DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANK3 and Ank3

DIOPT Version :10

Sequence 1:	NP_066267.2	Gene:	ANK3 / 288	HGNCID:	494	Length:	4377	Species:	Homo sapiens
Sequence 2:	XP_036011414.1	Gene:	Ank3 / 11735	MGIID:	88026	Length:	4691	Species:	Mus musculus

Alignment Length:	4746	Identity:	3879/4746 - (81%)
Similarity:	4078/4746 - (85%)	Gaps:	425/4746 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGV 65
            |||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MAHAASQLKKNRDLEINAEEETEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGV 65

Human    66 DINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNG 130
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 DVNICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNG 130

Human   131 ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195
            ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
Mouse   131 ANVNAQSQNGFTPLYMAAQENHLEVVRFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195

Human   196 DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESK--------SGFTPLHIAAHYGNINVAT 252
            ||||||||||||||||||||||||||||||.|||||||        |||||||||||||||||||
Mouse   196 DTKGKVRLPALHIAARKDDTKAAALLLQNDTNADVESKMVVNRATESGFTPLHIAAHYGNINVAT 260

Human   253 LLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV 317
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 LLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV 325

Human   318 EMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKV 382
            ||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 EMLLDRSAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKV 390

Human   383 AKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN 447
            |||||||||:|||||||||||||||||||||:|||||||||||||||||||||||||||||||||
Mouse   391 AKVLLDKKASPNAKALNGFTPLHIACKKNRIRVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN 455

Human   448 IVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKA 512
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 IVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKA 520

Human   513 DIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGK 577
            ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
Mouse   521 DIVQQLLQQGASPNAATTSGYTPLHLAAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGK 585

Human   578 LEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN 642
            ||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 LEVASLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN 650

Human   643 QMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQE 707
            ||||||:|||||||||||||||||||||||||||||||||||.||||||||||||||||||||||
Mouse   651 QMDIATSLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLSRNANVNLSNKSGLTPLHLAAQE 715

Human   708 DRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQ 772
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||
Mouse   716 DRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTALHQAAQ 780

Human   773 QGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVP 837
            ||||||||||||||||||||||||||||.|||||||||||||||:||||.|||||:|||||||||
Mouse   781 QGHTHIINVLLQNNASPNELTVNGNTALAIARRLGYISVVDTLKVVTEEIMTTTTITEKHKMNVP 845

Human   838 ETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEG------------------EDAMTGDTDKYL 884
            |||||||||||||||||:|||.|||||||||.|||                  |||:||||||||
Mouse   846 ETMNEVLDMSDDEVRKASAPEKLSDGEYISDGEEGDKCTWFKIPKVQEVLVKSEDAITGDTDKYL 910

Human   885 GPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHL 949
            ||||||||||||||||||:||||||||||.: .||||||||||||||||||||||||||||||||
Mouse   911 GPQDLKELGDDSLPAEGYVGFSLGARSASPK-ISSDRSYTLNRSSYARDSMMIEELLVPSKEQHL 974

Human   950 TFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSG-----------FLVSFMVDARGGSMRGSRHH 1003
            ||||||||||||||||||||||||||||||:|||           ||||||||||||||||||||
Mouse   975 TFTREFDSDSLRHYSWAADTLDNVNLVSSPVHSGCSSPLPQYDSRFLVSFMVDARGGSMRGSRHH 1039

Human  1004 GMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFL----------- 1057
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1040 GMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGKLHLPTHPPP 1104

Human  1058 ----------------------GPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDL 1100
                                  |||||||||||||||||||||||||||||||||||||||||||
Mouse  1105 VNEGESLVSRILQLGPQGTKFIGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDL 1169

Human  1101 TELLNGMDEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQAS 1165
            .|||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1170 AELLNGMDEELDSPEELGTKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQAS 1234

Human  1166 FPEGALTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGV 1230
            ||||||||||||||||||||:|.||||||||||||||||||||||||||||||||||||||||||
Mouse  1235 FPEGALTKRIRVGLQAQPVPEETVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGV 1299

