DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANK3 and ank3

DIOPT Version :9

Sequence 1:	NP_066267.2	Gene:	ANK3 / 288	HGNCID:	494	Length:	4377	Species:	Homo sapiens
Sequence 2:	XP_031761145.1	Gene:	ank3 / 100216211	XenbaseID:	XB-GENE-989433	Length:	4361	Species:	Xenopus tropicalis

Alignment Length:	4488	Identity:	3183/4488 - (70%)
Similarity:	3600/4488 - (80%)	Gaps:	238/4488 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGV 65
            ||||||||||||||:|||||:.::|::|||||:|||||||.|||||||||:|:|||||||:||||
Frog     1 MAHAASQLKKNRDLDINAEEDAKEKKRHRKRSKDRKKKSDTNASYLRAARSGNLEKALDYLKNGV 65

Human    66 DINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNG 130
            |||||||||||||||||||||||:||||:||.|:|||:||||||||||||||||.|||:||||||
Frog    66 DINICNQNGLNALHLASKEGHVEIVSELIQRGADVDASTKKGNTALHIASLAGQTEVVRVLVTNG 130

Human   131 ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   131 ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195

Human   196 DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAA 260
            ||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||.||
Frog   196 DTKGKVRLPALHIAARKDDTKAAALLLQNDHNADVESKSGFTPLHIAAHYGNINVATLLLNRGAA 260

Human   261 VDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAA 325
            |||||||||||||||||||||||||||||||:|||||||||||||||||||||||||.|||||.|
Frog   261 VDFTARNDITPLHVASKRGNANMVKLLLDRGSKIDAKTRDGLTPLHCGARSGHEQVVGMLLDRGA 325

Human   326 PILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKK 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   326 PILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKK 390

Human   391 ANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 455
            ||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||.||
Frog   391 ANPNAKALNGFTPLHIACKKNRLKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLNHH 455

Human   456 GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ 520
            ||||||||||||||||||||:||:||||:|:|:|||||||||||||||||||||||||||||||:
Frog   456 GASPNTTNVRGETALHMAARAGQSEVVRFLLQNGAQVEAKAKDDQTPLHISARLGKADIVQQLLK 520

Human   521 QGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL 585
            |||.|:|||||||||||||:||||:|||:.||:||||..|.||||||||||||||||:||..|||
Frog   521 QGAYPDAATTSGYTPLHLSSREGHDDVASVLLEHGASFGIVTKKGFTPLHVAAKYGKIEVVKLLL 585

Human   586 QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 650
            ||:|||||||||||||||||||||||||||||||:|||||.||||||||||||||||||||||||
Frog   586 QKNASPDAAGKSGLTPLHVAAHYDNQKVALLLLDKGASPHGAAKNGYTPLHIAAKKNQMDIATTL 650

Human   651 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEV 715
            |||||||||:|:||||.|||||||||||||||||.|:||||:||||||||||||||||||:||||
Frog   651 LEYGADANAITKQGIAPVHLAAQEGHVDMVSLLLTRSANVNVSNKSGLTPLHLAAQEDRVSVAEV 715

Human   716 LVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIIN 780
            |.||||.:|..|||.||||||..||||||:|.|||||.:||||||||||||||||||||||||||
Frog   716 LANQGAVIDGTTKMFYTPLHVASHYGNIKMVTFLLQHGSKVNAKTKNGYTPLHQAAQQGHTHIIN 780

Human   781 VLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLD 845
            ||||:.|||||:||||||||.|||||||||||||||:|||||:||..||||||||||||||||||
Frog   781 VLLQHGASPNEVTVNGNTALAIARRLGYISVVDTLKVVTEETLTTVLVTEKHKMNVPETMNEVLD 845

Human   846 MSDDEVRKANAPEMLSDGEYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGAR 910
            ||||||.:||.||::||.||:||.:||||||||||||||||||||||||||||.|||.|||:|||
Frog   846 MSDDEVHRANVPEIVSDAEYMSDGDEGEDAMTGDTDKYLGPQDLKELGDDSLPQEGYTGFSIGAR 910

Human   911 SASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNL 975
            |||||||||||||||||||:|||||||||||.|||:|||:.||:|||||||||||||||||||||
Frog   911 SASLRSFSSDRSYTLNRSSFARDSMMIEELLAPSKDQHLSLTRDFDSDSLRHYSWAADTLDNVNL 975

