DRSC/TRiP Functional Genomics Resources

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Protein Alignment ANK3 and unc-44

DIOPT Version :10

Sequence 1:NP_066267.2 Gene:ANK3 / 288 HGNCID:494 Length:4377 Species:Homo sapiens
Sequence 2:NP_001367345.1 Gene:unc-44 / 177366 WormBaseID:WBGene00006780 Length:6994 Species:Caenorhabditis elegans


Alignment Length:5562 Identity:1544/5562 - (27%)
Similarity:2287/5562 - (41%) Gaps:1613/5562 - (29%)


- Green bases have known domain annotations that are detailed below.


Human     7 QLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICN 71
            |.::....|:.|...||..|            ::.:||:|||||||.|||.|:.::.|.|||..|
 Worm    11 QQQQPESQEVQAPAAPEPGR------------AEGSASFLRAARAGDLEKVLELLRAGTDINTSN 63

Human    72 QNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136
            .||||:|||||||||.|||.||::|:|.|||||:||||||||||||||:.:|.:||.||||||.|
 Worm    64 ANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQ 128

Human   137 SQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKV 201
            |.||||||||||||||.||||:||.:||:|:|:|||||||||||||||||:||::|||||:||||
 Worm   129 SVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLENDSKGKV 193

Human   202 RLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTAR 266
            |||||||||:||||.||.|||||::|.||.|||||||||||||||:.||..|||.:.|.|::.||
 Worm   194 RLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQAR 258

Human   267 NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT 331
            ::|:|||||:|.|..||..|||.|||.||::|:|.||||||.|||||:|||::|:.:.|||.:||
 Worm   259 HNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKT 323

Human   332 KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAK 396
            ||||:|||||.||||::..:.||.|..||||||.||||.|||||||||.:|||:|||:.|:||::
 Worm   324 KNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSR 388

Human   397 ALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461
            |||||||||||||||||||:|||||:.|:|:|.|||||||:|||||||.:|||..|:..||:|:.
 Worm   389 ALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDV 453

Human   462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526
            ..|||||.||:|||:.|.:|||.|:::||:|:|:|::.||||||::|||..|||..|||.||:.|
 Worm   454 ETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSN 518

Human   527 AATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP 591
            |.|...|:|||::|:||.|:||..||||.|..::.|||||||||:|:|||.|||..|||::....
 Worm   519 ATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLERGTPV 583

Human   592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD 656
            |..||:.:|||||||||:|.|||:|||:.|||..|||||||||||||||||||:||:|||::.||
 Worm   584 DIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQFKAD 648

Human   657 ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721
            .||.:|.|...:||:|||||.::..||:...::|.....:|||.:||.||||.|.||::|.|.||
 Worm   649 PNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGA 713

Human   722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNN 786
            .::::|..|||||||.||:|.:.:|.||:::.|.|..||:..||||||||||||.:.:..||:|.
 Worm   714 EINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENG 778

Human   787 ASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETM--TTTTVTEKHKMNVPETMNEVL-DMSD 848
            |||||.|..|.|.|.||:||||:|||:||:.|||.|:  .||||.|::|...||.|||.: ..|:
 Worm   779 ASPNEQTATGQTPLSIAQRLGYVSVVETLRTVTETTVITETTTVDERYKPQNPEAMNETMFSESE 843

Human   849 DEVRKA--------------NAPEMLSDGEYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLPA 899
            ||.:.|              |..:.|.|...:..:..||..:...       |:|:..|  ::|.
 Worm   844 DEGQAAEHEAVAAHEKDFSDNLTQGLQDSTGVHMIHTGEQLLQRS-------QELENGG--AIPK 899

Human   900 EGYMGFSLGARSASLRSF-SSDRSYTLNRSSYA----------------------RDSMMIEELL 941
            ....|.|.....|.:... :|....|.|..|:.                      .|::   |.|
 Worm   900 INSGGMSPEKEFAKIAPVATSSPIATSNSQSFGIAPRAGSISGQFQQQPLHGAGPEDNL---EEL 961

Human   942 VPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPI-----------HSGFLVSFMVDARGG 995
            |...:.|......:|:..:.       .|:|.:..:.||           |..||:||:||||||
 Worm   962 VRRAQNHPINAGNYDNGGVA-------MLENGHADNVPIGHHVTQPSKLQHRTFLISFLVDARGG 1019

Human   996 SMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPV 1060
            :|||.||.|:|||:||||.:.|.|:|||.:::.|||:|||:.|||.||||::||.||||:|||||
 Worm  1020 AMRGCRHSGVRIIVPPRKASQPIRVTCRYLRKDKLAHPPPLSEGEELASRILEMAPAGAKFLGPV 1084