Human  1231 SNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETV 1295
            |||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1300 SNGYKGDATPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETV 1364

Human  1296 GLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVL 1360
            |||:||||||||||||||||||||.||||||||||||||||:|||||||||||||||||||||||
Mouse  1365 GLASQLYRELICVPYMAKFVVFAKTNDPVESSLRCFCMTDDRVDKTLEQQENFEEVARSKDIEVL 1429

Human  1361 EGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLP 1425
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1430 EGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLP 1494

Human  1426 QTAVCNLNITLPAHKKETESDQDDEIEKTDRRQSFASLALRKRYSYLTEPGM--IERSTGATRSL 1488
            |||||||||||||||||||||||||.||.|||||||||||||||||||||.|  :|||:|..|||
Mouse  1495 QTAVCNLNITLPAHKKETESDQDDEAEKADRRQSFASLALRKRYSYLTEPSMKTVERSSGTARSL 1559

Human  1489 PTTYSYKPFFSTRPYQSWTTAPITVPGPAKSGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTL 1553
            |||||:||||||||||||||||||||||||||  |||||.|||||||||||||||||||||||||
Mouse  1560 PTTYSHKPFFSTRPYQSWTTAPITVPGPAKSG--SLSSSPSNTPSASPLKSIWSVSTPSPIKSTL 1622

Human  1554 GASTTSSVKSISDVASPIRSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAVTEATPLKGLASNS 1618
            |||||||||||||||||||||||:|||||||||.||||.||:||||.|.|.:|||||:||||.||
Mouse  1623 GASTTSSVKSISDVASPIRSFRTVSSPIKTVVSPSPYNPQVASGTLGRVPTITEATPIKGLAPNS 1687

Human  1619 TFSSRTSPVTTAGSLLERSSITMTPPASPKSNINMYSSSLPFKSIITSAAPLISSPLKSVVSPVK 1683
            |||||||||||||||||||||||||||||||||.|||||||||||||||.|||||||||||||.|
Mouse  1688 TFSSRTSPVTTAGSLLERSSITMTPPASPKSNITMYSSSLPFKSIITSATPLISSPLKSVVSPTK 1752

Human  1684 SAVDVISSAKITMASSLSSPVKQMPGHAEVALVNGSISPLKYPSSSTLINGCKATATLQEKISSA 1748
            ||.||||:||.|||||||||:|||.|||||||||||:|||||||||.||||||||||||:|||:|
Mouse  1753 SAADVISTAKATMASSLSSPLKQMSGHAEVALVNGSVSPLKYPSSSALINGCKATATLQDKISTA 1817

Human  1749 TNSVSSVVSAATDTVEKVFSTTTAMPFSPLRSYVSAAPSAFQSLRTPSASALYTSLGSSISATTS 1813
            ||:||||||||:|||||..|||||||||||||||||||||||||||||||||||||||||:||||
Mouse  1818 TNAVSSVVSAASDTVEKALSTTTAMPFSPLRSYVSAAPSAFQSLRTPSASALYTSLGSSIAATTS 1882

Human  1814 SVTSSIITVPVYSVVNVLPEPALKKLPDSNSFTKSAAALLSPIKTLTTETHPQPHFSRTSSPVKS 1878
            ||||||||||||||||||||||||||||||||||||||||||||||||||.|||||:||||||||
Mouse  1883 SVTSSIITVPVYSVVNVLPEPALKKLPDSNSFTKSAAALLSPIKTLTTETRPQPHFNRTSSPVKS 1947

Human  1879 SLFLAPSALKLSTPSSLSSSQEILKDVAEMKEDLMRMTAILQTDVPEEKPFQPELPKEGRIDDEE 1943
            |||||.||||.|.|||||||||||||||||||||||||||||||||||||||.:||:||||||||
Mouse  1948 SLFLASSALKPSVPSSLSSSQEILKDVAEMKEDLMRMTAILQTDVPEEKPFQTDLPREGRIDDEE 2012