Human   976 VSSPIHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGE 1040
            ||||:||||||||||||||||||||||:||||||||||||||||||||||||||||.||||||||
Frog   976 VSSPVHSGFLVSFMVDARGGSMRGSRHNGMRIIIPPRKCTAPTRITCRLVKRHKLATPPPMVEGE 1040

Human  1041 GLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLN 1105
            |||||||||||:|||||||||||||||||||.||||||||||||||.|||||:|.:.|:||||||
Frog  1041 GLASRLVEMGPSGAQFLGPVIVEIPHFGSMRSKERELIVLRSENGENWKEHQYDCRVEELTELLN 1105

Human  1106 GMDEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGA 1170
            ||||||||.|||.|||||||:||||||||||||||||||||||||||:|.|||||.|||||||||
Frog  1106 GMDEELDSAEELEKKRICRIVTKDFPQYFAVVSRIKQESNQIGPEGGVLKSTTVPRVQASFPEGA 1170

Human  1171 LTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYK 1235
            ||||||||||||||||::|||::||:|||||||||||||||||||||||||:|||||||||||||
Frog  1171 LTKRIRVGLQAQPVPDDLVKKVIGNRATFSPIVTVEPRRRKFHKPITMTIPIPPPSGEGVSNGYK 1235

Human  1236 GDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQ 1300
            |||||:|||||||||||||||||||||||||||:.|||||||||||||||.||||:.|||.||||
Frog  1236 GDTTPSLRLLCSITGGTSPAQWEDITGTTPLTFVNDCVSFTTNVSARFWLGDCHQIPETVSLATQ 1300

Human  1301 LYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPI 1365
            |||||||||||||||||||||||||:.||||||||||||||||||||||||||||||||||||||
Frog  1301 LYRELICVPYMAKFVVFAKMNDPVEARLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPI 1365

Human  1366 YVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVC 1430
            ||||||||||||||||||:||||:|||||||||:|:||.||||||||||||||||||||||||||
Frog  1366 YVDCYGNLAPLTKGGQQLIFNFYAFKENRLPFSVKVRDHSQEPCGRLSFLKEPKTTKGLPQTAVC 1430

Human  1431 NLNITLPAHKKETESDQDDEIEKTDRRQSFASLALRKRYSYLTEPGM--IERSTGATRSLPTTYS 1493
            |||||||..|||||||||||.||.||||:|.||||||||||||||||  ::||.|:||.:|||||
Frog  1431 NLNITLPTQKKETESDQDDENEKVDRRQNFVSLALRKRYSYLTEPGMKPLDRSPGSTRPIPTTYS 1495

Human  1494 YKPFFSTRPYQSWTTAPITVPGPAKSGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTT 1558
            |||.|.||||||||||||||||..|||||||||||||||||||||||||.|:.||||||||||||
Frog  1496 YKPGFPTRPYQSWTTAPITVPGQTKSGFTSLSSSSSNTPSASPLKSIWSGSSASPIKSTLGASTT 1560

Human  1559 SSVKSISDVASPIRSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAVTEATPLKGLASNSTFSSR 1623
            ||:||:||||||||||||::|||||||:||||.||||:|:..||..:.|.|..|||.|:|.|:||
Frog  1561 SSIKSVSDVASPIRSFRTIASPIKTVVTQSPYAIQVSTGSPIRASTIAETTSFKGLPSSSPFASR 1625

Human  1624 TSPVTTAGSLLERSSITMTPPASPKSNINMYSSSLPFKSIITSAAPLISSPLKSVVSPVKSAVDV 1688
            ||||||||||||||||||||||||||||||||||||||||||||..|.||||||||||      .
Frog  1626 TSPVTTAGSLLERSSITMTPPASPKSNINMYSSSLPFKSIITSAGSLSSSPLKSVVSP------A 1684

Human  1689 ISSAKITMASSLSSPVKQMPGHAEVALVNGSISPLKYPSSSTLINGCKATATLQEKISSATNSVS 1753
            :||.|:|||:|||||:|...|.:||.|||||.||||||..|..|||  :...:|:||::.|.|.:
Frog  1685 VSSTKVTMATSLSSPLKLANGPSEVGLVNGSASPLKYPLCSNYING--SAVHIQDKIAAVTKSAT 1747

