Protein Alignment GRK6 and grk-1

DIOPT Version :10

• Sequence 1: NP_002073.2
• Gene: GRK6 / 2870
• HGNCID: 4545
• Length: 589
• Species: Homo sapiens
• Sequence 2: NP_509676.1
• Gene: grk-1 / 181212
• WormBaseID: WBGene00001708
• Length: 642
• Species: Caenorhabditis elegans
• Alignment Length: 633
• Identity: 346/633 - (54%)
• Similarity: 435/633 - (68%)
• Gaps: 49/633 - (7%)

Human     1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRL 65
            ||:||||||||.:|||| .||.:|||||||:..|||||.::|..|:..:|..|..:.|:||||:|
 Worm     1 MEIENIVANTVYIKARE-SGGQKKGKSKKWKNYLQFPHYTECLPLKTEIEVTYAFVVEKQPIGKL 64

Human    66 LFREFC-ATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLS--HTGPDLIPE------- 120
            ||.||| ||..:..:|..||..|.|||.:.||.:..  |.|..:.:|  |:.|:..|.
 Worm    65 LFHEFCQATNSQYHQCCQFLTKVEEYETSDDDGQSR--RDLASSIVSLLHSKPEDNPSGSQDEQE 127

Human   121 -----VPRQLVTNCTQRLEQG-----PCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKW 175
                 :..::::.|....:..     |..|:|.|..|||.:||:.|||.::.:|:||:|||||||
 Worm   128 FWCSFLSDEVISTCITTADSATHDDEPRSDIFTEPYRLTCQYLTDAPFKEFAESMYFHRFLQWKW 192

Human   176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240
            ||::||.|:|||.|||||||||||||||||||:|||||.|||||||:|||..|.::|||||||::
 Worm   193 LEKRPVDKHTFRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKKRVKKRHAETLSLNEKQILQR 257

Human   241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305
            :||.||||||||||||||||||||||||||||||:|::...||.|.|..||||||..||:.||.|
 Worm   258 INSPFVVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLMPGGFDEKRVQFYAAEITLGLQHLHSE 322

Human   306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWA 370
            ||:|||||||||||||.||:|||||||||.:.:.:.||||||||||||||:||||||::..|||.
 Worm   323 RILYRDLKPENILLDDFGHVRISDLGLAVEIKDNEPIKGRVGTVGYMAPEIVKNERYSYGVDWWG 387

Human   371 LGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCR 435
            :|||:||||.|::||:|||:|:|||||||.|:|..|:|||:||..||:||..||.|:|..|||||
 Worm   388 VGCLIYEMIEGKAPFRQRKEKVKREEVERRVREDQEKYSEKFSEAARTLCRGLLHKEPGFRLGCR 452

Human   436 -----GGSAREVKEHPLF---------KKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTV 486
                 ...|.|::.||.|         :.:.:|::.||.:.|||.|||:|:|.||||||||||||
 Worm   453 RVGRPEDGAEEIRAHPFFNTADTVTGREPVPWKKMEAGKVTPPFCPDPRAVYAKDVLDIEQFSTV 517

Human   487 KGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVF-GLDGSV-----PPDLDWKGQPPA 545
            |||.|:.||..||.||.||.|.||||:||:|||||.|||.| ..||:|     |..::...:...
 Worm   518 KGVRLDATDTQFYGKFNTGCVSIPWQSEMIETECFAELNTFHDEDGNVMWNLRPDGINMDERRNG 582

Human   546 PPKKGLLQRLFSRQRIAVETA------ATARKSSPPASSPQPEAPTSS 587
            ..|.|...|||.::.|.|..:      ....:..||.:|.|..|..||
 Worm   583 TSKPGFFSRLFRKKNIEVTKSLHDLSHLGVEQQQPPKTSTQTPAVRSS 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK6	NP_002073.2	N-terminal	1..185		88/203 (43%)
		RGS	35..179	CDD:470619	61/163 (37%)
		STKc_GRK6	185..469	CDD:270779	196/297 (66%)
grk-1	NP_509676.1	RGS	34..196	CDD:470619	61/163 (37%)
		Protein Kinases, catalytic domain	202..500	CDD:473864	196/297 (66%)