Human  1944 PFKIVEKVKEDLVKVSEILKKDVCVDNKGSPKSPKSDKGHSPEDDWIEFSSEEIREARQQAAASQ 2008
            |||||||||||||||||||||||||::||.||||||||||||||||.||||||||||| |||||.
Mouse  2013 PFKIVEKVKEDLVKVSEILKKDVCVESKGPPKSPKSDKGHSPEDDWTEFSSEEIREAR-QAAASH 2076

Human  2009 SPSLPERVQVKAKAASEKDYNLTKVIDYLTNDIGSSSLTNLKYKFEDAKKDGEERQKRVLKPAIA 2073
            :|||||||..||        |||:||||||||||||||||||||||:|||||||||||:||||:|
Mouse  2077 APSLPERVHGKA--------NLTRVIDYLTNDIGSSSLTNLKYKFEEAKKDGEERQKRILKPAMA 2133

Human  2074 LQEHKLKMPPASMRTSTSEKELCKMADSFFGTDTILESPDDFSQHDQDKSPLSDSGFETRSEKTP 2138
            ||||||||||||||.||||||||||||||||.|.|||||||||||||||||||||||||||||||
Mouse  2134 LQEHKLKMPPASMRPSTSEKELCKMADSFFGADAILESPDDFSQHDQDKSPLSDSGFETRSEKTP 2198

Human  2139 SAPQSAESTGPKPLFHEVPIPPVITETRTEVVHVIRSYDPSAGDVPQTQPEEPVSPKPSPTFMEL 2203
            ||||||||||||||||||||||||||||||||||||||:||:|::||:|||:|||||||||||||
Mouse  2199 SAPQSAESTGPKPLFHEVPIPPVITETRTEVVHVIRSYEPSSGEIPQSQPEDPVSPKPSPTFMEL 2263

Human  2204 EPKPTTSSIKEKVKAFQMKASSEEDDHNRVLSKGMRVKEETHITTTTRMVYHSPPGGEGASERIE 2268
            ||||||||||||||||||||||||:||:||||||||||||||||||||||||||||||.||||||
Mouse  2264 EPKPTTSSIKEKVKAFQMKASSEEEDHSRVLSKGMRVKEETHITTTTRMVYHSPPGGECASERIE 2328

Human  2269 ETMSVHDIMKAFQSGRDPSKELAGLFEHKSAVSPDVHKSAAETSAQHAEKDNQMKPKLERIIEVH 2333
            |||||||||||||||||||||||||||||||:||||.||||||||||||||:|||||||||||||
Mouse  2329 ETMSVHDIMKAFQSGRDPSKELAGLFEHKSAMSPDVAKSAAETSAQHAEKDSQMKPKLERIIEVH 2393

Human  2334 IEKGNQAEPTEVIIRETKKHPEKEMYVYQKDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELT 2398
            ||||||||||||||||||||||||:.|||||||||:|||:||||||||||||.|||||||||||.
Mouse  2394 IEKGNQAEPTEVIIRETKKHPEKEVSVYQKDLSRGNINLRDFLPEKHDAFPCPEEQGQQEEEELA 2458

Human  2399 AEESLPSYLESSRVNTPVSQEEDSRPSSAQLISDDSYKTLKLLSQHSIEYHDDELSELRGESYRF 2463
            |||||||||||||||||.|||||||||||||:|||||||||||||||:||||||||:||||||||
Mouse  2459 AEESLPSYLESSRVNTPGSQEEDSRPSSAQLLSDDSYKTLKLLSQHSVEYHDDELSDLRGESYRF 2523

Human  2464 AEKMLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIYKDVSENGVG 2528
            ||||||||||||||||||||||||||||||||||||||||||:||||.|||||||||||||||:|
Mouse  2524 AEKMLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDKRSREKVATAPPKEILSKIYKDVSENGLG 2588