Human  1754 SVVSAATDTVEKVF--STTTAMPFSPLRSYVSAAPSAFQSLRTPSASALYTSLGSSISATTSSVT 1816
            |.|:|..|.|||.:  |:||.:|:|||||:.|.| |||||:|.|:|||||||..|::::||||||
Frog  1748 STVNATIDAVEKNYSVSSTTPLPYSPLRSFSSTA-SAFQSIRNPAASALYTSFRSTLASTTSSVT 1811

Human  1817 SSIITVPVYSVVNVLPEPALKKLPDSNSFTKSAAALLSPIKTLTTETHPQPHFSRTSSPVKSSLF 1881
            ||.||||||||||||.||.||||.:|.|.|||||||:||.|.|||||..|    .:|:|.|:|||
Frog  1812 SSTITVPVYSVVNVLSEPTLKKLSESASLTKSAAALVSPSKNLTTETPSQ----WSSTPAKTSLF 1872

Human  1882 LAPSALKLSTPSSLSSSQEILKDVAEMKEDLMRMTAILQTDVPEEKPFQPELPKEGRIDDEEPFK 1946
            |||:||||:|.:|||||||||||||:|||||:|||||||||..::|.|.||:.||.||:||||||
Frog  1873 LAPNALKLATTASLSSSQEILKDVADMKEDLIRMTAILQTDTSDDKAFHPEIAKEARIEDEEPFK 1937

Human  1947 IVEKVKEDLVKVSEILKKDVCVDNKGSPKSPKSDKGHSPEDDWIEFSSEEIREARQQAAASQSPS 2011
            :|||||||||||||||||||.::||.|    ....||||||:|:|||:||:.||||.|    :..
Frog  1938 LVEKVKEDLVKVSEILKKDVFLENKLS----TCHAGHSPEDEWVEFSNEELEEARQLA----NTH 1994

Human  2012 LPERVQVKAKAASEKDYNLTKVIDYLTNDIGSSSLTNLKYKFEDAKKDGEERQKRVLKPAIALQE 2076
            .|.:|::|.:..|||||||||||||||||||.::.:.|||:::|.|||||||||||||||:.|||
Frog  1995 APHKVEIKTRTLSEKDYNLTKVIDYLTNDIGGNTFSTLKYRYDDCKKDGEERQKRVLKPAMTLQE 2059

Human  2077 HKLKMPPASMRTSTSEKELCKMADSFFGTDTILESPDDFSQHDQDKSPLSDSGFETRSEKTPSAP 2141
            |||||||:|||.|.|||||||::||.||||..||||||||||:||||||||||||||||||||||
Frog  2060 HKLKMPPSSMRPSASEKELCKLSDSVFGTDMNLESPDDFSQHEQDKSPLSDSGFETRSEKTPSAP 2124

Human  2142 QSAESTGPKPLFHEVPIPPVITETRTEVVHVIRSYDPSAGDVPQTQPEEPVSPKPSPTFMELEPK 2206
            |||||||||||||:|||||||||||||||||||||:|:.||:.:::..|....||...||:|| :
Frog  2125 QSAESTGPKPLFHDVPIPPVITETRTEVVHVIRSYEPTTGDIVESEKGEIPPVKPDAAFMDLE-Q 2188

Human  2207 PTTSSIKEKVKAFQMKASSEEDDHNRVLSKGMRVKEETHITTTTRMVYHSPPGGEGASERIEETM 2271
            ....|:|.|.||||:||..::||...||.|||||||||||||||||||||||..|..|||:||||
Frog  2189 NCPGSMKVKSKAFQIKAGIDDDDPKGVLGKGMRVKEETHITTTTRMVYHSPPVMENKSERLEETM 2253

Human  2272 SVHDIMKAFQSGRDPSKELAGLFEHKSAVSPDVHKSAAETSAQHAEKDNQMKPKLERIIEVHIEK 2336
            ||||||||||||||||||||||||||::|: ||.| ..|||..::|:|.::||||||||||||||
Frog  2254 SVHDIMKAFQSGRDPSKELAGLFEHKTSVT-DVQK-CTETSHPYSERDGKLKPKLERIIEVHIEK 2316

