DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GPS2 and CG17002

DIOPT Version :9

Sequence 1:NP_004480.1 Gene:GPS2 / 2874 HGNCID:4550 Length:327 Species:Homo sapiens
Sequence 2:NP_610253.1 Gene:CG17002 / 35610 FlyBaseID:FBgn0033122 Length:421 Species:Drosophila melanogaster


Alignment Length:424 Identity:103/424 - (24%)
Similarity:161/424 - (37%) Gaps:146/424 - (34%)


- Green bases have known domain annotations that are detailed below.


Human    11 SNAMAR------------ALHRHIMMERERKRQEEEEVDKMMEQKMKEEQERRKKKEME--ERMS 61
            |||.|:            ||...|:.:|:| ||||      .|.:.:|::.||:::|:|  .:::
  Fly    10 SNAAAQAAKAERAEKLRGALKGFIVADRQR-RQEE------FEAQCEEQRLRREREEVERQNQVA 67

Human    62 LEETKEQILKLEEKLLALQEEKHQLFLQLKKVLHEEEKRRR-KEQSDLTTLTSAAYQQSLTV--- 122
            |::|:.||.:|:|:|..|..:||||.:||||||:|:|.|:: .::::|..:..||....:.:   
  Fly    68 LDDTRGQITRLDEQLADLHSQKHQLTVQLKKVLNEDETRKKLAKENELFAIQQAAASSPVFLPPL 132

Human   123 ------HTGTHLLSMQGSPGGHNRPGTLMAADRAKQMFGPQVLTTRHYVGSAAAFAGTPEH---- 177
                  ||....|...|.||...|..:..:..:|             |..|||::| ..:|    
  Fly   133 RLQHQHHTLMQKLPSGGQPGKRGRSPSPPSQQQA-------------YYKSAASYA-QQKHDDYR 183

Human   178 --------------GQFQGSPGGAYGTAQPPP--------------HYG-PTQPAYS---PSQQL 210
                          .|:.|:....|.|..|||              :|. |.:.||.   ||..:
  Fly   184 RAADYARLSWNKTAAQYPGTGTVFYQTVAPPPTTQHQADARLQSIYNYNLPLRQAYHVDLPSATV 248

Human   211 RAPSAFPAVQYLSQPQPQPYAVHGHFQPT--QTGFL-QPGGALSLQKQMEHANQQTGFSDSSSLR 272
            ..|....:.:..||.||.........|||  |...: |.||:||::....|...:. ..|...:.
  Fly   249 SKPPDSQSPKAPSQSQPMQVLHINLDQPTISQADLVAQAGGSLSVKASQPHVTMEK-LPDRYHIE 312

Human   273 PMH----PQALHPAPGLL----------------------ASPQLPVQM---------------- 295
            ..|    |..:.|.|.||                      :|.|.|.|.                
  Fly   313 VKHDGQPPSHVPPPPHLLPEGVIFKPLLNELSLHSNVLQISSSQFPPQNPKTAGSITQGYAPGRG 377

Human   296 ------------------QPAGKSGFAATSQPGP 311
                              ||...|| :.::||.|
  Fly   378 GSAHEQQLARQQLAMLPGQPGAPSG-SGSAQPPP 410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GPS2NP_004480.1 G_path_suppress 5..292 CDD:406402 94/369 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..65 13/40 (33%)
interaction with SUMO. /evidence=ECO:0000269|PubMed:20159957 61..94 16/32 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 177..208 13/66 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..327 19/119 (16%)
CG17002NP_610253.1 G_path_suppress 23..271 CDD:292610 71/268 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141963
Domainoid 1 1.000 72 1.000 Domainoid score I9372
eggNOG 1 0.900 - - E1_298IM
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 78 1.000 Inparanoid score I5252
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR22654
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5091
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.920

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