DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ANK2 and YAR1

DIOPT Version :9

Sequence 1:NP_001373103.1 Gene:ANK2 / 287 HGNCID:493 Length:4183 Species:Homo sapiens
Sequence 2:NP_015085.1 Gene:YAR1 / 855837 SGDID:S000006160 Length:200 Species:Saccharomyces cerevisiae


Alignment Length:199 Identity:54/199 - (27%)
Similarity:92/199 - (46%) Gaps:32/199 - (16%)


- Green bases have known domain annotations that are detailed below.


Human    33 GCNSEDVKEPGVWSDSNASFLRAARAGNLDKVVEYLKGGID---INTC--NQNGLNALHLAAKEG 92
            |.:||.:.:     :...:.:..||||:||.:.:.....:.   ::||  :::...|||:||..|
Yeast     2 GLHSEPLDQ-----EDQDTIILDARAGDLDSLKDIFTTLVSPELLSTCKESESDSTALHMAAANG 61

Human    93 HVGLVQ---ELLGRGSS-------VDSATKKGNTALHIASLAGQAEVVKVLVKE-GANINAQSQN 146
            |:..|:   |.:.|.:|       |:...|.||||||.|||.|:.:|||:|..| .|:...:::.
Yeast    62 HIETVRYILETVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVKLLCDEYEADPFIRNKF 126

Human   147 GFTPLYMAAQENHIDVVKYLLE------NGANQSTATEDGFTPLAVA----LQQGHNQAVAILLE 201
            |...::.|......:|..|.|:      ....:.|.|| |...:.:.    ::|...:|...|.|
Yeast   127 GHDAIFEAENSGKEEVETYFLKKYDVEPEDDEEDTQTE-GKNSVQITKGTEIEQVTKEATEALRE 190

Human   202 NDTK 205
            ...|
Yeast   191 ETEK 194

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANK2NP_001373103.1 Ank_2 35..>311 CDD:423045 53/197 (27%)
ANK repeat 80..111 CDD:293786 12/40 (30%)
ANK repeat 113..144 CDD:293786 16/31 (52%)
ANK repeat 146..171 CDD:293786 5/30 (17%)
Ank_2 202..>444 CDD:423045 1/4 (25%)
ANK repeat 212..247 CDD:293786
ANK repeat 249..280 CDD:293786
ANK repeat 282..313 CDD:293786
ANK repeat 315..345 CDD:293786
ANK repeat 348..379 CDD:293786
ANK repeat 381..411 CDD:293786
ANK repeat 414..445 CDD:293786
PHA03095 421..>706 CDD:222980
ANK repeat 447..478 CDD:293786
ANK repeat 480..511 CDD:293786
ANK repeat 513..542 CDD:293786
ANK repeat 546..571 CDD:293786
Ank_2 578..>802 CDD:423045
ANK repeat 579..604 CDD:293786
ANK repeat 612..643 CDD:293786
ANK repeat 645..676 CDD:293786
ANK repeat 678..707 CDD:293786
ANK repeat 711..742 CDD:293786
ANK repeat 744..775 CDD:293786
ANK repeat 777..806 CDD:293786
Ank_4 778..830 CDD:372654
ZU5 1013..1150 CDD:128514
UPA_2 1371..1500 CDD:375346
PspC_subgroup_1 1549..>1922 CDD:411407
PTZ00449 <1717..2161 CDD:185628
Streccoc_I_II <1843..>2027 CDD:411384
Spc7_N <2493..>2634 CDD:373822
rad2 <3031..>3565 CDD:273166
PRK14949 <3196..>3442 CDD:237863
Death_ank2 3614..3697 CDD:260066
NESP55 <3770..>3884 CDD:115071
YAR1NP_015085.1 ANK repeat 11..47 CDD:293786 8/35 (23%)
Ank_2 20..124 CDD:403870 37/103 (36%)
ANK repeat 49..90 CDD:293786 12/40 (30%)
ANK repeat 92..124 CDD:293786 16/31 (52%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2336
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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