DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf145 and Trc8

DIOPT Version :9

Sequence 1:	NP_001099248.1	Gene:	Rnf145 / 287212	RGDID:	1309561	Length:	664	Species:	Rattus norvegicus
Sequence 2:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster

Alignment Length:	793	Identity:	210/793 - (26%)
Similarity:	351/793 - (44%)	Gaps:	195/793 - (24%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MAAKEKLEAVLNVALRVPSIMLLDVLYRWDV---------------------------------- 31
            |:.:.|:..:::|.:|||.:|::|.:.:.|:
  Fly     1 MSVRTKVLGLVDVMMRVPPVMVIDEILKMDMGMQSWLYPDKDKASGALATPTEAPAVPSGQDPFT 65

  Rat    32 --------------SSFFQQIQRSS--------LSN------NPLFQYKYLA--LNMHYVGYILS 66
                          |...|.|:::|        ||:      |.|.:.:.||  |:...|.::|.
  Fly    66 SIKELFSHMTTSAQSVLEQSIEKASEAAKTHGMLSSGFNSLMNELSKDQTLADVLSTTTVKFVLC 130

  Rat    67 V-------VLLTLPRQHLVQLYLYFLTAL----LLYAGHQISRDYVRSELESAYEGPMYLEPL-S 119
            |       .:..|..:|||.:|: |||:|    |.|..:.       |.|......|..:|.| |
  Fly   131 VFAFLSAACIFMLWTRHLVMVYM-FLTSLGLTFLSYWSNV-------SALALTERSPSMVEDLMS 187

  Rat   120 MNRFTTALIGQ-LVVCTLCSCVMKTKQIWLFSAH-------------------------MLPLLA 158
            :|  ||.|:.. .||.:|...:|....:.:..|:                         ||||.|
  Fly   188 LN--TTRLLDSGGVVMSLAPHLMAQWFMGMLFAYIHLGPRFEHVQRSMPIIFASPILLAMLPLPA 250

  Rat   159 R----LCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGM 219
            :    |.:|.:.|.:|:.|..::.:.:|....:       ||    .|:..:..|..:||.||..
  Fly   251 KVVQHLPVVAVFTPIILTKITLMQSAMEASRTV-------YN----GYQYAMNFVSNFGLSALIE 304

  Rat   220 SLWNQLVVPVLFMVFWLVLFALQIYSYFSTR-DQP----ASRERLLFLFLTSIAECCSTPYSLLG 279
            :.|.:|.||.:..|||.:......|:..:|. |:|    .:.::||       .:.|.|..::||
  Fly   305 NEWQRLNVPNVLRVFWTIRLIQGGYALATTESDEPLDLMTATQKLL-------VDGCETMTAVLG 362

  Rat   280 LVFTVSFVALGVLTL-CKFYLQGYRAFM---NDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAF 340
            :.        ||::: |.:..:|::.::   :|...:.|....|...|||:||||..|....|..
  Fly   363 MT--------GVISMFCHYIGRGFQWYLLTYDDEEKSLGTVSAVLFYILALQTGLTSLSPDKRFI 419

  Rat   341 LLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFH 405
            .|...|.:::.::|..:..|..||:::|.|:|:.|..:|.||:|:|.||:|....:.|.:.....
  Fly   420 RLCRNLCLLMTALLHFLHNIVSPILMSLSAARNPSRKRHVRALSVCAFLVVLSVSLLYHLWSQQS 484

  Rat   406 MDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFLVALCVV 470
            :..|||.:.:.|:...::||.:|..|.||:::..|:...|.:||.:|||......:||
  Fly   485 ISTWLLAVTAFSVEVVVKVLVSLATYTLFLLDARRQFFWEKLDDYLYYVRAFGNSVEF------- 542

  Rat   471 AYGVSETIFGEWTV------------MGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLP 523
            .:|:...|.|.|.:            :.::::.||:|:|:|..|:.||..|:.||.||:||.:||
  Fly   543 CFGILLFINGAWILIFESAQNATGGGIRAIMMCIHAYFNIWCEARAGWSVFMKRRSAVHKISALP 607

  Rat   524 IATKEQLERHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQDTCPLCHCHLKNSSQLPGLG 588
            .||..||:..:|:||||||:|.||.||.|.||||..||:|||||||.|||||..:..:.:    .
  Fly   608 EATPAQLQAFDDVCAICYQEMYSAKITRCRHFFHGVCLRKWLYVQDRCPLCHEIMMYTDK----A 668

  Rat   589 TEPAPQ---PPVAGAEQNIVL----------------QEGPEPPDHETPPGPGAQEGSGDNSEYI 634
            .|.||:   .|.|.|||.:.:                :..|.....:.|....:...:...:|.:
  Fly   669 DENAPEAEPAPAAQAEQPMRIYPRDDANNAAAQRRSPERAPVEASEQAPATSSSSAAATIGAEAV 733

  Rat   635 NR--SSASREGDA 645
            :.  .||:..|:|
  Fly   734 SAIVESAAAVGEA 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf145	NP_001099248.1	TRC8_N	8..506	CDD:404574	147/624 (24%)
		HRD1	<520..643	CDD:227568	50/143 (35%)
		RING-H2_RNF145	533..575	CDD:319598	29/41 (71%)
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425	129/510 (25%)
		zf-rbx1	<618..659	CDD:289448	29/40 (73%)
		zf-RING_2	619..659	CDD:290367	29/39 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9055
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302551at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.780