Human  1061 IVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLN-GMD-EELDSPEELGKKRIC 1123
            |:|:|||.|:|.:|||:::|||::|:.|||||.::..:.:.|:|| ..| |:|...::|...||.
 Worm  1085 ILEVPHFASLRDREREIVILRSDDGQHWKEHQLEATEDAVQEVLNESFDAEDLAQLDDLQTPRIT 1149

Human  1124 RIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEI 1188
            ||:|.|||.|||||:|::||.:.:|||||::.|:.||.|||.||:|:|||.|:|.:||||||.|:
 Worm  1150 RILTSDFPMYFAVVTRVRQEVHCVGPEGGVIISSVVPRVQAIFPDGSLTKTIKVSVQAQPVPQEM 1214

Human  1189 VKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGV---SNGYKGDTTPNLRLLCSITG 1250
            |.::.||:...||||||||||||||||||:.||:|..:..|:   .:|.:|...|.|||||||||
 Worm  1215 VTRLHGNRVAVSPIVTVEPRRRKFHKPITLCIPLPQSNNRGMLTQYSGQQGQEPPTLRLLCSITG 1279

Human  1251 GTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPYMAKFV 1315
            |::|||||||||||.|||..|.|||||.|||||||.||....:...:|.::|.|.|.:||||||.
 Worm  1280 GSAPAQWEDITGTTQLTFTGDEVSFTTTVSARFWLMDCQTPRDAARMAQEVYNEAISIPYMAKFA 1344

Human  1316 VFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGG 1380
            |||:...|||..||.|||||||.|||||:||:|:.:|:|:|:|||:||..:::..|||.|:||.|
 Worm  1345 VFARRTFPVEGQLRVFCMTDDKEDKTLEKQEHFKLIAKSRDVEVLKGKHQFLEFSGNLVPITKSG 1409

Human  1381 QQLVFNFYSFKENRLPFSIKIR---DTSQEPCGRLSFLKEPKTTKGL--PQTAVCNLNITLPAHK 1440
            .||...|..|:||||.|.:|.|   |......||:.|:.|||.....  ||..:|.|.|:||.:.
 Worm  1410 DQLSLFFLPFQENRLAFMVKTRSNDDNEAATEGRIGFMAEPKIRSDALPPQQPICTLAISLPEYT 1474

Human  1441 KETESDQDDEIEKTDRRQSFASLALRKRYSYLTEPGMIERSTGAT-----RSLPTTYSYKPFFST 1500
            .|.::....:.:.|...|.:.| ||.|.........:: :..||.     |:|..          
 Worm  1475 GEIKTAPPPKKDLTPFEQRYGS-ALEKDLPEFVHQNVL-KGIGADWPRLGRALEV---------- 1527

Human  1501 RPYQSWTTAPITVPGPAKSG----FTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTL-----GAS 1556
             |::.........||.....    :..|....:|..:..  :::..:.....::|..     ...
 Worm  1528 -PHRDIQHIRQNYPGQECKNTLKIWIHLKKEDANQDNLD--QALRQIGRDDIVRSIAYGEPDALI 1589

Human  1557 TTSSVKSISDVASPIRSFRTMSS-----------------PIK---------TVVSQSPYNIQVS 1595
            ..|...|.|....|||.|..:.:                 |::         |||.:..|:..|.
 Worm  1590 NYSQADSPSQKREPIRHFEEVPAATLVKREVRTEDLVTREPVQPTHHVEQATTVVQEPSYSAPVH 1654

Human  1596 SGTLARAPAVTEATPLKGL-----ASNSTFSSRTSPVTTAGSLLERSSITMTPPASPKSNINMYS 1655
            ...:...|.:.|..|:..:     .......|...||      :|..:||.|.......|.|:..
 Worm  1655 HSPVPEEPEMEEEAPVAEMRTVVRTERHVHDSEDGPV------VEERTITTTYEDDVAVNENIVD 1713

Human  1656 SSLPFKS-----------IITSAAP--------LISSPLKSVVSPVKSAVDVIS----SAKITMA 1697
            .::|...           :...::|        :..|..:.|...|:.:|:..|    ...|...
 Worm  1714 RTVPLNEDEQQKWEELNRLADESSPSPAQRSTIVAESTSEQVPEDVEQSVESESHREDDGTIVTT 1778

Human  1698 SSLSSPVKQMPGHAEVALVNGSISPLK--------YPSSSTLINGCKATATLQEKISSA---TNS 1751
            :..:|.:.:.|..:.   ...|:.|.:        :.:|....:..:.:.|.|:|.::.   ||.
 Worm  1779 TVTTSHISESPSGSP---TRRSVEPEEHRHSQHEDHEASGAEQHSGQDSGTTQKKETAEEGFTNE 1840

