Protein Alignment ANK2 and unc-44

DIOPT Version :10

• Sequence 1: NP_001373103.1
• Gene: ANK2 / 287
• HGNCID: 493
• Length: 4183
• Species: Homo sapiens
• Sequence 2: NP_001367345.1
• Gene: unc-44 / 177366
• WormBaseID: WBGene00006780
• Length: 6994
• Species: Caenorhabditis elegans
• Alignment Length: 4730
• Identity: 1483/4730 - (31%)
• Similarity: 2143/4730 - (45%)
• Gaps: 1075/4730 - (22%)

Human    23 QELDKTPDYYGCNSEDVKEPGVWSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHL 87
            |...:.|:.....:....||| .::.:||||||||||:|:||:|.|:.|.||||.|.||||:|||
 Worm     9 QPQQQQPESQEVQAPAAPEPG-RAEGSASFLRAARAGDLEKVLELLRAGTDINTSNANGLNSLHL 72

Human    88 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY 152
            |:||||..:|:||:.|.:.||:||:||||||||||||||:.:|.:||:.|||:|.||.|||||||
 Worm    73 ASKEGHSEVVRELIKRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLY 137

Human   153 MAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAA 217
            |||||||.:||||||::||||:.:||||||||||||||||::.||:|||||:|||||||||||||
 Worm   138 MAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAA 202

Human   218 RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 282
            :||||.:|.|||||:||.||.||        |||||||||||||:.||..|||.:||.|::.||:
 Worm   203 KKDDTTAATLLLQNEHNPDVTSK--------SGFTPLHIAAHYGHENVGQLLLEKGANVNYQARH 259

Human   283 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 347
            .|:|||||:|.|.|||..|||.||..||::|:|.||||||||||||||||:||:.:|||:.|:||
 Worm   260 NISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTK 324

Human   348 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 412
            |||:|||||||||||:..:.||.|:|||||||:||||.|||||||||.||.|||||:.|:||:||
 Worm   325 NGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRA 389

Human   413 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 477
            ||||||||||||||||||:|||:||.|:|:|.|||||||:|||||||.:|||:.|||.||:|||.
 Worm   390 LNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVE 454

Human   478 NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 542
            .:||||.||:||||.|.:|||.|:||||.|||:|||.|||||||||||.|:||.||||..|:.:|
 Worm   455 TVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNA 519

Human   543 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 607
            .|.:.|:||||:|:|||.:||.:||:..|..:|.|||||||||:|:|||:|:|.:|||:|....|
 Worm   520 TTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLERGTPVD 584

Human   608 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 672
            ..|||.:|||||||||:|.|||:||||.|||..|.|||||||||||||||||:||||||.:.|:.
 Worm   585 IEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQFKADP 649

Human   673 NIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 737
            |..::.|.|||||::||||.::..||::.|:::.....:|||::||.||||.|.||.||..:||:
 Worm   650 NAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAE 714

Human   738 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGA 802
            .::.|..|||||.||||:|.:.||.||::.||:|..||:..||||||||||||.:.:..||::||
 Worm   715 INSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGA 779

Human   803 KPNATTANGNTALAIAKRLGYISVVDTLKVVTE-EVTTTTTTITEKHKLNVPETMTEVL------ 860
            .||..||.|.|.|:||:||||:|||:||:.||| .|.|.|||:.|::|...||.|.|.:
 Worm   780 SPNEQTATGQTPLSIAQRLGYVSVVETLRTVTETTVITETTTVDERYKPQNPEAMNETMFSESED 844

Human   861 --DVSDEEAL----KQFGDHFIDGEALSDSGDDTMTGDGGEYL-RPEDLKELGDDSLPSSQFLDG 918
              ..::.||:    |.|.|:...|  |.||....|...|.:.| |.::|:..|  ::|...
 Worm   845 EGQAAEHEAVAAHEKDFSDNLTQG--LQDSTGVHMIHTGEQLLQRSQELENGG--AIPKIN---- 901

Human   919 MNYLRYSLEGGRSDSLRSFSS----------DRSHTLSHASYLRDSAVMDDSVVIPSH------Q 967
                    .||.|.. :.|:.          ..|::.|.....|..::.......|.|      .
 Worm   902 --------SGGMSPE-KEFAKIAPVATSSPIATSNSQSFGIAPRAGSISGQFQQQPLHGAGPEDN 957