Human  2529 KVSKDEHFDKVTVLHYSGNVSSPKHAMWMRFTEDRLDRGREKLIYEDRVDRTVKEAEEKLTEVSQ 2593
            :|||||||:|:||||||||||.|||||||..:|||||||||||:|||||||||||||||||||||
Mouse  2589 RVSKDEHFEKLTVLHYSGNVSGPKHAMWMHLSEDRLDRGREKLMYEDRVDRTVKEAEEKLTEVSQ 2653

Human  2594 FFRDKTEKLNDELQSPEKKARPKNGKEYSSQSPTSSSPEKVLLTELLASNDEWVKARQHGPDGQG 2658
            |||||||||||||||||||.||||||:|||||.|||||||| ||||||||||||||||.|||||.
Mouse  2654 FFRDKTEKLNDELQSPEKKPRPKNGKDYSSQSSTSSSPEKV-LTELLASNDEWVKARQRGPDGQS 2717

Human  2659 FPKAEE-KAPSLPSSPEKMVLSQQTEDSKSTVEAKGS-ISQSKAPDGPQSGFQLKQSKLSSIRLK 2721
            .|:||: ||||..:|||..|.:||:||.:...|||.: ::||:..:|||||||||||||||||||
Mouse  2718 VPQAEDRKAPSRSNSPENRVPTQQSEDDQPPEEAKRTVVAQSRGQEGPQSGFQLKQSKLSSIRLK 2782

Human  2722 FEQGTHAKSKDMSQEDRKSDGQSRIPVKKIQESKLPVYQVFAREKQQKAIDLPDESVSVQKDFMV 2786
            ||||..|||||...|::..||.|||||||.||:|||.:..|||||||||:|..:|.|.||.|..|
Mouse  2783 FEQGARAKSKDPPHEEKHLDGPSRIPVKKTQETKLPTHPGFAREKQQKAVDPLEERVPVQNDVTV 2847

Human  2787 LKTKDEHAQSNEIVVNDSGSDNVKKQRTEMSSKAMPDSFSEQQAKDLACHITSDLATRGPWDKKV 2851
            .|.  :||||||||.:.|||.|.|..||||.||||||.|.|||.:|.||.|||||.|:||||:||
Mouse  2848 FKA--DHAQSNEIVTSKSGSGNGKSHRTEMLSKAMPDFFPEQQVEDSACPITSDLETKGPWDRKV 2910

Human  2852 FRTWESSGATNNKSQKEKLSHVLVHDVRENHIGHP-ESKSVDQKNEFMSVTERERKLLTNGSLSE 2915
            |||||||||.|.|:|||:||||||||:||||.|.| :|::.|.|:.||.|||||.|:||||||||
Mouse  2911 FRTWESSGANNTKAQKEQLSHVLVHDIRENHAGRPDDSENGDPKSGFMYVTEREHKMLTNGSLSE 2975

Human  2916 IKEMTVKSPSKKVLYREYVVKEGDHPGGLLDQPSRRSESSAVSHIPVRVADERRMLSSNIPDGFC 2980
            ||||:|||||||||||||:||:||.|...|:.|.||||||..||||:||.|||||||||||||||
Mouse  2976 IKEMSVKSPSKKVLYREYIVKDGDPPSSALNHPPRRSESSLASHIPIRVTDERRMLSSNIPDGFC 3040

Human  2981 EQSAFPKHELSQKLSQSSMSKETVETQHFNSIEDEKVTYSEISKVSKHQSYVGLCPPLEETETSP 3045
            |||.|||.|||.::|:.|||:..||:|||||::||||||||||||||||||:.    |:||||||
Mouse  3041 EQSTFPKQELSPRVSRPSMSEGVVESQHFNSVDDEKVTYSEISKVSKHQSYLA----LDETETSP 3101