Human  1752 VSSVVSAATDTVEKVFSTT----------TAMPFSPLRSYVSAAP--SAFQSLRT----PSAS-- 1798
            ..|||  .:..:.:|.:||          .:.|.||:.|..|...  :.|:..:|    ||.|  
 Worm  1841 DGSVV--VSKKMTRVVTTTRTTLPGEGEEPSAPDSPVESLGSVKDRIAKFEQFKTLPIDPSVSGP 1903

Human  1799 --ALYTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPALKKLPDSNSFTKSAAALLSPIKTLTT 1861
              :.:|.........:.:|.|:      |.|..        ...||....||..: :..|.|..:
 Worm  1904 PPSAHTLQSEEYQEESGNVESA------YDVET--------DRRDSERSLKSERS-IPEIHTSPS 1953

Human  1862 ETHPQPHFSRTSSPVKSSLFLAPSALKLSTPSSLSSSQEILKDVAEMKEDL---------MRMTA 1917
            |.....||..........   ..|...|.:..|:...|....|....|.||         :.:..
 Worm  1954 EEQQSEHFESAEHTEDQG---RDSGRSLKSDRSIPEVQFTESDSELEKHDLHEDSHLEPTVGIVI 2015

Human  1918 ILQTDVPEEKPFQPELPKEGRIDDEEPFKIVEKVKEDLVKVSEILKKDVCVDNKGSPKSPKSDKG 1982
            ...|.||.|.|...|     .|:||:|.:.:|                        |..|: ...
 Worm  2016 TPHTPVPPEHPDDKE-----DIEDEQPQEPLE------------------------PSEPE-HVA 2050

Human  1983 HSPEDDWIEFSSEEIREARQQAAASQSPSLPERVQVKAKAASEKDYNLTKVIDYLTNDIGSSSLT 2047
            |:...|..|:|.||:       |...||             ||:..:..::     .||.|.|.|
 Worm  2051 HAELKDTREYSDEEL-------AQELSP-------------SEEHVSTAEI-----KDIKSYSPT 2090

Human  2048 NLKYKFEDAKKDGEERQKRVLKPAIALQEHKLKMPPASMRTSTSEKELCK--MADSF-----FGT 2105
                    :..|....||..:.|.|....|.:....||...|:.:.||..  :|:||     ...
 Worm  2091 --------SSDDERSSQKGKVSPPIPQVRHAISPSVASEVLSSHDDELAAHFVAESFEKHDEGNV 2147

Human  2106 DTILESP-------------------------DDFSQHDQDKSPLSDSGFETR------------ 2133
            :||.::|                         :..:.||:..:....||.|..            
 Worm  2148 ETIEQTPVYKGHHSPGQTSPIVSEHPHAQEYAESVTSHDEGDNLSLKSGHEPEIARHSVASVQEE 2212

Human  2134 ----SEKTP----------------SAPQSAESTGPK---------------------------- 2150
                .||:.                :||.:..:.|.|                            
 Worm  2213 DDDDDEKSELGDFAKKAGMIVGGVIAAPVALAAVGAKAAYDALNRDDDEEKLEGHEEKEVLTTQT 2277

Human  2151 -----PLFHE-VPIPPV----------------ITETRTEVVHVIRSYDPSAGDVPQTQP----- 2188
                 |:.|| :|.|.:                :|||.|.|.   |.|.....|..:..|     
 Worm  2278 TIMESPIRHEDIPSPHLEDVTPKVSHQEHPYEHVTETTTTVT---RDYYEQPEDHREASPAPSSH 2339

Human  2189 ---EEPVSPKPS-----PTFM------------ELEPKPTTSSIKEKVKAFQMKASSEEDDH--- 2230
               |.|:|..|:     |:.:            :.|||...||.:|.|:    ...|||.:|   
 Worm  2340 VESERPISESPAVSEREPSHIATETTTTVTREYDQEPKADQSSARESVR----DLVSEEHEHPAC 2400

Human  2231 -NRVLSKGMRVKE--ETHI---------TTTTRMV---YHSPPGGEGAS-----ERIEET----- 2270
             :..||:..:..|  |||.         ||||..|   ::.....|.||     ||||::     
 Worm  2401 DSERLSEPAQSPEPVETHAESQFSNLVETTTTTAVTREFYDEDQEEQASSRATKERIEQSPVASE 2465

Human  2271 -------------------------MSVHDIMKAFQSGRDPSKE-LAGLFEHKS----------- 2298
                                     .:||.:.:.....|:..:| :|...||.|           
 Worm  2466 RSIVSTEHRQSPTQESEQSLEPTSEKNVHTVTETTTVTRECFEEPIASELEHASREFEQGSNDFR 2530

