DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf145 and rnf145a

DIOPT Version :9

Sequence 1:	NP_001099248.1	Gene:	Rnf145 / 287212	RGDID:	1309561	Length:	664	Species:	Rattus norvegicus
Sequence 2:	XP_005157379.1	Gene:	rnf145a / 565986	ZFINID:	ZDB-GENE-111012-3	Length:	649	Species:	Danio rerio

Alignment Length:	640	Identity:	537/640 - (83%)
Similarity:	581/640 - (90%)	Gaps:	9/640 - (1%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MAAKEKLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLSNNPLFQYKYLALNMHYVGYIL 65
            ||.||::||||||.|||||||||:||||||||||||:||||||:||||||||||||.:|||||||
Zfish     1 MAVKERVEAVLNVGLRVPSIMLLEVLYRWDVSSFFQKIQRSSLNNNPLFQYKYLALYLHYVGYIL 65

  Rat    66 SVVLLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVRSELESAYEGPMYLEPLSMNRFTTALIGQ 130
            |:||||||||||||||||.||||||:||||||||||||||||.||||:||||||:|||||||:.|
Zfish    66 SLVLLTLPRQHLVQLYLYVLTALLLFAGHQISRDYVRSELESGYEGPLYLEPLSINRFTTALLCQ 130

  Rat   131 LVVCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPY 195
            |||||||||||:||:|||||||:|||:||||||||||||.:|:||||||||||:|||.||||||:
Zfish   131 LVVCTLCSCVMQTKRIWLFSAHLLPLVARLCLVPLETIVFVNRFAMIFTGLEVIYFLASNLLVPF 195

  Rat   196 NLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLL 260
            ||||:|||||.||||||||||||||||||||:|||||.|||||||||||:||||||||.||||||
Zfish   196 NLAKTAYRELAQVVEVYGLLALGMSLWNQLVLPVLFMCFWLVLFALQIYTYFSTRDQPTSRERLL 260

  Rat   261 FLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILA 325
            |||||||||||.||||||||||||||||||||||||||||||||||||..|:||||||:||||||
Zfish   261 FLFLTSIAECCCTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDNTMHRGMTEGITLLILA 325

  Rat   326 VQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLL 390
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   326 VQTGLIELQVIHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLL 390

  Rat   391 VFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVN 455
            ||||||:|||||||||||||||||||||||||||||||.|||||||||.||.||||||||||:||
Zfish   391 VFPAYMSYMICQFFHMDFWLLIIISSSILTSLQVLGTLLIYVLFMVEELRKAPVENMDDVIYWVN 455

  Rat   456 GTYRLLEFLVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIK 520
            ||||||||||||||||||||||:|||||||||.|:.|||||||||||||||:|||||||||||||
Zfish   456 GTYRLLEFLVALCVVAYGVSETVFGEWTVMGSTIVLIHSYYNVWLRAQLGWQSFLLRRDAVNKIK 520

  Rat   521 SLPIATKEQLERHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQDTCPLCHCHLKNSSQLP 585
            |||.|:.:||::|||||:||||||.|||||||||.|||||||||||||:||||||..||.||||.
Zfish   521 SLPTASLQQLQQHNDICSICYQDMTSAVITPCSHLFHAGCLKKWLYVQETCPLCHNQLKGSSQLG 585

  Rat   586 GLGTEPAPQPPVAGAEQNIVLQEGPEPPDHETPPGPGAQEGSGDNSEYINRSSAS 640
            ....:..||...|..|::   |:..||.|.|:    ..|:...|:|.  .|:.||
Zfish   586 SSSQDVPPQDTPAQPEED---QDPSEPADSES----NLQDLRQDDSS--TRAPAS 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf145	NP_001099248.1	TRC8_N	8..506	CDD:404574	452/497 (91%)
		HRD1	<520..643	CDD:227568	67/121 (55%)
		RING-H2_RNF145	533..575	CDD:319598	37/41 (90%)
rnf145a	XP_005157379.1	TRC8_N	8..506	CDD:290425	452/497 (91%)
rnf145a	XP_005157379.1	zf-RING_2	535..575	CDD:290367	35/39 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194903077
Domainoid	1	1.000	915	1.000	Domainoid score	I492
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1067	1.000	Inparanoid score	I1886
OMA	1	1.010	-	-		QHG46488
OrthoDB	1	1.010	-	-		D119734at7742
OrthoFinder	1	1.000	-	-		FOG0006288
OrthoInspector	1	1.000	-	-		otm32409
orthoMCL	1	0.900	-	-		OOG6_109881
Panther	1	1.100	-	-	LDO	PTHR22763
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4575
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770