Protein Alignment GRK6 and ppk33

DIOPT Version :10

• Sequence 1: NP_002073.2
• Gene: GRK6 / 2870
• HGNCID: 4545
• Length: 589
• Species: Homo sapiens
• Sequence 2: NP_588234.1
• Gene: ppk33 / 2539202
• PomBaseID: SPCC162.10
• Length: 338
• Species: Schizosaccharomyces pombe
• Alignment Length: 319
• Identity: 95/319 - (29%)
• Similarity: 154/319 - (48%)
• Gaps: 36/319 - (11%)

Human   186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKK-----RIKKRKGEAMALNEKQILEKVNSRF 245
            |:...|:|||.:..|...:.|.|.:.:|.|.:.||     :|||.:      ||..:|:.:|...
pombe    30 FKIRNVIGKGSWSTVFVVKHRQTKQRFALKCINKKKHDEHKIKKLR------NEVLLLQSLNHPL 88

Human   246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310
            :......:|.:..:.||..||.||||:   ||:.|..|.|:....:..|:...|..:|.:.:::|
pombe    89 LCKFYSEFEDETKIYLVTDLMLGGDLR---YHISQRKFNESVIRIWMVELVSALIYIHSKGVLHR 150

Human   311 DLKPENILLDDHGHIRISDLGLAVHV-------PEGQTIKGRVGTVGYMAPEVVKNERYTFSPDW 368
            |:||:|||||:.||.:::|..:|..|       ....|: |||||..|||||.:.:.......||
pombe   151 DVKPDNILLDEKGHCKLADFNVAAKVHTSSSPSKSNMTV-GRVGTPVYMAPETLIHAVSYKESDW 214

Human   369 WALGCLLYEMIAGQSPFQ--------QRKKKIKREEVERLVKEVPEEYSER---FSPQARSLCSQ 422
            |:||...||.:....||.        :..::.|....:||...:.....::   .|..|||....
pombe   215 WSLGITFYECLFQVRPFPNHLLINWIRASEEEKASSADRLSSALHISRDKKLTTISKDARSAVMA 279

Human   423 LLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIE 481
            .|..|..:||   |.|:::::.||.|..::.:.:..|.|.|.|:|....:|...:||:|
pombe   280 FLEMDIKKRL---GHSSKKLQTHPFFCSISLETVSKGNLTPIFRPKSGKVYVDPILDLE 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK6	NP_002073.2	N-terminal	1..185
		RGS	35..179	CDD:470619
		STKc_GRK6	185..469	CDD:270779	91/305 (30%)
ppk33	NP_588234.1	Protein Kinases, catalytic domain	29..302	CDD:473864	85/284 (30%)