DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANK2 and ank2b

DIOPT Version :9

Sequence 1:	NP_001373103.1	Gene:	ANK2 / 287	HGNCID:	493	Length:	4183	Species:	Homo sapiens
Sequence 2:	XP_021333148.1	Gene:	ank2b / 450043	ZFINID:	ZDB-GENE-041010-165	Length:	3634	Species:	Danio rerio

Alignment Length:	4292	Identity:	2244/4292 - (52%)
Similarity:	2706/4292 - (63%)	Gaps:	812/4292 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    11 HADKSIRAQGNMQELDKTPDYYGC--------NSEDVKEPGVWSDSNASFLRAARAGNLDKVVEY 67
            ||..||:..  ..|:::.||....        .|.:..|....||||.||||||||||:|||:||
Zfish     3 HAAASIKKA--RVEMEQAPDLKALEKAREKRRRSRERAERRRKSDSNTSFLRAARAGNIDKVLEY 65

Human    68 LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKV 132
            ||||:||.|.|||||||||||||||||.|||||||||||||||||||||||||||||||.:|||:
Zfish    66 LKGGVDIGTSNQNGLNALHLAAKEGHVDLVQELLGRGSSVDSATKKGNTALHIASLAGQGDVVKI 130

Human   133 LVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 197
            |.|.||||||||||||||||||:||||:|||:||||||.|||.||||||||||:||||||||.|:
Zfish   131 LSKRGANINAQSQNGFTPLYMASQENHLDVVRYLLENGGNQSIATEDGFTPLAIALQQGHNQVVS 195

Human   198 ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE---SGFTPLHIAAH 259
            |||||||||||||||||||||||||||||||||||||||||||||||||||   |||||||||||
Zfish   196 ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTENGKSGFTPLHIAAH 260

Human   260 YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 324
            ||||||||||||||||||||||||||||||||||||||||.||||||.|||||||||||||||||
Zfish   261 YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVHLLLDRGAQIDAKTRDGLTPLHCAA 325

Human   325 RSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 389
            |||||..||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||
Zfish   326 RSGHDTAVELLLERGAPMLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 390

Human   390 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 454
            ||||||||||||||||||||||||||||||||||||||:||||||:||||.||||||||||||||
Zfish   391 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRVKVMELLIKYGAFIQAITESGLTPIHV 455

Human   455 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLH 519
            ||||||||||||||||||||||:||||||||||||||||:|||||||||||:|||||||:|||||
Zfish   456 AAFMGHLNIVLLLLQNGASPDVSNIRGETALHMAARAGQMEVVRCLLRNGAMVDARAREDQTPLH 520

Human   520 IASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 584
            |||||||||||||||||||||||||.||||||||:||||.:||.:||||||||||||||||||||
Zfish   521 IASRLGKTEIVQLLLQHMAHPDAATANGYTPLHIAAREGHLDVTTVLLEAGAAHSLATKKGFTPL 585

Human   585 HVAAKYGSLDVAKLLLQRRAAADSAGK-NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYT 648
            |||:|||||:||||||||||..||||| ||||||||||||||||||||||:||||||||||||||
Zfish   586 HVASKYGSLEVAKLLLQRRAPPDSAGKQNGLTPLHVAAHYDNQKVALLLLDKGASPHATAKNGYT 650

Human   649 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 713
            |||||||||||:||:|||.|||||||.|||||.|:||||||||::|..|||.:||.::::|||||
Zfish   651 PLHIAAKKNQMEIATTLLQYGAETNIQTKQGVMPIHLASQEGHSEMAALLLQRGAQVNVTTKSGL 715

Human   714 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 778
            ||||||||||||.|.:||.|.||:.|..||||||||||||||||.||||||||.||:||.|||||
Zfish   716 TSLHLAAQEDKVGVGEILVKQGANLDQQTKLGYTPLIVACHYGNAKMVNFLLKSGASVNDKTKNG 780

Human   779 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTT 843
            |||||||||||:|||||||||:||||||.|.|||||||||:|||||||||||:|||||:.|||||
Zfish   781 YTPLHQAAQQGNTHIINVLLQYGAKPNAITVNGNTALAIARRLGYISVVDTLRVVTEEIVTTTTT 845