Human  3046 TKSPDSLEFSPGKESPSSDVFDHSPIDGLEKLAPLAQTEGGKEIKTLPVYVSFVQVGKQYEKEIQ 3110
            |||||||||||||:|||||||||..:|||||      ||||||||||||||||||||||||||:|
Mouse  3102 TKSPDSLEFSPGKDSPSSDVFDHGSVDGLEK------TEGGKEIKTLPVYVSFVQVGKQYEKELQ 3160

Human  3111 QGGVKKIISQECKTVQETRGTFYTTRQQKQPPSPQGSPEDDTLEQVSFLDSSGKSPLTPETPSSE 3175
            .||||||||||||||||.||||||.||||||||||||||||||||||||||||||||||||||||
Mouse  3161 PGGVKKIISQECKTVQEARGTFYTARQQKQPPSPQGSPEDDTLEQVSFLDSSGKSPLTPETPSSE 3225

Human  3176 EVSYEFTSKTPDSLIAYIPGKPSPIPEVSEESEEEEQAKSTSLKQTTVEETAVEREMPNDVSKDS 3240
            ||||||||||||||||:|||:||||||||||||||| .||..|:|.|     ||:|...||||||
Mouse  3226 EVSYEFTSKTPDSLIAFIPGQPSPIPEVSEESEEEE-PKSAPLRQVT-----VEKETDRDVSKDS 3284

Human  3241 NQRPKNNRVAYIEFPPPPPLDADQIESDKKHHYLPEKEVDMIEVNLQDEHDKYQLAEPVIRVQPP 3305
            .||||.||||||||||||||||||:||||||.||||:||||:||:||||.|||||||||||||||
Mouse  3285 IQRPKCNRVAYIEFPPPPPLDADQMESDKKHQYLPEREVDMMEVSLQDESDKYQLAEPVIRVQPP 3349

Human  3306 SPVPPGADVSDSSDDESIYQPVPVKKYTFKLKEVDDEQKE--KPKASAEKASNQKELESNGSGKD 3368
            |||||||:.||||||||:|||||||||||||||||:.||:  |.|.:|.||||||  |::|:|::
Mouse  3350 SPVPPGAEASDSSDDESLYQPVPVKKYTFKLKEVDEGQKDTAKSKTAATKASNQK--EADGNGRE 3412

Human  3369 NEFGLGLDSPQNEIAQNGNNDQSITECSIATTAEFSHDTDATEIDSLDGYDLQDEDDGLTESDSK 3433
            .|  .||||||||.|||||||||:|||||||||||||||||||||||||||||||||||||||||
Mouse  3413 GE--SGLDSPQNETAQNGNNDQSVTECSIATTAEFSHDTDATEIDSLDGYDLQDEDDGLTESDSK 3475

Human  3434 LPIQAMEIKKDIWNTEGILKPADRSFSQSKLEVI-EEEGKVGPDEDKP-PSKSSSSEKTPDKTDQ 3496
            ||.|.::.|||:| |||||||||||||||||||| |||||||.||:|| ||||.||::||:|.|.
Mouse  3476 LPSQTIDTKKDVW-TEGILKPADRSFSQSKLEVIEEEEGKVGLDEEKPSPSKSPSSDRTPEKADP 3539

Human  3497 KSGAQFFTLEGRHPDRSVFPDTYFSYKVDEEFATPFKTVATKGLDFDPWSNNRGDDEVFDSKSRE 3561
            ||||||||||||||||||.||||||||||||||||||||||||||||||.|||||:||||.||||
Mouse  3540 KSGAQFFTLEGRHPDRSVLPDTYFSYKVDEEFATPFKTVATKGLDFDPWPNNRGDNEVFDGKSRE 3604

Human  3562 DETKPFGLAVEDRSPATTPDTTPARTPTDESTPTSEPNPFPFHEGKMFEMTRSGAIDMSKRDFVE 3626
            |:||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  3605 DDTKPFGLAVDDRSPATTPDTTPARTPTDESTPTSEPNPFPFHEGKMFEMTRSGAIDMSKRDFVE 3669

