437 CDD:375346
Herpes_BLLF1 <1393..1770 CDD:282904
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1519..1540
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..1987
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2107..2159
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2176..2245
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2299..2322
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2383..2433
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2474..2508
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2588..2751
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2795..2824
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3036..3067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3131..3272
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3298..3516
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3538..3607
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3635..3718
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3868..3897
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4019..4090
Death_ank3 4088..4171 CDD:176781
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4251..4298
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4323..4377
nas6NP_593722.1 ANKYR <19..211 CDD:440430 58/191 (30%)
ANK repeat 36..68 CDD:293786 9/31 (29%)
ANK repeat 71..104 CDD:293786 7/32 (22%)
ANK repeat 107..138 CDD:293786 9/30 (30%)
ANK repeat 140..171 CDD:293786 13/30 (43%)
ANK repeat 173..204 CDD:293786 13/30 (43%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.