Human   844 ITEKHKLNVPETMTEVLDVSDEEALKQFGDHFIDGEALSDSGDDTMTGDGGEYLRPEDLKELGDD 908
            :||||||||||||||||||||||..:...|..:..:::...||||||||||||||.|||:|||||
Zfish   846 VTEKHKLNVPETMTEVLDVSDEEVRRLVDDGAMSDDSIDFEGDDTMTGDGGEYLRAEDLRELGDD 910

Human   909 SLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYL-RDSAVMDDSVVIPSHQVSTLA 972
            ||| .|:||||||||:||||||||| |..|.|||:|.:|.||. :...:|:|  ||.|:|||:|.
Zfish   911 SLP-GQYLDGMNYLRFSLEGGRSDS-RLQSLDRSYTPTHQSYYSKHYGIMED--VIYSNQVSSLG 971

Human   973 KEAERNSYRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFMVDARGGAMRGCRHNGLR 1037
            :|.|::    ||.||||||:||||||.|||..|||.:.|||||||||||||||||||||||||||
Zfish   972 RENEKD----SWETENLDNIALSSSPAHSGHCSPCHDHDNSSFLVSFMVDARGGAMRGCRHNGLR 1032

Human  1038 IIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNE 1102
            :|||||||:||||||||||||||||||||||||:|||||||||||||||||||||||||||||||
Zfish  1033 LIIPPRKCSAPTRVTCRLVKRHRLATMPPMVEGDGLASRLIEVGPSGAQFLGKLHLPTAPPPLNE 1097

Human  1103 GESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEI 1167
            ||||||||||||||||||||||||||||||||||||||||:||||.|:|||||.|:|||:|||::
Zfish  1098 GESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVILRSETGESWKEHHCEYTEEELNQV 1162

Human  1168 LNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPE 1232
            ||||||.||.||:||||||||||||||||||||||||||||||||||||||||||||:|||||||
Zfish  1163 LNGMDERLDPPEELEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPEVQAVFPE 1227

Human  1233 GALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNG 1297
            ||||||||||||.|||..::|:.:||||||||||||||||||||||||||||||||:|:|..|..
Zfish  1228 GALTKRIRVGLQTQPMSVDVVRNMLGNKATFSPIVTLEPRRRKFHKPITMTIPVPKSSADPALGS 1292

Human  1298 F-GGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFA 1361
            | ||:.|||||||||||||||||||||||||||||.|:|||||||||||||||||||:||||.||
Zfish  1293 FGGGETPTLRLLCSITGGTTPAQWEDITGTTPLTFTNDCVSFTTNVSARFWLIDCRQVQESVNFA 1357

Human  1362 SQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGK 1426
            :.:||||||||||||||:|||:|||||||||||||||||:||||||||||:||||||||||||||
Zfish  1358 TLMYREIICVPYMAKFVIFAKTHDPIEARLRCFCMTDDKMDKTLEQQENFSEVARSRDVEVLEGK 1422

Human  1427 PIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQA 1491
            ||||||||||||||||||||:|||:|||||||.||:|:||.||||||||||.|||:|.|.|.|.|
Zfish  1423 PIYVDCFGNLVPLTKSGQHHVFSFYAFKENRLALFIKIRDNTQEPCGRLSFTKEPRSFRTLSHGA 1487

Human  1492 ICNLNITLPIYTKESESDQEQEEEIDMTSEK-NDETESTETSVLKSHLVNEVPVLASPDLLSEVS 1555
            :|||||:||.|:|||:||||.:||...|..| :|:||:||||:||:||:.:.|.||||||||:||
Zfish  1488 VCNLNISLPAYSKESDSDQEPDEETSRTLGKYDDDTETTETSILKTHLIRDSPALASPDLLSDVS 1552

Human  1556 EMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTR 1620
            ||||||||||||||||.|:|||.::...|.|..||...|||||:|:||||||||:||||||||.:
Zfish  1553 EMKQDLIKMTAILTTDSSEKAGPMQGDYLGKGVEEVSAEPFEIMEKVKEDLEKVSEILRSGTCEK 1617