Human  2299 -AVSP-------DVHKSAAETSAQHAEKDNQMKPKLERIIEV----------------------- 2332
             :|||       ||..|.|.:|  |||.:..:......|:|.                       
 Worm  2531 RSVSPVDAQEQVDVPHSPAPSS--HAESEQPVPESPHHIVETTTTTTVTREFQDEEYPRPESPAE 2593

Human  2333 --------------HIEKGNQAEPTEVIIRETKKHPEKEMYVY----------QKDLSRGDI--- 2370
                          ||.|  :...|..:.||....|||....:          ::.:....:   
 Worm  2594 IFPIPSSEQQSEEPHIVK--ETTTTTTVTRELYDEPEKGNVTFSPAPSSHAESERQVPESPVVSH 2656

Human  2371 -------------NLKDFLPEKHDAFPCSEEQGQQ--EEEELTAEESLPSYLESSR--------- 2411
                         |:...:.:..|..|.||:...|  ::.|.:...|.|..:|.|.         
 Worm  2657 QEYPHVVETTTTTNVTSNIYDDEDNVPSSEDPATQHFQQSETSVHRSHPDSVEESDGEGLGSKVL 2721

Human  2412 -------------VNTPVS---------------QEEDSRPS----------SAQLISDDSYKTL 2438
                         |..||:               .:||...|          .::...|||.::.
 Worm  2722 GFAKKAGMVAGGVVAAPVALAAVGAKAAYDAFEKDDEDDETSHSPESPVPEYQSEQYQDDSAQSS 2786

Human  2439 KLLSQH-----SIEYHDDELSELRGESYRFAEKMLLSEKLDVSHSDTEESVT------------- 2485
            ....:|     .|| |:.|..|.   .:...|..:|||| :..|..|.|:.|             
 Worm  2787 HTDFEHHMPESPIE-HEKETEEF---DHSHPESPVLSEK-EREHQVTSETTTTTTVTREYNDEPE 2846

Human  2486 ---DHAGP----PSS---------------------------ELQGSDKRSREKIATAPKKE--- 2513
               :|.||    |||                           ||:...:.:..|..::..:|   
 Worm  2847 DEQEHQGPHSPAPSSHTEAEHPHIVETTTTTTVTREFQEEPEELEYKQEDNSRKSPSSHSQENLV 2911

Human  2514 --------ILSKIYK-----DVSENGVGKVSKDEHFDKVTVLHYSGNVSSPKHAM--------WM 2557
                    :.|:.|.     :..|.|....:...|.:....:..|...|.|:|.|        ..
 Worm  2912 TETTTTTTVTSEYYDEPEHFEEQETGKSSPAPSSHVESERQVLESPVASDPRHVMETTTTTTVTR 2976

Human  2558 RFTEDRLDRGREKLIYEDRVDRTVKEA-------------------------------------- 2584
            :|.:|..:|       .|..:|.|.||                                      
 Worm  2977 QFHDDESER-------SDSPNRDVVEAQSIHSSNIESHQQFSEKDDDSQRGPSPVKSEDEPVKHE 3034

Human  2585 ----EEKLTEVSQFFRDK--TEKLNDELQSP---------EKKARPKNG--KEYSSQSPTSSSPE 2632
                |...||..:|.|.:  :|:|::..|||         |...||.:.  .||.|:....|..|
 Worm  3035 SYKFETSTTETREFDRPELDSERLSEPAQSPMEVSPITTEENIVRPSSSVKSEYGSEGHVPSVIE 3099

Human  2633 KVLLTELLASNDEWVKARQHGPDGQ----GFPKAEEKAPSLPSSPEKMVLSQQTEDSKSTVEAKG 2693
            ....|.:         .|:...|.|    ...::||...|:|:..|:...|...:::.:|.....
 Worm  3100 TKTTTTV---------TREFYDDDQDEHENQTQSEELRSSIPTEEEEHEGSHLFKETTTTTTVTR 3155

Human  2694 SISQSKAPDGPQSGFQLKQSKLS-SIRLKFEQGTHAKSKDMSQEDRKSDGQSRIPVKKIQESKLP 2757
            ...     |.|::..:|:..:.| :.....|.|.||....::|       |..||..:......|
 Worm  3156 EFY-----DEPENVEELQDPQFSPAPSSHVESGIHASESPVAQ-------QQEIPQTREFHEDSP 3208

Human  2758 VYQVFARE---------------KQQKAIDLPDES------------------------------ 2777
            ..|.|..|               :||...:..|||                              
 Worm  3209 AAQYFHEEEYESHVLTEQAPLLTEQQHQPESGDESDGEGLGSKVLGFAKKAGMVAGGVVAAPVAL 3273

