Protein Alignment GRK6 and Gprk2

DIOPT Version :10

• Sequence 1: NP_002073.2
• Gene: GRK6 / 2870
• HGNCID: 4545
• Length: 589
• Species: Homo sapiens
• Sequence 2: NP_476867.1
• Gene: Gprk2 / 49045
• FlyBaseID: FBgn0261988
• Length: 714
• Species: Drosophila melanogaster
• Alignment Length: 710
• Identity: 355/710 - (50%)
• Similarity: 430/710 - (60%)
• Gaps: 144/710 - (20%)

Human     1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRL 65
            |||||||||||.|||||||..:.||||||||::|||||||||..|:..|:..|..:.::|||||.
  Fly     1 MELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65

Human    66 LFREFCAT-RPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFL------------------- 110
            |||.||.. ||...|.:.|||.|.:||:.....|...|..:.:.||
  Fly    66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130

Human   111 -------------------------------------------------------SHTGPD---- 116
                                                                   :|.|.|
  Fly   131 ETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGN 195

Human   117 --------------------------------------------LIPEVPR-QLVTNCTQRLEQG 136
                                                        |:.:|.. .|:.....:|..|
  Fly   196 GSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNSG 260

Human   137 PCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVC 201
            . ||:|.:.......:|:..||.::..|:||:|:|||||||.||:|..|||.|||||||||||||
  Fly   261 G-KDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVC 324

Human   202 ACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLM 266
            |||||||||||||||||||||||||||:|.|.|||||:|:||.|||:||||||||||||||||:|
  Fly   325 ACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIM 389

Human   267 NGGDLKFHIYHM-GQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDL 330
            ||||||||||:| |:.||...||.|||||:.|||:.||::.|||||.||||||||||||:|||||
  Fly   390 NGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDL 454

Human   331 GLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKRE 395
            ||||.:|||:.::|||||||||||||:.||:|.|||||::.||||||||.||:||:.||:|:|||
  Fly   455 GLAVEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKRE 519

Human   396 EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGG--SAREVKEHPLF--KKLNFKRL 456
            ||:|.|||.||:||.:|:.:|:|:|.|||.|...:|||||.|  ..::|..||.|  .:||::||
  Fly   520 EVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRL 584

Human   457 GAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECF 521
            .||||||||.|||.|:|.|||||||||||||||.::.:|.:||.||.||||.|.|||||:|||||
  Fly   585 EAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETECF 649

Human   522 QELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQRIAVETAATARKSSPPASSPQP 581
            :||||||.:....|||.... .|.|.|.|...  |.|           :|..|..:.|.|
  Fly   650 RELNVFGPEECPTPDLQINA-APEPDKAGCFP--FRR-----------KKKQPARTQPIP 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK6	NP_002073.2	N-terminal	1..185		89/307 (29%)
		RGS	35..179	CDD:470619	59/267 (22%)
		STKc_GRK6	185..469	CDD:270779	208/288 (72%)
Gprk2	NP_476867.1	RGS	35..>111	CDD:470619	32/75 (43%)
		RGS	<248..305	CDD:470619	22/57 (39%)
		STKc_GRK4_like	308..597	CDD:270756	208/288 (72%)
		S_TK_X	578..642	CDD:214529	44/63 (70%)