Human  1621 DESSVQSSRSERGLVEEEWVIVSDEEIEEARQKAPLEITEYPCVEVRIDK---EIKGKVEKDSTG 1682
            :||:....|..|  .:||||::::.|||||:..|..|..|....|||:::   ..||..|:....
Zfish  1618 EESAKTEHRRYR--KDEEWVLLTESEIEEAKMMAAFESQEALLKEVRVNRGSQRPKGARERSGIP 1680

Human  1683 L---VNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAVGRSSE----KEGKDIPPDETQSTQKQ 1740
            :   ..||.|       .|..|            |..:..|.:|    :.|:.|.|...:.| |.
Zfish  1681 IGEVKEYLLD-------APASQ------------ETSSQQRFTEVVLRRGGRKIVPTMAKDT-KA 1725

Human  1741 HKPSLGIKKPVRRKLKEKQKQKEEGLQASAEKAELKKGSSEESLGEDPGLAPEPLPTVKA-TSPL 1804
            |  :..||||||||..:....:.:.:......|....|.:.|   ||..| |.|....|: .||:
Zfish  1726 H--TTEIKKPVRRKGPQGHTDETQSISTKENIASKSAGKASE---EDAFL-PVPGDQKKSPVSPV 1784

Human  1805 IEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRVKGKEDVPKKTTHRPHPAASPSLKSERHAPGS 1869
            :||||||.||:|||||||:||:||||..|
Zfish  1785 VEETPIGPIKEKVKALQKKVEEEQKGHKK------------------------------------ 1813

Human  1870 PSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKT 1934
                           :|.:.||..           |..|||       |..|.:|
Zfish  1814 ---------------QTSQKPPFK-----------STEAKT-------SVLKDQK---------- 1835

Human  1935 ERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVS 1999

Zfish  1836 ----------------------------------------------------------------- 1835

Human  2000 TAGKTEKHLPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAK 2064
            |.|..:..||...|...      ||.::.||:||||||||||:|||:||||||.|:|||||
Zfish  1836 TTGLKKTSLPQKQSSSK------SPKTEPERLEETMSVRELMRAFQTGQDPSKRKSGLFEH---- 1890

Human  2065 QKQPQEKGKVRVEKEKGPILTQREAQ-KTENQTIKRGQRLPVTGTAESKRGVRVSSIGVKKEDAA 2128
                           |||..|:.... |:|.:| ...|.||.:.:.|
Zfish  1891 ---------------KGPSKTEHTTMIKSEAKT-TNSQCLPHSSSRE------------------ 1921

Human  2129 GGKEKVLSHKIPEPVQSVPEEESHRESEVPKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELED 2193
                  :|..:..||      |.|.|.||           .|.....::|     |.|.|||
Zfish  1922 ------VSLDVSRPV------EHHEEKEV-----------FDKDAKENQK-----SHVCKQE--- 1955

Human  2194 NDKYQQFRLSE------ETEKAQLHLDQVLTSPFNTTFPLDYMK--DEFLPALSLQSGALDGSSE 2250
                   |..|      |:...|        |...|....:..|  .:.||....::|..:.||:
Zfish  1956 -------RSGEGLVFGVESAGQQ--------SSMTTAIAQNVSKHASDLLPDNGTENGTFNDSSD 2005

Human  2251 SLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQTGETKESTKTE 2315
            |:|.|.:..||..||.|....:|||||.||||:||||||||||||.||::...|:...|.|..|.
Zfish  2006 SIKLEALVDSPSASLAEVEAPLSSEESCKHEGMAETPETSPESLSLSPQQKASQSILAKASNSTA 2070

Human  2316 TTTEIRSEKEHPTTKDITGGSEERGATVTEDSETSTESFQ-KEATLGSPKDTSPKRQDDCTGSCS 2379
            .|.:.::.|                .:|:..:|..|:..| .|||:..|
Zfish  2071 DTHKAKTSK----------------VSVSFSAEMKTKIEQASEATVHHP---------------- 2103