Human   968 VSTLAKEAERNSYRL----SWGTENLDNVALSSSPI--HSGRASPCLERDNSSFLVSFMVDARGG 1026
            :..|.:.|:.:....    :.|...|:|....:.||  |..:.|....|   :||:||:||||||
 Worm   958 LEELVRRAQNHPINAGNYDNGGVAMLENGHADNVPIGHHVTQPSKLQHR---TFLISFLVDARGG 1019

Human  1027 AMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKL 1091
            |||||||:|:|||:||||.:.|.|||||.:::.:||
 Worm  1020 AMRGCRHSGVRIIVPPRKASQPIRVTCRYLRKDKLA----------------------------- 1055

Human  1092 HLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHF 1156
            |    ||||:|||.|.||||::.|.|.|||||||:|:||||:||.:|||:|:|||::|..||||.
 Worm  1056 H----PPPLSEGEELASRILEMAPAGAKFLGPVILEVPHFASLRDREREIVILRSDDGQHWKEHQ 1116

Human  1157 CDYTEDELNEILN-GMD-EVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLS 1219
            .:.|||.:.|:|| ..| |.|...:||:..||.||:|.|||.|||||:|::|:.:.:||||||:.
 Worm  1117 LEATEDAVQEVLNESFDAEDLAQLDDLQTPRITRILTSDFPMYFAVVTRVRQEVHCVGPEGGVII 1181

Human  1220 STVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTI 1284
            |:|||:|||:||:|:|||.|:|.:||||:..|:|.::.||:...|||||:||||||||||||:.|
 Worm  1182 SSVVPRVQAIFPDGSLTKTIKVSVQAQPVPQEMVTRLHGNRVAVSPIVTVEPRRRKFHKPITLCI 1246

Human  1285 PVPKASSDVMLNGFGG----DAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSAR 1345
            |:|::::..||..:.|    :.||||||||||||:.|||||||||||.|||..:.|||||.||||
 Worm  1247 PLPQSNNRGMLTQYSGQQGQEPPTLRLLCSITGGSAPAQWEDITGTTQLTFTGDEVSFTTTVSAR 1311

Human  1346 FWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQEN 1410
            |||:||:..:::...|.:||.|.|.:||||||.|||:...|:|.:||.|||||||.|||||:||:
 Worm  1312 FWLMDCQTPRDAARMAQEVYNEAISIPYMAKFAVFARRTFPVEGQLRVFCMTDDKEDKTLEKQEH 1376

Human  1411 FAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVR---DTTQEPC 1472
            |..:|:|||||||:||..:::..|||||:||||......|..|:||||...||.|   |......
 Worm  1377 FKLIAKSRDVEVLKGKHQFLEFSGNLVPITKSGDQLSLFFLPFQENRLAFMVKTRSNDDNEAATE 1441

Human  1473 GRLSFMKEPKSTRGLV--HQAICNLNITLPIYTKESESDQEQEEEIDMTSEK------NDETEST 1529
            ||:.||.|||.....:  .|.||.|.|:||.||.|.::....::::....::      .|..|..
 Worm  1442 GRIGFMAEPKIRSDALPPQQPICTLAISLPEYTGEIKTAPPPKKDLTPFEQRYGSALEKDLPEFV 1506

Human  1530 ETSVLKS---------------------------------------HLVNEVPVLASPDLLSEVS 1555
            ..:|||.                                       ||..|.   |:.|.|.:..
 Worm  1507 HQNVLKGIGADWPRLGRALEVPHRDIQHIRQNYPGQECKNTLKIWIHLKKED---ANQDNLDQAL 1568

Human  1556 EM--KQDLIKMTAILTTDV----------SDKAGSIKVKELVKAA-------------EEEPGEP 1595
            ..  :.|:::..|....|.          |.|...|:..|.|.||             ..||.:|
 Worm  1569 RQIGRDDIVRSIAYGEPDALINYSQADSPSQKREPIRHFEEVPAATLVKREVRTEDLVTREPVQP 1633

Human  1596 FEIVER----VKE----------------DLEKVNEILRSGTCTRDESSVQSSRSERGLVEEEWV 1640
            ...||:    |:|                ::|:...:....|..|.|..|..  ||.|.|.||..
 Worm  1634 THHVEQATTVVQEPSYSAPVHHSPVPEEPEMEEEAPVAEMRTVVRTERHVHD--SEDGPVVEERT 1696