Human  2778 --VSVQKDFMVLKTKDEHAQSNEIVVNDSGSDNVKKQRTEMSSKAMPDS--------FSEQQAKD 2832
              |..:..:..||..|:.....|      ....::::|:..|..|...|        |.|.....
 Worm  3274 AAVGAKAAYDALKKDDDEEDQEE------RESLLRQERSIDSPHASEQSQIEEEHERFEESPVPS 3332

Human  2833 LACHI----TSDLATRGPWDK-KVFRTWESSGATNNKSQKEK-LSHVLVHDVRENHIGHPESKSV 2891
            ...|:    |:...||..:|: :...:.|..|...:.:..|| |.||:                 
 Worm  3333 EKHHVTETTTTTTVTREYFDEHEPLVSQEIEGEKGSPADSEKSLPHVV----------------- 3380

Human  2892 DQKNEFMSVTERERKLLTNGSLSEI---KEMTVKSPSKKVLYREYVVKEGDHPGGLLDQPSRRSE 2953
                |..:.|...|:...|.|.|.:   ||....:.|::|    |...||       |:|.....
 Worm  3381 ----ETTTTTTVTREFDKNDSESPVPSEKEQEPTTVSREV----YETAEG-------DEPEHHYT 3430

Human  2954 SSAVSHIPVRVADERRMLSSNIPDGFCEQSAFPKHELSQKLSQSSMSKETVETQHFNSIEDEKVT 3018
            .:..:.:...|.|:.:.:..:..         ||.|..|.:..::   .|:.::.::..:||  |
 Worm  3431 ETTTTTVTKEVIDDSQEMGDDDE---------PKQESPQVVETTT---TTMTSREYDDNDDE--T 3481

Human  3019 YSE-----ISKVSKHQSYV----GLCPPLEETETSPTKSPDSLEFSPGKESPSSDVFDHSPIDGL 3074
            .||     |::.:|..:.|    |..|  ||||.:     |.:|..|.|.....:|.::|.    
 Worm  3482 RSEAGDSHITETTKTTTVVREFHGEQP--EETEET-----DEVEELPPKIEEEDNVSEYSE---- 3535

Human  3075 EKLAPLAQTEGGKEIKTLPVYV----SFVQVGKQYEKE------IQQGGVKKIISQEC------- 3122
                  :.|...:|::....::    :...|.::|..|      .|:.......|||.       
 Worm  3536 ------SSTSVSREVRPDEPHIIETTTTTTVTREYHNEPEETYDDQKDAAPISFSQEHQDDDSQA 3594

Human  3123 --------------KTVQETRGTFYTTRQQKQPPSPQGSPEDDTLEQVSFLDSSGKSPLTPETPS 3173
                          |:|:.|..|..||...:|       ..||...::     .|:||:     :
 Worm  3595 SHDQHDRESPVESEKSVKHTTETTTTTTVTRQ-------LYDDEASEI-----RGESPV-----A 3642

Human  3174 SEEVSYEFTSKTPDSLIAYIPG-------------------------------KPSPIPEVSEES 3207
            :||..:..::|:.|....::|.                               :.|.||  :||:
 Worm  3643 TEEHEHVSSTKSDDESEQHVPSVIETTTTTTVTREFYDDQDELQREDHTQSEERRSSIP--TEET 3705

Human  3208 EEEEQAKSTSLKQTTVEETAVEREM---PNDVSK--DS--NQRPKNNRVAYIEFPPPPPLDADQI 3265
            |.|:   |..:|:||. .|.|.||.   |.:|.|  ||  :..|.::..:.|..|..|.....:|
 Worm  3706 EHED---SHLIKETTT-TTTVTREFYDEPENVEKLQDSQFSLSPSSHVESEIYVPESPVAKQQEI 3766

Human  3266 ----------------ESDKKHHYLPEKEVDMI-------------------------------- 3282
                            ..|:..|.:|.::..::                                
 Worm  3767 PQTREFHEDSPAAQYFHEDEYEHQVPTEQAPLLTEQQHQPESGEESDGEGFGSKVLGFAKKAGMV 3831

Human  3283 ---------------------EVNLQDEHDKYQLAEPVIRVQ---------------------PP 3305
                                 .:..:|:.:..:..|.:||.:                     ..
 Worm  3832 AGGVVAAPVALAAVGAKAAYDALKKEDDEEDQEERESLIREERSFDSPHASEQSQIEKEHKRFEE 3896