Human  2380 VALAKETPTGLTEEAACDE---------GQRTF-----------GSSAHK-TQTDSEVQESTATS 2423
             ||:|........|:.|..         |::||           .|.:.| |:..||..||..:.
Zfish  2104 -ALSKAVDEPTKSESMCIPHRKKGVNFGGEQTFVDKDIVSISTKSSKSRKLTKRPSETLESFLSD 2167

Human  2424 DET-KALPLPEASVKTDTGTESKPQGVIRSPQGLELALPSRDSEVLSAVADDSLAVSHKDSLEAS 2487
            ||: ...|.|..:........::..|      ||.|.|..:|||.||.|||||..:|||||||.|
Zfish  2168 DESCDGQPTPTFADSLTLRAATQDHG------GLVLPLRHQDSETLSPVADDSFNISHKDSLEGS 2226

Human  2488 PVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGI-FPSHFPLPAAVAKTELLTEVA- 2550
            |::|||||||||||:||||.|||||.||||:||:|  ||:.: ||.....| :|....|.:..|
Zfish  2227 PLMEDNSSHKTPDSIEPSPTKESPCCDSLENSPIE--MKSNLAFPPTVEQP-SVTTGPLTSSKAP 2288

Human  2551 -----SVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTD---VSTP 2607
                 |:|:|:|::.:.:.:|||.||.|||.|||||||||||||||||||||.|:..|   :..|
Zfish  2289 QIPPDSLRNRMLKEQEANVDDDSCEQASLMTSSGKSPLSPDTPSSEEVSYEVNPQPPDPMVLIVP 2353

Human  2608 -KPAVIHECAEEDDSENGE--KKRFTPEEEMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSS 2669
             |.:||.|...|||....:  :::||||||||||..|||.|||:||:||.|||.:|:.:..::..
Zfish  2354 FKASVIPEETVEDDELKCDLTQRKFTPEEEMFKMAAKIKTFDEMEQDAKDKRDSRKDSEASQTLV 2418

Human  2670 SSDPDADCSVDVDE---------PKHTGSGEDESGVPVLVTSESRKVSSSSESEPELAQLKKGAD 2725
            .|        |:.:         .||..|..|:.|.     .||::.|..:.|
Zfish  2419 VS--------DIGQEIITLFGLVSKHETSSVDDVGF-----IESKQASEIARS------------ 2458

Human  2726 SGLLPEPVIRVQPPSPLPSSMDSNSSPEEVQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHL 2790
                .||:|:||||||.|:.:                           .:.|..:|:.:.:.:|
Zfish  2459 ----VEPIIKVQPPSPFPAGI---------------------------HKSPQTAEDIQQTMAH- 2491

Human  2791 AEDRHAVSTEAEDRSYDKLNRDTDQPKICDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIY 2855
                                                    |:|:...|.::.|
Zfish  2492 ----------------------------------------SAASSDESAMRRP------------ 2504

Human  2856 KESLALQGTHEKDTEGEELDVSRAESPQADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQK 2920
                  |...||.|          ..|.   |.||.|...: ..|:.||..||::..|:.|::
Zfish  2505 ------QSVTEKHT----------IKPH---PQESHSEKFN-QECVKSELAELNKTASSRSNL-- 2547

Human  2921 TEVTKTDETFENLPKDCPSQDSSITTQTDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFS 2985
             ....|||          .::.|:..|           .:.|::|||..::.:...|..:....:
Zfish  2548 -AANITDE----------QKEQSLAKQ-----------KINESEEIYSHEMQNQAANFQNVDKLA 2590

Human  2986 SEESKTQTD------ANHT-TSFHSSEVYSVTITS-PVEDVVVASSSSGTVLSKESNFEGQDIKM 3042
            |:|.:..||      ..|. ||:..|...|:.|.| ||                   ..||: |.
Zfish  2591 SQEERNVTDEIKGDYMRHAGTSYDDSCSSSLNIDSMPV-------------------IIGQN-KE 2635