Human  1641 IVSDEEIEEARQKAPLEITEYPCVEVRIDKEIKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTV 1705
            |.:..|.:.|..:..::.|      |.::::.:.|.|:     :|.|.|:.:   |.|.::...|
 Worm  1697 ITTTYEDDVAVNENIVDRT------VPLNEDEQQKWEE-----LNRLADESS---PSPAQRSTIV 1747

Human  1706 QDKAGKKCEALAVGRSSEKEGKDIPPDETQSTQKQ-HKPSLGI----------------KKPVRR 1753
                            :|...:.:|.|..||.:.: |:...|.                ..|.||
 Worm  1748 ----------------AESTSEQVPEDVEQSVESESHREDDGTIVTTTVTTSHISESPSGSPTRR 1796

Human  1754 KL---KEKQKQKEEGLQASAEK-------AELKKGSSEESLGEDPGLA------PEPLPTVKATS 1802
            .:   :.:..|.|:...:.||:       ...||.::||....:.|..      ...:.|.:.|.
 Worm  1797 SVEPEEHRHSQHEDHEASGAEQHSGQDSGTTQKKETAEEGFTNEDGSVVVSKKMTRVVTTTRTTL 1861

Human  1803 PLIEETP---------IGSIKDKV----------------------KALQKRVEDEQKGRSKLPI 1836
            |...|.|         :||:||::                      ..||.....|:.|
 Worm  1862 PGEGEEPSAPDSPVESLGSVKDRIAKFEQFKTLPIDPSVSGPPPSAHTLQSEEYQEESG------ 1920

Human  1837 RVKGKEDVPKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKH 1901
            .|:...||  :|..|.   :..||||||..|       |.|::.|...::|.......:....:.
 Worm  1921 NVESAYDV--ETDRRD---SERSLKSERSIP-------EIHTSPSEEQQSEHFESAEHTEDQGRD 1973

Human  1902 SPVSPSAKTERHSP----ASSSSKTEKH-----SPVSPST--KTERHSPVSSTKTERHPPVSPSG 1955
            |  ..|.|::|..|    ..|.|:.|||     |.:.|:.  ....|:||        ||..|..
 Worm  1974 S--GRSLKSDRSIPEVQFTESDSELEKHDLHEDSHLEPTVGIVITPHTPV--------PPEHPDD 2028

Human  1956 K---TDKRP--PVSPSGRTE-KHPPVSPGR----TEKRLPVSPSGRTDKHQPVSTAGKTEKHLPV 2010
            |   .|::|  |:.||.... .|..:...|    .|....:|||   ::|...:.....:.:.|.
 Worm  2029 KEDIEDEQPQEPLEPSEPEHVAHAELKDTREYSDEELAQELSPS---EEHVSTAEIKDIKSYSPT 2090

Human  2011 S-----PSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQE 2070
            |     .|.|.:..||:.            .||..:....:.:..|.|...|..|..|:..:..:
 Worm  2091 SSDDERSSQKGKVSPPIP------------QVRHAISPSVASEVLSSHDDELAAHFVAESFEKHD 2143

Human  2071 KGKVRVEKEKGPILTQREAQKTENQTIKRGQRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVL 2135
            :|.|               :..|...:.:|
 Worm  2144 EGNV---------------ETIEQTPVYKG----------------------------------- 2158

Human  2136 SHKIPEPVQSVPEEESHRESEVPKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDKYQQF 2200
             |..|.....:..|..|.: |..:...:.::|| :|.:....:.......|...:.||:|..::.
 Worm  2159 -HHSPGQTSPIVSEHPHAQ-EYAESVTSHDEGD-NLSLKSGHEPEIARHSVASVQEEDDDDDEKS 2220

Human  2201 RLSEETEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSG-----------ALDGSSES--- 2251
            .|.:..:||.:.:..|:.:|.            .|.|:..::.           .|:|..|.
 Worm  2221 ELGDFAKKAGMIVGGVIAAPV------------ALAAVGAKAAYDALNRDDDEEKLEGHEEKEVL 2273

Human  2252 ----------LKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPET----------------- 2289
                      :::|.:   |...|.:.||::|.:| :.:|.:.||..|
 Worm  2274 TTQTTIMESPIRHEDI---PSPHLEDVTPKVSHQE-HPYEHVTETTTTVTRDYYEQPEDHREASP 2334