Human  3306 SPVPPGA--DVSDSSDDESIYQPVPVKKYTFK-----------LKEVDDEQKEKPKASAEKAS-- 3355
            ||||...  |.|.:...||:.||:..:..||.           ..|.|.|..:.||.|.|..|  
 Worm  3897 SPVPSEKHHDQSSALPQESVSQPIEKESRTFNDESEFGVKSDHYTEDDQESLKSPKESGEAFSQF 3961

Human  3356 -NQKELESNGSGKDNEFGLGLDSP---QNEIAQNGNNDQSITECSIATTAEFSHDTDATEIDSLD 3416
             ::||.:.:            |||   |.|......|:.|..:    ..:|..||.:..:::...
 Worm  3962 TSEKEQDRS------------DSPIHSQKEDISQFQNESSPED----VKSEQPHDEEKPDLERQG 4010

Human  3417 GYDLQDEDDGLTESDSKLPIQAMEIKKDIWNTEGILKPADR--SFSQS--KLEVIEEEGKVGPDE 3477
            .|     ..|.:.......|..::.:|.:   .|:.:|.||  :|::|  |.|...:|.....|:
 Worm  4011 SY-----SSGYSPKSPGGSITGLDEEKAL---SGVQEPEDRPENFAESHEKTEATSDENLFESDK 4067

Human  3478 DKP----PSKSSS----------------------------------------SEKTPDKTDQKS 3498
            ..|    ||:.||                                        |||:.|:..:.:
 Worm  4068 YAPASPVPSEDSSNRVIETTTTTTVTREHFEPEDDHSYVVESQEYSSSGSPVPSEKSVDRVIETT 4132

Human  3499 GAQFFT-------------LEGRHPDRSVFPDTYFSYKVDEEFATPFKTVATKGLDFDPWSNNRG 3550
            .....|             :|..|.|::..| ......|.|:..|...|.......|.|      
 Worm  4133 TTTTVTREHFEAEDEIPTIVESSHDDQAASP-VPSEEDVHEQIQTTTTTTTVTKEHFVP------ 4190

Human  3551 DDEVFDSKSREDETKPFGLAV---EDRSPATTPDTTPART-----PTDESTP-------TSEPNP 3600
            |||:......|.:....|..|   ||.|..|...||...|     |.|:.:|       ::..:|
 Worm  4191 DDEIDSEHMNESDKYASGSPVPSEEDSSRVTETTTTTTVTREHFEPEDDHSPVVQTQEYSASESP 4255

Human  3601 FPFHEG--KMFEMTRSGAIDMSKRDFVEERLQFFQIGEHTSEGKSGDQGEGD-----KSMVTATP 3658
            .|..:.  ::.|.|.:..:  ::..|.:|        :|.    .|.|||.|     :|:.:...
 Worm  4256 VPSEKSVERVIETTTTTTV--TREHFEDE--------DHI----LGQQGESDSQIPSESITSENM 4306

Human  3659 QPQSGDTTVETNLERNVETPTVEP--------------NPSIPTSG-----------ECQEGTS- 3697
            ..::..:.|::|.:.....|.:.|              .|:.|...           |.||..| 
 Worm  4307 DRETSSSPVQSNRDEEFVLPAIAPYKQPTEYGRVDSHDAPASPAPSAESPIQAYKQEESQEAHSL 4371

Human  3698 ------SSGSLEKSAAA----TNTSKVD---PKLRTPIKM---------------GISASTMTMK 3734
                  ||.|.|.|.||    .|.|..|   |..|.|:..               |..:..:...
 Worm  4372 EQFQQRSSVSHEDSPAAQYFHDNESDHDSPVPSDRAPLLTEQQHQPESGEESDGEGFGSKVLGFA 4436

Human  3735 KEGPGEITDKIEAVMTSCQGL----------------EN--ETITMISNTANSQMGVRPHEKHDF 3781
            |:. |.:...:.|...:...:                ||  |...::..:...|:.|.|.|..|.
 Worm  4437 KKA-GMVAGGVVAAPVALAAVGAKAAYDALKKDDDEDENPDEQEKLLPKSPERQVLVNPVEPSDS 4500

Human  3782 QKDNF-----------NNNNNLDSSTIQTDNIMSNIV----------------LTEHSAPTCTTE 3819
            :....           .:.:...:.|::|..:....:                ::|..||....|
 Worm  4501 EISEIELEYTSPSPTEKSESQCYTETVRTTTVTREYLDDPQSVTRSRSPSEHDISEQYAPESPVE 4565

Human  3820 KDNPVKVSSGKKTGVLQGHCVRDKQKVLGEQQKTKELIGIRQKSKLPIKATSPKDTFPPNHMSNT 3884
            :| |..|.  |.|.|::.:.....|:: .||...:|:..:|:..:      ||:...|..|...|
 Worm  4566 QD-PYVVE--KTTTVIRQYHDEPPQEI-EEQTIPEEVTVLREVYE------SPEGDEPEQHYIET 4620