Human  3043 ESQQESTLWEMQSDSVSSSFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVK 3107
            ..:.|..::: .::......||..:.:..|..:           .::|||:.:|||||||.||||
Zfish  2636 TFKPEICIYD-DTEEDDGEEEPPKTESRGVTAK-----------AETDSWNSMREDDEAFAARVK 2688

Human  3108 EEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYA 3172
            ||||||.||:|||.|||.||||||||||||:|||||||||||||||||||||||||||||||||.
Zfish  2689 EEEQKILGLVVDRHSQGATPDTTPARTPTEDGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYE 2753

Human  3173 DESFHFFQIGQESREETLSEDVKE-------GATGADPLPLETSAE-----SLALSESKETVDDE 3225
            :|.|.|:||     |..:.|.|.|       ||:|        .||     :|:|....|..:|:
Zfish  2754 EEGFAFYQI-----EHPIMEGVAEEGGNESGGASG--------DAEKEVGCNLSLQIKAEEEEDQ 2805

Human  3226 ----ADLLPDDVSEEVEEI--PASDAQLNSQ--MGISASTETPTKEAVSVGTKDLPTVQTGDIPP 3282
                |||.....:.:..::  |.:..:.:|:  .|:|...|..:.:.:|.|
Zfish  2806 PKVAADLSVRSATAKQSDLSKPKTPIKTDSEKGQGVSEKVEIKSDKVISEG-------------- 2856

Human  3283 LSGVKQISCPDSSEPAV-QVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSVIEIPTAPMENVPFTE 3346
                ..||...||:..: .:|...||:||||:|.:..:|.|||||:|.||||.|..|.:.....:
Zfish  2857 ----HLISDSGSSDTVIASIQTAVSTVTRSVHSQQEQESSDSSPEDQHSVIEQPKTPEKKESHGK 2917

Human  3347 SKSKIPVRTMPTSTPAPPSAEYESSVSEDFLSSVDEENKADEAKPKSKLPVKVPLQRVEQQLSDL 3411
            ..|||       .|.|.||...:.::|    ||.:||      ||||::|||.
Zfish  2918 LGSKI-------HTAASPSTTSKKNMS----SSKEEE------KPKSRIPVKA------------ 2953

Human  3412 DTSVQKTVAPQGQDMAS---IAPDNRSKSESDASSLDSKTKCPVKTRSYTETETESR-ERAEELE 3472
             .|::..:....:|..|   |.|.:|.||::|...|........|.:|:.|:::..: .:.::..
Zfish  2954 -NSLRSELLEPAKDKKSKLPIKPQSRRKSDTDTGPLIPTITKSSKAKSFCESDSSKKPAKKDQNR 3017

Human  3473 LESEEGATRPKILTSRLPVKSR-------STTSSCRGGTSPTKESKEHFFDLYRNSIEFFEEISD 3530
            ..|.:.::..|.|.|||||:.:       ||.:..:.| .||..:||        .:.||||||.
Zfish  3018 PTSTDLSSTTKTLPSRLPVRGKPGQPIQTSTPAKQKKG-RPTHTNKE--------PVVFFEEISQ 3073

Human  3531 EASKLVDRLTQSEREQE---IVSDDESSSALEVSVIENLPPVETEHSVPEDIFDTRPIWDESIET 3592
            ||:|:|:.|.|:|::::   ::||||||: ::||||||.|.::.:...|||....||.||..:||
Zfish  3074 EAAKVVESLAQAEKDKQEAAVLSDDESST-IDVSVIENEPFLDMKMPFPEDPLVIRPRWDNPVET 3137

Human  3593 LIERIPDENGHDHAEDPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQ 3657
            .:||||.:...... |||||.:|.|.|||.||:||||||:||||||:|::.||:|||.|||||||
Zfish  3138 QMERIPADKVRSQV-DPQDEADRKESRLAVIANHLGFSWSELARELEFSDVQINQIRNENPNSLQ 3201

Human  3658 DQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETN-TEPLQERISHSYAEIEQTITLD 3721
            ||||||::.|.||:||:|::.:|::.||||||||||||:||. .:..|:..||:||||||||:||
Zfish  3202 DQSHALIRLWKEREGKNASENSLMKTLTKINRMDIVHLIETKIIQSSQDHSSHTYAEIEQTISLD 3266

