DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ANK2 and YAR1

DIOPT Version :9

Sequence 1:	NP_001373103.1	Gene:	ANK2 / 287	HGNCID:	493	Length:	4183	Species:	Homo sapiens
Sequence 2:	NP_015085.1	Gene:	YAR1 / 855837	SGDID:	S000006160	Length:	200	Species:	Saccharomyces cerevisiae

Alignment Length:	199	Identity:	54/199 - (27%)
Similarity:	92/199 - (46%)	Gaps:	32/199 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    33 GCNSEDVKEPGVWSDSNASFLRAARAGNLDKVVEYLKGGID---INTC--NQNGLNALHLAAKEG 92
            |.:||.:.:     :...:.:..||||:||.:.:.....:.   ::||  :::...|||:||..|
Yeast     2 GLHSEPLDQ-----EDQDTIILDARAGDLDSLKDIFTTLVSPELLSTCKESESDSTALHMAAANG 61

Human    93 HVGLVQ---ELLGRGSS-------VDSATKKGNTALHIASLAGQAEVVKVLVKE-GANINAQSQN 146
            |:..|:   |.:.|.:|       |:...|.||||||.|||.|:.:|||:|..| .|:...:::.
Yeast    62 HIETVRYILETVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVKLLCDEYEADPFIRNKF 126

Human   147 GFTPLYMAAQENHIDVVKYLLE------NGANQSTATEDGFTPLAVA----LQQGHNQAVAILLE 201
            |...::.|......:|..|.|:      ....:.|.|| |...:.:.    ::|...:|...|.|
Yeast   127 GHDAIFEAENSGKEEVETYFLKKYDVEPEDDEEDTQTE-GKNSVQITKGTEIEQVTKEATEALRE 190

Human   202 NDTK 205
            ...|
Yeast   191 ETEK 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANK2	NP_001373103.1	Ank_2	35..>311	CDD:423045	53/197 (27%)
		ANK repeat	80..111	CDD:293786	12/40 (30%)
		ANK repeat	113..144	CDD:293786	16/31 (52%)
		ANK repeat	146..171	CDD:293786	5/30 (17%)
		Ank_2	202..>444	CDD:423045	1/4 (25%)
		ANK repeat	212..247	CDD:293786
		ANK repeat	249..280	CDD:293786
		ANK repeat	282..313	CDD:293786
		ANK repeat	315..345	CDD:293786
		ANK repeat	348..379	CDD:293786
		ANK repeat	381..411	CDD:293786
		ANK repeat	414..445	CDD:293786
		PHA03095	421..>706	CDD:222980
		ANK repeat	447..478	CDD:293786
		ANK repeat	480..511	CDD:293786
		ANK repeat	513..542	CDD:293786
		ANK repeat	546..571	CDD:293786
		Ank_2	578..>802	CDD:423045
		ANK repeat	579..604	CDD:293786
		ANK repeat	612..643	CDD:293786
		ANK repeat	645..676	CDD:293786
		ANK repeat	678..707	CDD:293786
		ANK repeat	711..742	CDD:293786
		ANK repeat	744..775	CDD:293786
		ANK repeat	777..806	CDD:293786
		Ank_4	778..830	CDD:372654
		ZU5	1013..1150	CDD:128514
		UPA_2	1371..1500	CDD:375346
		PspC_subgroup_1	1549..>1922	CDD:411407
		PTZ00449	<1717..2161	CDD:185628
		Streccoc_I_II	<1843..>2027	CDD:411384
		Spc7_N	<2493..>2634	CDD:373822
		rad2	<3031..>3565	CDD:273166
		PRK14949	<3196..>3442	CDD:237863
		Death_ank2	3614..3697	CDD:260066
		NESP55	<3770..>3884	CDD:115071
YAR1	NP_015085.1	ANK repeat	11..47	CDD:293786	8/35 (23%)
		Ank_2	20..124	CDD:403870	37/103 (36%)
		ANK repeat	49..90	CDD:293786	12/40 (30%)
		ANK repeat	92..124	CDD:293786	16/31 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2336
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940