Human  3627 ERLQFFQIGEHTSEGKSGDQGEGDKSMVTATPQPQSGDTTVETNLERNVETPTVEPNPSIPTSGE 3691
            ||||||||||||.|||||.|||||  |||.|||||||||:|:|||||:|..|:|:||||||::||
Mouse  3670 ERLQFFQIGEHTPEGKSGAQGEGD--MVTDTPQPQSGDTSVDTNLERDVVAPSVDPNPSIPSNGE 3732

Human  3692 CQEGTSSSGSLEKSAAATNTSKVDPKLRTPIKMGISASTMTMKKEGPGEITDKIEAVMTSCQGLE 3756
            |||||:.|||||||||||||||||||.|||||||||||||||||||.||:|||.|||:|||||||
Mouse  3733 CQEGTACSGSLEKSAAATNTSKVDPKSRTPIKMGISASTMTMKKEGSGEVTDKTEAVVTSCQGLE 3797

Human  3757 NETITMISNTANSQMGVRPHEKHDFQKDNFNNNNNLDSSTIQTDNIMSNIVLTEHSAPTCTTEKD 3821
            ||.:..||:..:||:|:||.|||||||||||||||||:||:||||..|:||||..:|.|||||:.
Mouse  3798 NEIVKEISSAPSSQVGIRPQEKHDFQKDNFNNNNNLDASTMQTDNSTSHIVLTGRAASTCTTEEA 3862

Human  3822 NPVKVSSGKKTGVLQGHCVRDKQKVLGEQQKTKELIGIRQKSKLPIKATSPKDTFPPNHMSNTKA 3886
            |||| .|||..|. |||..|:.:         ||.||:|:|||||||||:|||.|||||.:::|.
Mouse  3863 NPVK-GSGKSPGT-QGHSSRESR---------KEPIGLRRKSKLPIKATAPKDVFPPNHKADSKT 3916

Human  3887 SKMKQVSQSEKTKALTTSSCVDVKSRIPVKNTHRDNIIAVRKACATQKQGQPEKGKAKQLPSKLP 3951
            .|.:||.|.||.|||.||||:|.|||||||||||:|:::|||||||||:||||:|||||.|||||
Mouse  3917 GKPRQVGQYEKHKALPTSSCLDAKSRIPVKNTHRENLVSVRKACATQKRGQPERGKAKQPPSKLP 3981

Human  3952 VKVRSTCVTTTTTTATTTTTTTTTTTTSCTVKVRKSQLKEVCKHSIEYFKGISGETLKLVDRLSE 4016
            ||||||.||.|||..:|||||||||||:.||||.:|||||||||.||||||||||||||||||:|
Mouse  3982 VKVRSTRVTVTTTNTSTTTTTTTTTTTTTTVKVTESQLKEVCKHPIEYFKGISGETLKLVDRLTE 4046

Human  4017 EEKKMQSELSDEEESTSRNTSLSETSRGGQPSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRT 4081
            |:|||||||||||||||||||||||||||||||||||||:|||||.|||||..|||     ||||
Mouse  4047 EDKKMQSELSDEEESTSRNTSLSETSRGGQPSVTTKSARNKKTEAPPLKSKRGKAG-----SRRT 4106

Human  4082 GPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDG 4146
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  4107 GPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDG 4171

Human  4147 KNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVD------------- 4198
            ||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  4172 KNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGHPSFQVELETPM 4236

Human  4199 ----------------------------------------------------------------- 4198

Mouse  4237 GLYCTPPNPFQQDDHFSDISSIESPFRTPSRLSDGLVPSQGNIEHPTGGPPVVTAEDTSLEDSKM 4301

Human  4199 ----------------------------------------------------------------- 4198

Mouse  4302 DDSVTVTDPADPLDVDESQLKDLCQSECAQCWASVPGIPNDGRQAEPLRPQTRKVGMSSEQQEKG 4366

Human  4199 -----------------------------------------------------GWQNETSSGNLE 4210
                                                                 ||||||.||:||
Mouse  4367 KSGPDEEVTEDKVKSLFEDIQLEEVEAEEMTEDQGQAMLNRVQRAELAMSSLAGWQNETPSGSLE 4431