Human  3885 KASKMKQVSQSEKTKALTTSSCVDVKSRIPVKNTHRDNIIAVRKACATQKQGQPEKGKAKQLPSK 3949
            |.           |..:|....|.|:..:.:...|.:..::.::..|.::..:|           
 Worm  4621 KT-----------TTTITKEVHVPVEEDVQISPVHSETSVSEKQLPADEQLDEP----------- 4663

Human  3950 LPVKVRSTCVTTTTTTATTT----------------------------TTTTTTTTTSCTVKVRK 3986
                     ||.:|||||.|                            .||||||.|      |:
 Worm  4664 ---------VTESTTTATVTRERYEEPEEVRPPSGSEADDESHAPKYMETTTTTTVT------RE 4713

Human  3987 SQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSLSETSRGGQPSVTT 4051
            .::.|                        :|::..||::..:|.......|:.........:..|
 Worm  4714 YEVSE------------------------DEDEHQQSQVQRDESPAPSEDSVKHVIEKTTTTTVT 4754

Human  4052 KSARDKKTEAAPLKSKSEKAGSEKRSSRRT--------------------------GPQSPCERT 4090
            :...:.:...:|:.|:.:..|..|.::..|                          |...|.|..
 Worm  4755 EERYEPEDSHSPVPSEDDVHGFVKTTTTTTTVTHEHFEPEDPPSDEHVVESERYASGSPVPSEED 4819

Human  4091 DIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALT 4155
            ..|.....     :.|.:.|| :|.:::..:..||:.....|.|.:..:|.|.|..:..||:.:|
 Worm  4820 SSREIETT-----TTTTVTRE-HFELEDDQEHVVESQEYSASGSPVPSEKSVERVIETTTTNTVT 4878

Human  4156 SVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGWQNETSSGNL--ESCAQARRV 4218
            ....: :..||.|::|....|    ....|...|.:| |..:   |..|::..:  |.......:
 Worm  4879 REHFE-HEDDIPTIVETSHDD----PAASSVPSEEDV-HGQI---QTTTTTTTVTREHVVPDEEI 4934

Human  4219 TGGLLDRLD----DSPDQCRDSITSYLKG---------------------EAGKFEANGS----- 4253
            ..|.:|.|:    :||....:..:..::.                     |:.::.|:||     
 Worm  4935 DSGRMDELEKYSSESPVPSEEDSSRVIETTTTTTVSREHFEPEDDHSHVVESQEYSASGSPVPSE 4999

Human  4254 --------------------HTE---ITPEAKT-------------KSYFPESQND--------- 4273
                                .||   |..|::|             :|..|..::|         
 Worm  5000 KSVERVIETTTTTTVTREHFDTEEDYIPSESRTSHDDGITDQHVPSQSPVPSEEDDHVTHEQIIR 5064

Human  4274 ---VGKQSTK------ETLKPKIHGSGHVEEP--ASPLAAYQKSLEETSKLIIEETKPCVPVSMK 4327
               :.:|..:      |:..|....|.||.|.  ::|:.: ::...|..|.::|.....:..|..
 Worm  5065 DDPIDEQIVESHEYKSESSIPSEQDSTHVIETVMSTPITS-ERYDPEVEKDVVESADDEIDSSTA 5128

Human  4328 KMSRT-SPADGKPRLSLHEEEGSSGSEQKQGEGFKVK 4363
            :..:: ||...:..|.|.:::..||.| ..||||..|
 Worm  5129 QYYKSESPVQTEKSLLLAKQQQESGDE-SDGEGFGSK 5164