Human  3722 HSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATA 3786
            ||||||.|||::.:.:..::.:.: .:.||..  |.:.|.||:|:..|:.        |||
Zfish  3267 HSEGFSALQEDMDSPRSGRRADVS-QRRSELV--PVVASIEDLSLNASSL--------GDS---- 3316

Human  3787 LFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTP 3851
                                                         ||.:         |::|:
Zfish  3317 ---------------------------------------------QKEL---------PDKVT-- 3325

Human  3852 AEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFE 3916
                                                   :|:|:.:|..:......|.......:
Zfish  3326 ---------------------------------------SSVVVGDSTHSFEMVGLRQQFPGTIK 3351

Human  3917 KELTEELGELEASSDEEAMVTTRVVRRRVIIQGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKI 3981
            :|:.||||.|..||:|| ::|||||||||:|||||||||||:|||||:|.||:|:.||||:|||:
Zfish  3352 QEIAEELGLLSDSSEEE-VLTTRVVRRRVVIQGDDMPEIPPQTVTEEQYTDEYGNMVVKKITRKV 3415

Human  3982 IRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEVTLCEPSILS----S 4042
            ||:|||::|.|:||:|::|..||.|.::|.|.:|||:||.|::|..:|:|||..||  ||    :
Zfish  3416 IRKYVSADGVEREEVMLEGPQQEAVTVDEADSFSKVVKRTVVRSGGDQTEVTFSEP--LSYAGAT 3478

Human  4043 TSQFQAEPVEGRRVSKVVKTTVVLGERMEKHLGDSSLATDLPSAKDDFEEALSYTGSHMKVHLPS 4107
            :|:|:.|||:||:|||||||.||.|:||||.:||.||::||||||||||:||||.....||.||.
Zfish  3479 SSKFEEEPVQGRKVSKVVKTMVVQGDRMEKLIGDPSLSSDLPSAKDDFEKALSYVEGFEKVLLPH 3543

Human  4108 LVENEILKEDGSIIKRTTMSKAITQKRAVVKDQHGKRIDLEHLEDVPEALDQDDLQRDLQQLLRH 4172
            |||.|.:|||||:::||.|.|..||||.||||...|:..||.|||..|:|..||||:.|.|||:.
Zfish  3544 LVEKETVKEDGSVVRRTRMHKTRTQKRTVVKDGEAKQTHLERLEDTAESLRPDDLQQHLHQLLQR 3608