Human  2337 GNQAEPTEVIIRETKKHPEKEMYVYQKDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAEE 2401
            ||||||||||||||||||||||||||:|||:.|.|:||.:.|: ..|||||:.||.|||||||||
Frog  2317 GNQAEPTEVIIRETKKHPEKEMYVYQRDLSQVDYNIKDGITER-SIFPCSEDHGQVEEEELTAEE 2380

Human  2402 SLPSYLESSRVNTPVSQEEDSRPSSAQLISDDSYKTLKLLSQHSIEYHDDELSELRGESYRFAEK 2466
            ||||||||||||||||||||||||||||||||||||||||||||:|||||:||||||||||||||
Frog  2381 SLPSYLESSRVNTPVSQEEDSRPSSAQLISDDSYKTLKLLSQHSVEYHDDDLSELRGESYRFAEK 2445

Human  2467 MLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIYKDVSENGVGKVS 2531
            ||||||:|:||||||||..|||....::||..::.||||:.|.|||:|||||||||||||:||:|
Frog  2446 MLLSEKVDISHSDTEESAADHALLLGTDLQRQERLSREKLITTPKKDILSKIYKDVSENGIGKIS 2510

Human  2532 KDEHFDKVTVLHYSGNVSSPKHAMWMRFTEDRLDRGREKLIYEDRVDRTVKEAEEKLTEVSQFFR 2596
            .|:.|||:|||||:|:..||||||||||||||||||||||:|:||||||||||||||||||||||
Frog  2511 GDDAFDKITVLHYAGDPKSPKHAMWMRFTEDRLDRGREKLLYDDRVDRTVKEAEEKLTEVSQFFR 2575

Human  2597 DKTEKLNDELQSPEKKARPKNGKEYSS-QSPTSSSPEKVLLTELLASNDEWVKARQHGPDGQGFP 2660
            ||||||||||||||||...|..:|:|| .|.|||||||.|.|::..|:|:|.|....|.||:.|.
Frog  2576 DKTEKLNDELQSPEKKPHKKCSREFSSGPSSTSSSPEKTLATDMRTSSDDWTKGHHFGYDGKCFN 2640

Human  2661 KAEE-KAPSLPSSPEKMVLSQQTEDSKSTVEAKGSISQSKAPDGPQSGFQLKQSKLSSIRLKFEQ 2724
            .|:: ||.|||.||||.:..|:.||||...:...|          ||||||||||||||:|||||
Frog  2641 IADDRKATSLPCSPEKRMFEQRVEDSKYGSQQPVS----------QSGFQLKQSKLSSIKLKFEQ 2695

Human  2725 GTHAKSKDMSQEDRKSDGQSRIPVKKIQESKLPVYQVFAREKQQKAIDLPDESVSVQKDFMVLK- 2788
            ..:.|:||..||::|.:..|:|||||.|:.:||.:|..|.:|:||..|      .:..|..:||
Frog  2696 SINLKNKDNVQEEKKQESPSKIPVKKTQDGRLPFFQFHANDKKQKTAD------DINGDMALLKE 2754

Human  2789 -TKDEHAQSNEIVVNDSGSDNVKKQRTEMSSKAMPDSFSEQQA------KDLACHITSDLATRGP 2846
             ..:|..:..|::.|.:...:.|..:..:..:   |.|||||.      ||.|   .|.|..
Frog  2755 SINEECLKFKEMIKNTAVFVDPKIDKAVVGKR---DQFSEQQVSISPSNKDSA---GSSLTL--- 2810

Human  2847 WDKKVFRTWESSGATNNKSQKEKLSHVLVHDVRENHIGHPESKSVDQKNEFMSVTE--RERKLLT 2909
             |||.:||||:....|||:.||.|:||.|           ::|..:..:...::.|  :|:.|..
Frog  2811 -DKKHYRTWEAPVINNNKTAKENLTHVFV-----------QNKEAENSSSHAAILELNKEQFLPK 2863

Human  2910 NGSLSEIKEMTVKSPSKKVLYREYVVKE----GDHPGGLLDQPSRRSESSAVSHIPVRVADERRM 2970
            |||.|. :...||||||||||.:...|:    .|...|      .:.|...:|||||||.:|::
Frog  2864 NGSDSR-ESNYVKSPSKKVLYTDLARKDRAFTSDEKNG------HKKEGGCISHIPVRVTEEKK- 2920

