Protein Alignment GRK6 and grk6

DIOPT Version :10

• Sequence 1: NP_002073.2
• Gene: GRK6 / 2870
• HGNCID: 4545
• Length: 589
• Species: Homo sapiens
• Sequence 2: XP_689783.3
• Gene: grk6 / 561288
• ZFINID: ZDB-GENE-101006-5
• Length: 575
• Species: Danio rerio
• Alignment Length: 559
• Identity: 469/559 - (83%)
• Similarity: 507/559 - (90%)
• Gaps: 0/559 - (0%)

Human     1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRL 65
            ||||||||||||||||||||||||||||||:|||||||||.|||||.::|:||:|||||||||||
Zfish     1 MELENIVANTVLLKAREGGGGNRKGKSKKWKQMLQFPHISLCEELRQTIEKDYNSLCERQPIGRL 65

Human    66 LFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEVPRQLVTNCT 130
            |||:||.|||||.|||.|||.|||||||||:|||.||::|...:|:....|.||||..::||.|.
Zfish    66 LFRQFCDTRPELRRCVRFLDAVAEYEVTPDEKRKECGQELLDKYLNTKSEDYIPEVTEEMVTKCA 130

Human   131 QRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKG 195
            :||:|..||:||.|.|:|.|:|||||||||||||:|::||||||||||||:||||||||||||||
Zfish   131 ERLQQEACKELFMECTKLIHDYLSVAPFADYLDSMYYSRFLQWKWLERQPITKNTFRQYRVLGKG 195

Human   196 GFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALC 260
            |||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||
Zfish   196 GFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMALNEKQILEKVNSRFVVSLAYAYETKDALC 260

Human   261 LVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI 325
            |||||||||||||||||||:|||.|.|||||||||||||||||||||||||||||||||||||||
Zfish   261 LVLTLMNGGDLKFHIYHMGEAGFDEKRAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI 325

Human   326 RISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKK 390
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||
Zfish   326 RISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIEGQSPFQQRKK 390

Human   391 KIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKR 455
            ||||||||||||||.||||.:||..|:|||..||.|||:|||||:||.|.|||.|.:|:.:||||
Zfish   391 KIKREEVERLVKEVEEEYSSKFSEDAKSLCKMLLAKDPSERLGCQGGGASEVKAHLIFRSINFKR 455

Human   456 LGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETEC 520
            |.|||||.||.|||||||||||||||||||||||||||.|..||.|.:||||||||||||:||||
Zfish   456 LAAGMLEAPFIPDPQAIYCKDVLDIEQFSTVKGVELEPKDDSFYSKVSTGSVPIPWQNEMIETEC 520

Human   521 FQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQ 559
            |:|||:..|||:|||||||:|||..|||:|||||||.||
Zfish   521 FKELNILNLDGTVPPDLDWRGQPSPPPKQGLLQRLFGRQ 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK6	NP_002073.2	N-terminal	1..185		137/183 (75%)
		RGS	35..179	CDD:470619	99/143 (69%)
		STKc_GRK6	185..469	CDD:270779	256/283 (90%)
grk6	XP_689783.3	None