DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ANK3 and set3

DIOPT Version :10

Sequence 1:NP_066267.2 Gene:ANK3 / 288 HGNCID:494 Length:4377 Species:Homo sapiens
Sequence 2:NP_594837.1 Gene:set3 / 2541899 PomBaseID:SPAC22E12.11C Length:859 Species:Schizosaccharomyces pombe


Alignment Length:953 Identity:204/953 - (21%)
Similarity:314/953 - (32%) Gaps:317/953 - (33%)


- Green bases have known domain annotations that are detailed below.


Human  1518 KSGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTTSSVKSISDVASPIRSFRTMSSPIK 1582
            :|...|.|.||:|....|..|:              |||.|.|       |||.:...|.::  .
pombe    72 QSRILSRSRSSNNKRRTSFGKN--------------GASPTHS-------ASPRQGNNTGAN--G 113

Human  1583 TVVSQSPYNIQVSSGTLARAPAVTEATPLKGLASNSTFSSRTSPVTTAGSLLERSSITMTPPASP 1647
            .:.|||..    ||.:.:...:||.||.....|.:|....|            ||:....||.:|
pombe   114 ALFSQSTN----SSNSGSYRNSVTGATLPNAHAPHSQNRRR------------RSNHLNNPPEAP 162

Human  1648 ---KSNINMYSSSLPFKSIITSAAPLISSPLKSVVSPVKSAVDVISSAKITMASSLSSPVKQMPG 1709
               .||..:||..|.:            .||:|         :..|::.:..:.:|.  :|.:  
pombe   163 ITEASNEYVYSFHLEY------------VPLES---------NTFSASALEYSKNLD--LKNL-- 202

Human  1710 HAEVALVNGSISPLKYPSSSTLINGCKATATLQEKISSATNSVSSVVSAATDT----VEKVFSTT 1770
                            ..|..|::||:.......|...:...:.|......:|    |:....|.
pombe   203 ----------------DESEVLMDGCQVVPISSSKFCCSRFGLVSTCEIPPNTPIMEVKGRVCTQ 251

Human  1771 TAMPFSPLRSY-VSAAPSA---FQS-------LRTPSASALYTSLGSSISATTSSV----TSSII 1820
            ......|...| :..||..   |.|       .|...:.|.:...|...::..|||    ::|:.
pombe   252 NEYKSDPKNQYNILGAPKPHVFFDSNSQLVVDSRVAGSKARFARKGCQSNSVVSSVYMNGSNSVP 316

Human  1821 TVPVYSVVNVLPE-------------PALKKLPDSN--SFTKSAAALLSPIKTLTT-----ETHP 1865
            ...:||..::.||             |..:..|..:  ||......|||.:  |:|     |...
pombe   317 RFILYSTTHIAPETEIIGDWTLDISHPFRQFAPGMSRPSFNMEELELLSEV--LSTFLSFNECAS 379

Human  1866 QPH----FSRTSSPVKSS---------------LFLAPSALKLSTPSSLSSSQEI---------- 1901
            |..    |||.:..:|::               |.|.||    ||||:.|.::.:          
pombe   380 QDKKNCVFSRVTKYIKAARRASTANRVSVAKDRLSLTPS----STPSTPSPAESLPQPSNPTSVY 440

Human  1902 LKDVAEMKEDLMRMTAILQ--------------TDVPEEKPFQPEL-PKEGRIDDEEPFKIVEKV 1951
            .|.:.|...|..|: :|||              .||..|...||.: .|:...|.:.|...||:.
pombe   441 AKSLKEFWLDKYRL-SILQKWPAVKSLPTESVGIDVVMEPKLQPSVKEKKPTKDLQSPLPSVEED 504

Human  1952 KEDLVKVSEILKKDVCVDNKG------SPKSP----KSD----KGHSPEDDWI------EFSSEE 1996
            ..:..|.::|  .|:..|:|.      ||.||    :||    |...||:..|      .|:..|
pombe   505 SSNRDKKTDI--ADLHTDSKVGIADVLSPISPDAALQSDGPLKKAKEPEESSITPTTPPSFNVGE 567

Human  1997 IREARQQAAASQSPSLPERVQVKAKAASEKDYNLTKV------IDYLTN---------------D 2040
             ..:|:.|:..|.|.....:..|..........:|.|      :|:|.:               |
pombe   568 -SLSRRSASPLQHPRTSPDMLDKTSPCKRGLGTITTVHKKHGSVDHLPSVKRRRSIANDFHGKPD 631