Human  2971 LSSNIPDGFCEQSAFPKHELS-QKLSQSSMSKET-VETQHFNSIEDEKVTYSEISKVSKHQSYVG 3033
             ||:..|.   |::..|.|.. .|.....|.::: .||.|...:.||....|:| .:.|.|.::|
Frog  2921 -SSHSSDA---QTSLTKVETEWTKAPTIPMFRQSKPETLHCAFVTDESNRRSDI-HLPKTQDHLG 2980

Human  3034 LCPPLEETETSPTKSPDSLEFSPGKESPSSDVFDHSPIDGLEKLAPLAQTEGGKEIKTLPVYVSF 3098
            |.|..|::|.||.||||||||||.|||.:: :.:....|.|.:...:|.||..|||||||||||.
Frog  2981 LSPSNEDSEISPVKSPDSLEFSPVKESTTA-LANQIKADDLNRKISVAGTEVLKEIKTLPVYVSI 3044

Human  3099 VQVGKQYEKEIQQGGVKKIISQECKTVQETRGTFYTTRQQKQPPSPQGSPEDDTLEQVSFLDSSG 3163
            ||||||.|||:|||.||||:|||.:||||.|||.:..:.|||||||||||||||||||||:||||
Frog  3045 VQVGKQVEKEVQQGSVKKIVSQESRTVQEARGTLFAIKPQKQPPSPQGSPEDDTLEQVSFIDSSG 3109

Human  3164 KSPLTPETPSSEEVSYEFTSKTPDSLIAYIPGKPSPIPEVSEESEEEEQAKSTSLKQTTVEETAV 3228
            |||:||||||||||||||.|||||||:.||||||||||||||||||||..|..|:||........
Frog  3110 KSPMTPETPSSEEVSYEFNSKTPDSLMPYIPGKPSPIPEVSEESEEEELTKLPSVKQVIPGSPPT 3174

Human  3229 EREMPNDVSKDSNQRPKNNRVAYIEFPPPPPLDADQIESDKKHHYLPEKEVDMIEVNLQDEHDKY 3293
            :...|.::||::|:|.|:|||||||||||||||::..:|.||:....:.|::|.||||||:||||
Frog  3175 DIPHPINISKEANKRVKDNRVAYIEFPPPPPLDSELSDSSKKNDNSTDSEMEMTEVNLQDDHDKY 3239

Human  3294 QLAEPVIRVQPPSPVPPGADVSDSSDDESIYQPVPVKKYTFKLKEVDDEQKEKPKASAEKASNQK 3358
            ..||||||||||||||...:.||||||||:.||..|||||||:|  |:|.||..|.:....|:.|
Frog  3240 LSAEPVIRVQPPSPVPLEFEASDSSDDESVLQPFAVKKYTFKIK--DEEIKECVKINTSGKSSAK 3302

Human  3359 ELESNGSGKDNEFGLGLDSPQNEIAQNGN-NDQSITECSIATTAEFSHDTDATEIDSLDGYDLQD 3422
            :        ..:...||:||.|::.|||| ||||:||||||||||||||||||||||||||||||
Frog  3303 Q--------SQDLDEGLNSPSNDVEQNGNGNDQSVTECSIATTAEFSHDTDATEIDSLDGYDLQD 3359

Human  3423 EDDGLTESDSKLPI-QAMEIKKDIWNTEGILKPADRSFSQSKLEVIEEEGKVGPDEDKPPSKSSS 3486
            ||||||||||||.: |..::||:.|..||:||..||||||||||||||| ||..:|.||..|.|.
Frog  3360 EDDGLTESDSKLTLSQDNDMKKEPWAKEGVLKHTDRSFSQSKLEVIEEE-KVVTEEYKPCRKVSD 3423

Human  3487 SE-KTPDKTDQKSGAQFFTLEGRHPDRSVFPDTYFSYKVDEEFATPFKTVATKGLDFDPWSNNRG 3550
            || |..::.|:|.|.||||||||||||.:||||||||||||||||||||||||.|||||||:..|
Frog  3424 SEIKKNEQGDKKPGVQFFTLEGRHPDRPIFPDTYFSYKVDEEFATPFKTVATKSLDFDPWSSKAG 3488