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANK3NP_066267.2 ANKYR 1..305 CDD:440430 195/297 (66%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44 6/36 (17%)
ANK repeat 73..104 CDD:293786 23/30 (77%)
ANK 1 73..102 21/28 (75%)
ANK repeat 106..137 CDD:293786 23/30 (77%)
ANK 2 106..135 22/28 (79%)
ANK 3 139..168 23/28 (82%)
ANK repeat 139..164 CDD:293786 20/24 (83%)
ANK 4 172..201 24/28 (86%)
ANK 5 203..230 20/26 (77%)
ANK repeat 205..232 CDD:293786 20/26 (77%)
ANK repeat 234..265 CDD:293786 20/30 (67%)
ANK 6 234..263 20/28 (71%)
ANKYR 248..536 CDD:440430 182/287 (63%)
ANK repeat 267..298 CDD:293786 18/30 (60%)
ANK 7 267..296 17/28 (61%)
ANK 8 300..329 19/28 (68%)
ANK repeat 300..325 CDD:293786 16/24 (67%)
ANK repeat 333..364 CDD:293786 19/30 (63%)
ANK 9 333..362 17/28 (61%)
ANK 10 366..395 21/28 (75%)
ANK repeat 369..397 CDD:293786 19/27 (70%)
ANK repeat 399..430 CDD:293786 25/30 (83%)
ANK 11 399..428 24/28 (86%)
ANKYR 413..701 CDD:440430 171/287 (60%)
ANK repeat 432..463 CDD:293786 19/30 (63%)
ANK 12 432..461 19/28 (68%)
ANK repeat 465..496 CDD:293786 18/30 (60%)
ANK 13 465..494 17/28 (61%)
ANK repeat 498..529 CDD:293786 19/30 (63%)
ANK 14 498..527 17/28 (61%)
ANK repeat 531..560 CDD:293786 15/28 (54%)
ANK 15 531..560 15/28 (54%)
ANK repeat 564..593 CDD:293786 17/28 (61%)
ANK 16 564..593 17/28 (61%)
ANK repeat 597..626 CDD:293786 19/28 (68%)
ANK 17 597..626 19/28 (68%)
PHA02875 605..>800 CDD:165206 111/194 (57%)
ANK repeat 630..660 CDD:293786 23/29 (79%)
ANK 18 630..659 22/28 (79%)
ANK repeat 663..694 CDD:293786 11/30 (37%)
ANK 19 663..692 11/28 (39%)
ANK repeat 696..727 CDD:293786 16/30 (53%)
ANK 20 696..725 16/28 (57%)
ANK repeat 729..760 CDD:293786 15/30 (50%)
ANK 21 729..758 15/28 (54%)
ANK 22 762..791 18/28 (64%)
ANK repeat 762..790 CDD:293786 17/27 (63%)
ANK 23 795..825 18/31 (58%)
ZU5 982..1086 CDD:128514 65/103 (63%)
UPA domain. /evidence=ECO:0000250 1273..1407 74/136 (54%)
UPA_2 1308..1437 CDD:375346 67/133 (50%)
Herpes_BLLF1 <1393..1770 CDD:282904 84/460 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1519..1540 2/24 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..1987 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2107..2159 18/142 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2176..2245 23/99 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2299..2322 11/29 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2383..2433 15/98 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2474..2508 13/80 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2588..2751 40/180 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2795..2824 4/28 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3036..3067 10/30 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3131..3272 40/194 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3298..3516 61/318 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3538..3607 20/85 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3635..3718 28/126 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3868..3897 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4019..4090 13/96 (14%)
Death_ank3 4088..4171 CDD:176781 19/82 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4251..4298 17/107 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4323..4377 13/42 (31%)
unc-44NP_001367345.1 ANKYR <22..219 CDD:440430 144/208 (69%)
ANK repeat 32..63 CDD:293786 17/30 (57%)
ANK repeat 65..96 CDD:293786 23/30 (77%)
ANK repeat 98..129 CDD:293786 23/30 (77%)
ANK repeat 131..156 CDD:293786 20/24 (83%)
ANKYR 184..462 CDD:440430 193/277 (70%)
ANK repeat 197..224 CDD:293786 20/26 (77%)
ANK repeat 226..257 CDD:293786 20/30 (67%)
ANK repeat 259..290 CDD:293786 18/30 (60%)
ANK repeat 292..322 CDD:293786 19/29 (66%)
ANK repeat 325..356 CDD:293786 19/30 (63%)
ANKYR 345..627 CDD:440430 183/281 (65%)
ANK repeat 358..389 CDD:293786 22/30 (73%)
ANK repeat 391..422 CDD:293786 25/30 (83%)
ANK repeat 424..455 CDD:293786 19/30 (63%)
ANK repeat 457..488 CDD:293786 18/30 (60%)
ANK repeat 490..519 CDD:293786 17/28 (61%)
ANKYR 505..792 CDD:440430 164/286 (57%)
ANK repeat 523..552 CDD:293786 15/28 (54%)
ANK repeat 556..586 CDD:293786 18/29 (62%)
ANK repeat 589..620 CDD:293786 20/30 (67%)
ANK repeat 622..652 CDD:293786 23/29 (79%)
ANK repeat 655..685 CDD:293786 11/29 (38%)
ANK repeat 688..719 CDD:293786 16/30 (53%)
ANK repeat 721..752 CDD:293786 15/30 (50%)
ANK repeat 754..784 CDD:293786 19/29 (66%)
ZU5 1008..1110 CDD:128514 65/101 (64%)
UPA_2 1337..1472 CDD:375346 68/134 (51%)
Death_ank 1503..1580 CDD:260029 9/90 (10%)
PTZ00449 <1770..2112 CDD:185628 83/427 (19%)

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