Human  4211 SCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHT-EITPEAKTKSYFPESQNDV 4274
            |.|||||:|||||||||||.||.||||||||.||.||.||||:|| |:.||||.|.||||||||:
Mouse  4432 SPAQARRLTGGLLDRLDDSSDQARDSITSYLTGEPGKIEANGNHTAEVIPEAKAKPYFPESQNDI 4496

Human  4275 GKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEET-KPCVPVSMKKMSRTSPADGK 4338
            ||||.||.||||.||.|..|||.|||.||||||||||||:||:. ||||||.||||:||: ||||
Mouse  4497 GKQSIKENLKPKTHGCGRTEEPVSPLTAYQKSLEETSKLVIEDAPKPCVPVGMKKMTRTT-ADGK 4560

Human  4339 PRLSLHEEEGSSGSEQK------------------------------------------------ 4355
            .||:|.|||||:.||.|
Mouse  4561 ARLNLQEEEGSTRSEPKVKSPGEAFTRMTACCYKDLRNSESDSSSEEEQRITTRVIRRRVIIKGE 4625

Human  4356 ---------------------------------------------QGEGFKVKTKKEIRHVEKKS 4375
                                                         ||||:|||||||||:||||:
Mouse  4626 EAKNIPGESVTEEQFTDEEGNLITRKITRKVIRRIGPQERKQDDVQGEGYKVKTKKEIRNVEKKT 4690