Human  3551 DDEVFDSKSREDETKPFGLAVEDRSPATTPDTTPARTPTDESTPTSEPNPFPFHEGKMFEMTRSG 3615
            ||:||::||::::.|||.|||||||.|||||||||||||||||||||||||||||||||||||||
Frog  3489 DDDVFETKSKDEDPKPFSLAVEDRSQATTPDTTPARTPTDESTPTSEPNPFPFHEGKMFEMTRSG 3553

Human  3616 AIDMSKRDFVEERLQFFQIGEHTSEGKSGDQGEGDKSMVTATPQPQSGDTTVETNLERNVETPTV 3680
            ||||||||||||||||||||||.|||||||:|||||  :||...|||||..||..:|:.|||..|
Frog  3554 AIDMSKRDFVEERLQFFQIGEHNSEGKSGDKGEGDK--ITAITLPQSGDILVEPIIEKQVETSAV 3616

Human  3681 EPNPSIPTSGECQEGTSSSGSLEKSAAATNTSKVDPKLRTPIKMGISASTMTMKKEGPGEITDKI 3745
            |....|.:||||.:||:.:.|||||:||| |||.|||||||||||||||||:.||:|.||:.||:
Frog  3617 EHTSVIQSSGECLDGTNGNNSLEKSSAAT-TSKADPKLRTPIKMGISASTMSTKKDGTGEVADKV 3680

Human  3746 EAVMTSCQGLENETITMISNTANSQMGVRPHEKHDFQKDNFNNNNNLDSSTIQTDNIMS-NIVLT 3809
            |||    ..|:|:....::..::|...:...|.||||.:|:|||||||.|.|..:|..: |:||:
Frog  3681 EAV----SDLDNDNKISLTKLSSSDTFISQIEIHDFQAENYNNNNNLDFSAINVNNNNTINLVLS 3741

Human  3810 EHSAPTCTTEKDNPVKVSSGKKTGVLQGHCVRDKQKVLGEQQKTKELIGIRQKSKLPIKATSPKD 3874
            : .|.|....|.|.:|::.||:.|....|..|||:|:...:|||.:||..|.:||||:||..|..
Frog  3742 K-EADTKPEMKGNKIKLNIGKEVGSSDHHGDRDKKKLQKGEQKTTDLITNRPRSKLPVKAVRPVS 3805

Human  3875 TFPPNHMS--NTKASKMKQVSQSEKTKALTTSSCVDVKSRIPVKNTHRDNIIAVRKACATQKQGQ 3937
                |.:|  ||.:.:.|..|:.||.......:..|:||:|||||.:|.|....:.....|||.|
Frog  3806 ----NQVSHTNTISGRKKLPSKGEKCTKQEFITNADIKSKIPVKNLNRVNPPVQKYVTPKQKQAQ 3866

Human  3938 PEKGKAKQLPSKLPVKVRSTCVTTTTTTATTTTTTTTTTTTSCTVKVRKSQLKEVCKHSIEYFKG 4002
            .||..|||.||||||||||....|:                  |.||:|.:..||||||||||||
Frog  3867 LEKEAAKQAPSKLPVKVRSAPNATS------------------TAKVKKYEFSEVCKHSIEYFKG 3913

Human  4003 ISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSLSETSRGGQPSVTTKSARDKKTEAAPLKSK 4067
            |||||||||||||||||....|.||||:|||||||:||.::..|||||::||::.|.:|||||||
Frog  3914 ISGETLKLVDRLSEEEKNAHREGSDEEDSTSRNTSVSEATQVSQPSVTSRSAKEMKADAAPLKSK 3978

Human  4068 SEKAGSEKRSSRRTGPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLIS 4132
            .||...|:||:||||||||||||||||||||||||||||||||||||||||||||||||||||.:
Frog  3979 IEKTDRERRSNRRTGPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLTA 4043

Human  4133 QSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDP- 4196
            ||||||||||.||||||||||||:||||||||||||||||||||||||||||||||: |:|.||
Frog  4044 QSFMLLKKWVVRDGKNATTDALTNVLTKINRIDIVTLLEGPIFDYGNISGTRSFADD-NIFLDPA 4107

Human  4197 VDGWQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPEA 4261
            ||||.||.||..:|.....|::...||:|||||    .:|||||||||.|:.|:|.|.:|...|.
Frog  4108 VDGWPNEASSMLVEPPTPDRKLNSELLERLDDS----HESITSYLKGEVGRLESNVSPSESITEG 4168