Human  2041 IGSSSLTNLKYKFEDAKKDGEERQKRVLKPAI-ALQEHKLKMPPASMRTSTSEKELCKMADSFFG 2104
            ....|| :::.|.|..|..|:...|  :.|:. ...:.|||:.|:|       ||  |....||.
pombe   632 YNKRSL-SIERKPEAFKTKGDRPHK--VHPSFHRNSDSKLKLEPSS-------KE--KSGSMFFN 684

Human  2105 TDTILESPDDFSQ-HDQDKSPLSDSGFETRSEKTPSAPQSAESTGPKPLFHEVPIPPVITETRTE 2168
            |   |.:..|.|. ||..:|  ||..| :|...|                               
pombe   685 T---LRTVKDKSHVHDTQRS--SDVNF-SRQNGT------------------------------- 712

Human  2169 VVHVIRSYDPSAGDVPQTQPEEPVSPKPSPTFMELEPKPTTSSIKEKVKAFQMKASSEEDDHNRV 2233
                 ||:.||...|..:..:.||:..|.||    .|.|                         |
pombe   713 -----RSHSPSVSPVGFSFDKSPVTTPPLPT----APAP-------------------------V 743

Human  2234 LSKGMRVKEETHITTTTRMVYHSPPGGEGASERIEETMSVHDIMKAFQSGRDPSKELAGLFEHKS 2298
            ::....:......|....::.|....|:             ||..|..:.|..:|..:.|.: .|
pombe   744 ITSRHALVNNQFPTNNPNILDHKANNGD-------------DISNALNTSRSENKPNSNLVQ-GS 794

Human  2299 AVSP-DVHKSAAETSAQHAEKDNQMKPKLERIIEVHIEKGNQA 2340
            .|.| :...||..|||......::.:.:.::.|.....|.|||
pombe   795 VVKPSNTSASALPTSAPKKLSLSEYRQRRQQNILHQQSKDNQA 837

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANK3NP_066267.2 ANKYR 1..305 CDD:440430
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44
ANK repeat 73..104 CDD:293786
ANK 1 73..102
ANK repeat 106..137 CDD:293786
ANK 2 106..135
ANK 3 139..168
ANK repeat 139..164 CDD:293786
ANK 4 172..201
ANK 5 203..230
ANK repeat 205..232 CDD:293786
ANK repeat 234..265 CDD:293786
ANK 6 234..263
ANKYR 248..536 CDD:440430
ANK repeat 267..298 CDD:293786
ANK 7 267..296
ANK 8 300..329
ANK repeat 300..325 CDD:293786
ANK repeat 333..364 CDD:293786
ANK 9 333..362
ANK 10 366..395
ANK repeat 369..397 CDD:293786
ANK repeat 399..430 CDD:293786
ANK 11 399..428
ANKYR 413..701 CDD:440430
ANK repeat 432..463 CDD:293786
ANK 12 432..461
ANK repeat 465..496 CDD:293786
ANK 13 465..494
ANK repeat 498..529 CDD:293786
ANK 14 498..527
ANK repeat 531..560 CDD:293786
ANK 15 531..560
ANK repeat 564..593 CDD:293786
ANK 16 564..593
ANK repeat 597..626 CDD:293786
ANK 17 597..626
PHA02875 605..>800 CDD:165206
ANK repeat 630..660 CDD:293786
ANK 18 630..659
ANK repeat 663..694 CDD:293786
ANK 19 663..692
ANK repeat 696..727 CDD:293786
ANK 20 696..725
ANK repeat 729..760 CDD:293786
ANK 21 729..758
ANK 22 762..791
ANK repeat 762..790 CDD:293786
ANK 23 795..825
ZU5 982..1086 CDD:128514
UPA domain. /evidence=ECO:0000250 1273..1407
UPA_2 1308..1437 CDD:375346
Herpes_BLLF1 <1393..1770 CDD:282904 53/258 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1519..1540 8/20 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..1987 10/32 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2107..2159 11/52 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2176..2245 11/68 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2299..2322 7/23 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2383..2433
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2474..2508
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2588..2751
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2795..2824
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3036..3067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3131..3272
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3298..3516
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3538..3607
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3635..3718
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3868..3897
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4019..4090
Death_ank3 4088..4171 CDD:176781
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4251..4298
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4323..4377
set3NP_594837.1 PHD_MLL5 5..48 CDD:277025
SET_SpSET3-like 215..387 CDD:380960 33/173 (19%)
Blue background indicates that the domain is not in the aligned region.

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