Human  4173 FC 4174
            :|
Zfish  3609 YC 3610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANK2	NP_001373103.1	Ank_2	35..>311	CDD:423045	244/278 (88%)
		ANK repeat	80..111	CDD:293786	29/30 (97%)
		ANK repeat	113..144	CDD:293786	25/30 (83%)
		ANK repeat	146..171	CDD:293786	21/24 (88%)
		Ank_2	202..>444	CDD:423045	233/244 (95%)
		ANK repeat	212..247	CDD:293786	34/34 (100%)
		ANK repeat	249..280	CDD:293786	30/30 (100%)
		ANK repeat	282..313	CDD:293786	28/30 (93%)
		ANK repeat	315..345	CDD:293786	26/29 (90%)
		ANK repeat	348..379	CDD:293786	30/30 (100%)
		ANK repeat	381..411	CDD:293786	29/29 (100%)
		ANK repeat	414..445	CDD:293786	27/30 (90%)
		PHA03095	421..>706	CDD:222980	253/285 (89%)
		ANK repeat	447..478	CDD:293786	30/30 (100%)
		ANK repeat	480..511	CDD:293786	28/30 (93%)
		ANK repeat	513..542	CDD:293786	27/28 (96%)
		ANK repeat	546..571	CDD:293786	19/24 (79%)
		Ank_2	578..>802	CDD:423045	186/224 (83%)
		ANK repeat	579..604	CDD:293786	22/24 (92%)
		ANK repeat	612..643	CDD:293786	29/30 (97%)
		ANK repeat	645..676	CDD:293786	27/30 (90%)
		ANK repeat	678..707	CDD:293786	18/28 (64%)
		ANK repeat	711..742	CDD:293786	22/30 (73%)
		ANK repeat	744..775	CDD:293786	26/30 (87%)
		ANK repeat	777..806	CDD:293786	26/28 (93%)
		Ank_4	778..830	CDD:372654	46/51 (90%)
		ZU5	1013..1150	CDD:128514	131/136 (96%)
		UPA_2	1371..1500	CDD:375346	110/128 (86%)
		PspC_subgroup_1	1549..>1922	CDD:411407	137/383 (36%)
		PTZ00449	<1717..2161	CDD:185628	112/449 (25%)
		Streccoc_I_II	<1843..>2027	CDD:411384	17/183 (9%)
		Spc7_N	<2493..>2634	CDD:373822	80/153 (52%)
		rad2	<3031..>3565	CDD:273166	203/568 (36%)
		PRK14949	<3196..>3442	CDD:237863	73/269 (27%)
		Death_ank2	3614..3697	CDD:260066	57/82 (70%)
		NESP55	<3770..>3884	CDD:115071	7/113 (6%)
ank2b	XP_021333148.1	ANK repeat	45..76	CDD:293786	25/30 (83%)
		Ank_4	47..99	CDD:316185	44/51 (86%)
		ANK	76..198	CDD:238125	107/121 (88%)
		ANK repeat	78..109	CDD:293786	29/30 (97%)
		ANK repeat	111..142	CDD:293786	25/30 (83%)
		ANK repeat	144..173	CDD:293786	24/28 (86%)
		Ank_4	207..271	CDD:316185	60/63 (95%)
		ANK repeat	210..237	CDD:293786	26/26 (100%)
		ANK	249..370	CDD:238125	114/120 (95%)
		ANK repeat	250..281	CDD:293786	30/30 (100%)
		ANK repeat	283..314	CDD:293786	28/30 (93%)
		ANK	311..436	CDD:238125	120/124 (97%)
		ANK repeat	316..346	CDD:293786	26/29 (90%)
		ANK repeat	349..380	CDD:293786	30/30 (100%)
		ANK repeat	382..412	CDD:293786	29/29 (100%)
		ANK repeat	415..446	CDD:293786	27/30 (90%)
		Ank_4	418..469	CDD:316185	47/50 (94%)
		ANK repeat	448..479	CDD:293786	30/30 (100%)
		ANK	476..601	CDD:238125	112/124 (90%)
		ANK repeat	481..512	CDD:293786	28/30 (93%)
		ANK repeat	514..545	CDD:293786	29/30 (97%)
		ANK repeat	547..572	CDD:293786	19/24 (79%)
		ANK repeat	580..608	CDD:293786	24/27 (89%)
		ANK	614..734	CDD:238125	98/119 (82%)
		ANK repeat	614..645	CDD:293786	29/30 (97%)
		ANK repeat	647..678	CDD:293786	27/30 (90%)
		ANK	675..800	CDD:238125	96/124 (77%)
		ANK repeat	680..709	CDD:293786	18/28 (64%)
		ANK repeat	713..744	CDD:293786	22/30 (73%)
		ANK repeat	746..777	CDD:293786	26/30 (87%)
		ANK repeat	779..808	CDD:293786	26/28 (93%)
		Ank_4	780..832	CDD:316185	46/51 (90%)
		ZU5	1008..1145	CDD:128514	131/136 (96%)
		Neuromodulin_N	<1588..>1884	CDD:331332	137/473 (29%)
		DUF4045	<2885..3298	CDD:330572	188/456 (41%)
		Death_ank	3158..3241	CDD:260029	57/82 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194343131
Domainoid	1	1.000	357	1.000	Domainoid score	I5697
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG38849
OrthoDB	1	1.010	-	-		D1011028at2759
OrthoFinder	1	1.000	-	-		FOG0000917
OrthoInspector	1	1.000	-	-		oto49715
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2336
SonicParanoid	1	1.000	-	-		X1361
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	14	14.190