Human  4262 KTKSYFPESQNDVGKQSTKETLKPK-IHGSGHVEEPASPLAAYQKSLEETSKLIIEETKPCVPVS 4325
            ||:|..||:.|.  |.:.|:.:||| :.|.|   |..||...:|||.|.|||.:|.|.|..:|:|
Frog  4169 KTRSTAPETDNI--KTNEKQCMKPKTLQGKG---EQTSPTTVHQKSHEVTSKAVIGEHKSSLPIS 4228

Human  4326 MKKMS--------------------------------RTSPADGKPRLSLH-------------- 4344
            .|:||                                ..|.:|...|::..
Frog  4229 AKRMSGHTEEGSSSDQKSAGKTCLKCIYQASSDSEYESVSSSDEAERITTKVTRRRLILKGEQAK 4293

Human  4345 -------------EEEG----------------------SSGSEQKQGEGFKVKTKKEIRHVEKK 4374
                         :|||                      |||.|....|.:|||||||:||:|||
Frog  4294 NIPGESVTEEQYTDEEGNIITRKVTRKVLKRIVVSHEKKSSGRETVGTEAYKVKTKKEVRHIEKK 4358

Human  4375 SHS 4377
            |:|
Frog  4359 SYS 4361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANK3	NP_066267.2	ANK 6	234..263		27/28 (96%)
		ANK repeat	267..298	CDD:293786	29/30 (97%)
		ANK 7	267..296		27/28 (96%)
		Ank_2	272..363	CDD:289560	87/90 (97%)
		ANK	295..420	CDD:238125	121/124 (98%)
		ANK 8	300..329		26/28 (93%)
		ANK repeat	300..325	CDD:293786	23/24 (96%)
		ANK repeat	333..364	CDD:293786	30/30 (100%)
		ANK 9	333..362		28/28 (100%)
		ANK	361..486	CDD:238125	119/124 (96%)
		ANK 10	366..395		28/28 (100%)
		ANK repeat	369..397	CDD:293786	27/27 (100%)
		Ank_2	371..463	CDD:289560	89/91 (98%)
		ANK repeat	399..430	CDD:293786	29/30 (97%)
		ANK 11	399..428		27/28 (96%)
		ANK repeat	432..463	CDD:293786	29/30 (97%)
		ANK 12	432..461		27/28 (96%)
		ANK	460..585	CDD:238125	105/124 (85%)
		ANK repeat	465..496	CDD:293786	25/30 (83%)
		ANK 13	465..494		23/28 (82%)
		Ank_2	470..561	CDD:289560	75/90 (83%)
		ANK repeat	498..529	CDD:293786	27/30 (90%)
		ANK 14	498..527		26/28 (93%)
		ANK repeat	531..560	CDD:293786	22/28 (79%)
		ANK 15	531..560		22/28 (79%)
		Ank_2	536..626	CDD:289560	76/89 (85%)
		ANK	560..684	CDD:238125	113/123 (92%)
		ANK repeat	564..593	CDD:293786	24/28 (86%)
		ANK 16	564..593		24/28 (86%)
		ANK repeat	597..626	CDD:293786	27/28 (96%)
		ANK 17	597..626		27/28 (96%)
		ANK repeat	630..660	CDD:293786	29/29 (100%)
		ANK 18	630..659		28/28 (100%)
		Ank_4	631..684	CDD:290365	49/52 (94%)
		ANK	658..783	CDD:238125	105/124 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		33/42 (79%)
		Ank_4	47..94	CDD:290365	42/46 (91%)
		ANK	68..193	CDD:238125	117/124 (94%)
		ANK repeat	73..104	CDD:293786	26/30 (87%)
		ANK 1	73..102		24/28 (86%)
		Ank_2	78..164	CDD:289560	78/85 (92%)
		ANK repeat	106..137	CDD:293786	28/30 (93%)
		ANK 2	106..135		26/28 (93%)
		ANK 3	139..168		28/28 (100%)
		ANK repeat	139..164	CDD:293786	24/24 (100%)
		Ank_4	140..193	CDD:290365	52/52 (100%)
		ANK 4	172..201		28/28 (100%)
		ANK 5	203..230		25/26 (96%)
		ANK repeat	205..232	CDD:293786	25/26 (96%)
		Ank_2	206..297	CDD:289560	87/90 (97%)
		ANK	229..354	CDD:238125	120/124 (97%)
		ANK repeat	234..265	CDD:293786	29/30 (97%)
		ANK repeat	663..694	CDD:293786	26/30 (87%)
		ANK 19	663..692		25/28 (89%)
		Ank_2	669..759	CDD:289560	73/89 (82%)
		ANK repeat	696..727	CDD:293786	25/30 (83%)
		ANK 20	696..725		24/28 (86%)
		ANK repeat	729..760	CDD:293786	23/30 (77%)
		ANK 21	729..758		21/28 (75%)
		Ank_5	749..803	CDD:290568	47/53 (89%)
		ANK 22	762..791		26/28 (93%)
		ANK repeat	762..790	CDD:293786	25/27 (93%)
		ANK 23	795..825		26/29 (90%)
