Protein Alignment GRK6 and grk6

DIOPT Version :10

• Sequence 1: NP_002073.2
• Gene: GRK6 / 2870
• HGNCID: 4545
• Length: 589
• Species: Homo sapiens
• Sequence 2: XP_002936988.1
• Gene: grk6 / 100379796
• XenbaseID: XB-GENE-1004800
• Length: 575
• Species: Xenopus tropicalis
• Alignment Length: 559
• Identity: 461/559 - (82%)
• Similarity: 505/559 - (90%)
• Gaps: 0/559 - (0%)

Human     1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRL 65
            ||||||||||||||||||||||||||||||||||||||||.|||||.||||||||||:|||||||
 Frog     1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISDCEELRRSLERDYHSLCDRQPIGRL 65

Human    66 LFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEVPRQLVTNCT 130
            |||:||.|||||.|||.|||.||||||:||:|||.||:||.:.:|:.|..|.|.|||..:|.:||
 Frog    66 LFRQFCETRPELLRCVRFLDAVAEYEVSPDEKRKECGQQLIEKYLTATSEDYITEVPEHMVLSCT 130

Human   131 QRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKG 195
            :.||..|||:||:|.::|.|::||:|||:|||||:|:|||||||.||||||||||||||||||||
 Frog   131 ESLEINPCKELFKEPSKLVHDFLSMAPFSDYLDSLYYNRFLQWKCLERQPVTKNTFRQYRVLGKG 195

Human   196 GFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALC 260
            |||||||||||||||||||||||||||||||||:||||||||||:||||||||||||||||||||
 Frog   196 GFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMALNEKQILERVNSRFVVSLAYAYETKDALC 260

Human   261 LVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI 325
            |||||||||||||||||||.|||.|.||:|||||||||||.||:|||||||||||||||||.|||
 Frog   261 LVLTLMNGGDLKFHIYHMGDAGFDEGRAIFYAAEICCGLEHLHQERIVYRDLKPENILLDDDGHI 325

Human   326 RISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKK 390
            ||||||||||:||.||||||||||||||||||:|||||||||||||||||||||.|||||||||:
 Frog   326 RISDLGLAVHIPEDQTIKGRVGTVGYMAPEVVRNERYTFSPDWWALGCLLYEMIEGQSPFQQRKR 390

Human   391 KIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKR 455
            |||||||||||||..||||.:|||.|:|||..||.|||:|||||.|..|:|||||||||::||||
 Frog   391 KIKREEVERLVKEGQEEYSAKFSPDAQSLCKMLLLKDPSERLGCHGRGAQEVKEHPLFKQINFKR 455

Human   456 LGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETEC 520
            |.||:|||||||||||||||||||||||||||||:||.||.|||:|||||::.||||||||:|:|
 Frog   456 LEAGILEPPFKPDPQAIYCKDVLDIEQFSTVKGVDLEQTDNDFYRKFATGNICIPWQNEMVDTDC 520

Human   521 FQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQ 559
            |.||:....|||:||||||:|.|...||||||||.||||
 Frog   521 FWELSALPTDGSIPPDLDWRGLPSPQPKKGLLQRFFSRQ 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK6	NP_002073.2	N-terminal	1..185		139/183 (76%)
		RGS	35..179	CDD:470619	99/143 (69%)
		STKc_GRK6	185..469	CDD:270779	251/283 (89%)
grk6	XP_002936988.1	RGS	35..179	CDD:470619	99/143 (69%)
		STKc_GRK6	185..469	CDD:270779	251/283 (89%)