Human  4376 H 4376
            |
Mouse  4691 H 4691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANK3	NP_066267.2	ANKYR	1..305	CDD:440430	299/311 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		41/42 (98%)
		ANK repeat	73..104	CDD:293786	30/30 (100%)
		ANK 1	73..102		28/28 (100%)
		ANK repeat	106..137	CDD:293786	30/30 (100%)
		ANK 2	106..135		28/28 (100%)
		ANK 3	139..168		27/28 (96%)
		ANK repeat	139..164	CDD:293786	23/24 (96%)
		ANK 4	172..201		28/28 (100%)
		ANK 5	203..230		25/26 (96%)
		ANK repeat	205..232	CDD:293786	25/26 (96%)
		ANK repeat	234..265	CDD:293786	30/30 (100%)
		ANK 6	234..263		28/28 (100%)
		ANKYR	248..536	CDD:440430	284/287 (99%)
		ANK repeat	267..298	CDD:293786	30/30 (100%)
		ANK 7	267..296		28/28 (100%)
		ANK 8	300..329		27/28 (96%)
		ANK repeat	300..325	CDD:293786	24/24 (100%)
		ANK repeat	333..364	CDD:293786	30/30 (100%)
		ANK 9	333..362		28/28 (100%)
		ANK 10	366..395		27/28 (96%)
		ANK repeat	369..397	CDD:293786	26/27 (96%)
		ANK repeat	399..430	CDD:293786	29/30 (97%)
		ANK 11	399..428		27/28 (96%)
		ANKYR	413..701	CDD:440430	282/287 (98%)
		ANK repeat	432..463	CDD:293786	30/30 (100%)
		ANK 12	432..461		28/28 (100%)
		ANK repeat	465..496	CDD:293786	30/30 (100%)
		ANK 13	465..494		28/28 (100%)
		ANK repeat	498..529	CDD:293786	30/30 (100%)
		ANK 14	498..527		28/28 (100%)
		ANK repeat	531..560	CDD:293786	27/28 (96%)
		ANK 15	531..560		27/28 (96%)
		ANK repeat	564..593	CDD:293786	27/28 (96%)
		ANK 16	564..593		27/28 (96%)
		ANK repeat	597..626	CDD:293786	28/28 (100%)
		ANK 17	597..626		28/28 (100%)
		PHA02875	605..>800	CDD:165206	191/194 (98%)
		ANK repeat	630..660	CDD:293786	28/29 (97%)
		ANK 18	630..659		27/28 (96%)
		ANK repeat	663..694	CDD:293786	29/30 (97%)
		ANK 19	663..692		27/28 (96%)
		ANK repeat	696..727	CDD:293786	30/30 (100%)
		ANK 20	696..725		28/28 (100%)
		ANK repeat	729..760	CDD:293786	30/30 (100%)
		ANK 21	729..758		28/28 (100%)
		ANK 22	762..791		27/28 (96%)
		ANK repeat	762..790	CDD:293786	26/27 (96%)
		ANK 23	795..825		26/29 (90%)
		ZU5	982..1086	CDD:128514	103/147 (70%)
		UPA domain. /evidence=ECO:0000250	1273..1407		130/133 (98%)
		UPA_2	1308..1437	CDD:375346	126/128 (98%)
		Herpes_BLLF1	<1393..1770	CDD:282904	339/378 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1519..1540		17/20 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1968..1987		15/18 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2107..2159		50/51 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2176..2245		60/68 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2299..2322		19/22 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2383..2433		45/49 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2474..2508		32/33 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2588..2751		122/164 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2795..2824		20/28 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3036..3067		26/30 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3131..3272		119/140 (85%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3298..3516		179/221 (81%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3538..3607		63/68 (93%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3635..3718		66/82 (80%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3868..3897		16/28 (57%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4019..4090		61/70 (87%)
Death_ank3	4088..4171	CDD:176781	82/82 (100%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4251..4298		34/47 (72%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4323..4377		41/147 (28%)
Ank3	XP_036011414.1	ANK repeat	473..504	CDD:293786	30/30 (100%)
		ANK repeat	506..537	CDD:293786	30/30 (100%)
		ANK repeat	539..568	CDD:293786	27/28 (96%)
		ANK repeat	572..601	CDD:293786	27/28 (96%)
		ANK repeat	605..634	CDD:293786	28/28 (100%)
		PHA03100	608..>817	CDD:476869	204/208 (98%)
		ANK repeat	638..669	CDD:293786	29/30 (97%)
		ANK repeat	671..702	CDD:293786	29/30 (97%)
		ANK repeat	704..735	CDD:293786	30/30 (100%)
		ANK repeat	737..768	CDD:293786	30/30 (100%)
		ANK repeat	770..798	CDD:293786	26/27 (96%)
		ZU5	1018..1155	CDD:128514	101/136 (74%)
		UPA_2	1377..1506	CDD:375346	126/128 (98%)
		Herpes_BLLF1	<1542..1949	CDD:282904	368/408 (90%)
		Adeno_L433K_22K	3296..>3412	CDD:314108	94/117 (80%)
		Death_ank3	4113..4196	CDD:176781	82/82 (100%)
		ANKYR	1..313	CDD:440430	299/311 (96%)
		ANK repeat	73..104	CDD:293786	30/30 (100%)
		ANK repeat	106..137	CDD:293786	30/30 (100%)
		ANK repeat	139..164	CDD:293786	23/24 (96%)
		ANK repeat	205..240	CDD:293786	28/34 (82%)
		ANK repeat	242..273	CDD:293786	30/30 (100%)
		ANKYR	256..544	CDD:440430	284/287 (99%)
		ANK repeat	275..306	CDD:293786	30/30 (100%)
		ANK repeat	308..333	CDD:293786	24/24 (100%)
		ANK repeat	341..372	CDD:293786	30/30 (100%)
		ANK repeat	377..405	CDD:293786	26/27 (96%)
		ANK repeat	407..438	CDD:293786	29/30 (97%)
		ANKYR	421..709	CDD:440430	282/287 (98%)
		ANK repeat	440..471	CDD:293786	30/30 (100%)

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DRSC/TRiP Functional Genomics Resources

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANK3 and Ank3

DIOPT Version :10

Known Domains:

Indicated by green bases in alignment.