		ZU5	982..1086	CDD:128514	99/103 (96%)
UPA domain. /evidence=ECO:0000250	1273..1407		122/133 (92%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1519..1540		20/20 (100%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1968..1987		7/18 (39%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2107..2159		47/51 (92%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2176..2245		32/68 (47%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2299..2322		9/22 (41%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2383..2433		46/49 (94%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2474..2508		18/33 (55%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2588..2751		93/164 (57%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2795..2824		3/28 (11%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3036..3067		18/30 (60%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3131..3272		98/140 (70%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3298..3516		140/220 (64%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3538..3607		54/68 (79%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3635..3718		50/82 (61%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3868..3897		9/30 (30%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4019..4090		45/70 (64%)
Death_ank3	4088..4171	CDD:176781	78/82 (95%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4251..4298		18/47 (38%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4323..4377		29/134 (22%)
ank3	XP_031761145.1	PHA03095	39..>305	CDD:222980	251/265 (95%)
		ANK repeat	73..104	CDD:293786	26/30 (87%)
		ANK repeat	106..137	CDD:293786	28/30 (93%)
		ANK repeat	139..164	CDD:293786	24/24 (100%)
		ANK repeat	205..232	CDD:293786	25/26 (96%)
		ANK repeat	234..265	CDD:293786	29/30 (97%)
		PHA03095	248..>553	CDD:222980	286/304 (94%)
		ANK repeat	267..298	CDD:293786	29/30 (97%)
		ANK repeat	300..325	CDD:293786	23/24 (96%)
		ANK repeat	333..364	CDD:293786	30/30 (100%)
		ANK repeat	366..397	CDD:293786	30/30 (100%)
		ANK repeat	399..430	CDD:293786	29/30 (97%)
		ANK repeat	432..463	CDD:293786	29/30 (97%)
		ANK repeat	465..495	CDD:293786	24/29 (83%)
		ANK repeat	498..527	CDD:293786	26/28 (93%)
		ANK repeat	531..556	CDD:293786	19/24 (79%)
		Ank_2	563..>788	CDD:423045	197/224 (88%)
		ANK repeat	565..595	CDD:293786	25/29 (86%)
		ANK repeat	597..628	CDD:293786	28/30 (93%)
		ANK repeat	630..659	CDD:293786	28/28 (100%)
		ANK repeat	663..694	CDD:293786	26/30 (87%)
		ANK repeat	696..727	CDD:293786	25/30 (83%)
		ANK repeat	729..760	CDD:293786	23/30 (77%)
		ANK repeat	762..790	CDD:293786	25/27 (93%)
		Ank_4	763..815	CDD:372654	47/51 (92%)
		ZU5	982..1086	CDD:128514	99/103 (96%)
		UPA_2	1308..1437	CDD:375346	121/128 (95%)
		Herpes_BLLF1	<1543..>1921	CDD:282904	268/390 (69%)
		SP1-4_N	<2973..>3147	CDD:425404	121/174 (70%)
		Death_ank3	3999..4082	CDD:176781	78/82 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	2971	1.000	Domainoid score	I29
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56908
Inparanoid	1	1.050	5827	1.000	Inparanoid score	I44
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1011028at2759
OrthoFinder	1	1.000	-	-		FOG0000917
OrthoInspector	1	1.000	-	-		oto151409
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1361
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060