Human  2290 SPES-------LSFSPKKSEEQTGETKESTKTETTTEIRSEKEHPTTKDITGGSEERGATVTEDS 2347
            :|.|       :|.||..||.:...    ..|||||.:..|.:.....|.:...|.....|:|:.
 Worm  2335 APSSHVESERPISESPAVSEREPSH----IATETTTTVTREYDQEPKADQSSARESVRDLVSEEH 2395

Human  2348 E---TSTESFQKEATLGSPKDTSPKRQDDCTGSCSVALAKETPTGLTEEAACDEGQRTFGSS--- 2406
            |   ..:|...:.|....|.:|..:.|      .|..:...|.|.:|.| ..||.|....||
 Worm  2396 EHPACDSERLSEPAQSPEPVETHAESQ------FSNLVETTTTTAVTRE-FYDEDQEEQASSRAT 2453

Human  2407 ----------AHKTQTDSEVQESTATSDETKALPLPEASVKTDTGTESKPQGVIRSPQGLELALP 2461
                      :.::...:|.::|.....|....|..|.:|.|.|.|.:..:.....|...||...
 Worm  2454 KERIEQSPVASERSIVSTEHRQSPTQESEQSLEPTSEKNVHTVTETTTVTRECFEEPIASELEHA 2518

Human  2462 SRDSEVLSAVADDSLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESP------------CRD 2514
            ||:.|  ....|...:||..|:.|...|....:.....:|.:|.|  |||            .|:
 Worm  2519 SREFE--QGSNDFRRSVSPVDAQEQVDVPHSPAPSSHAESEQPVP--ESPHHIVETTTTTTVTRE 2579

Human  2515 SLESSPVEPKMKAGIFPSHFPLPAAVAKTE------LLTEVASVRSRLLRDPDGSAEDDSLEQTS 2573
            ..:.....|:..|.|    ||:|::..::|      ..|...:|...|..:|:......|...:|
 Worm  2580 FQDEEYPRPESPAEI----FPIPSSEQQSEEPHIVKETTTTTTVTRELYDEPEKGNVTFSPAPSS 2640

Human  2574 LMESSGKSPLSPDTPSSEEVSYEVTPKTTDV------------STPKPAVIH------------- 2613
            ..||..:.|.||.....|......|..||:|            |:..||..|
 Worm  2641 HAESERQVPESPVVSHQEYPHVVETTTTTNVTSNIYDDEDNVPSSEDPATQHFQQSETSVHRSHP 2705

Human  2614 ECAEEDDSEN-GEK-KRFTPEEEM-----------FKMVTKIKMFDELEQEAKQKR--------- 2656
            :..||.|.|. |.| ..|..:..|           ...|.....:|..|::.:...
 Worm  2706 DSVEESDGEGLGSKVLGFAKKAGMVAGGVVAAPVALAAVGAKAAYDAFEKDDEDDETSHSPESPV 2770

Human  2657 -DYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSGED------ESGVPVL--------VTSE--- 2703
             :|:.|..|::|:.||..|.:..:.....:|....|:      ||  |||        ||||
 Worm  2771 PEYQSEQYQDDSAQSSHTDFEHHMPESPIEHEKETEEFDHSHPES--PVLSEKEREHQVTSETTT 2833

Human  2704 SRKVSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMDSNSSPEEVQFQPVVSKQYTFK 2768
            :..|:.....|||..|..:|              |.||.|||......|.      :|....|..
 Worm  2834 TTTVTREYNDEPEDEQEHQG--------------PHSPAPSSHTEAEHPH------IVETTTTTT 2878

Human  2769 MNEDTQEEPGKSEEEKDSESHLAEDRHA---------VSTEAEDRSYDKLNRDTDQPKICDGHGC 2824
            :..:.||||.:.|.:::..|..:...|:         .:|......||:.....:|..     |.
 Worm  2879 VTREFQEEPEELEYKQEDNSRKSPSSHSQENLVTETTTTTTVTSEYYDEPEHFEEQET-----GK 2938

Human  2825 EAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEKDTEGEELDVSRAESPQAD-CPS 2888
            .:.:|||........|:||...|..........:...:..|:.::|       |::||..| ..:
 Worm  2939 SSPAPSSHVESERQVLESPVASDPRHVMETTTTTTVTRQFHDDESE-------RSDSPNRDVVEA 2996

Human  2889 ESFSSSSSLPHCLVSEG-----------KELDEDISATSSIQKTEVTKTDETFENLPKDCPSQDS 2942
            :|..||:...|...||.           |..||.:...|...:|..|:|.|.      |.|..||
 Worm  2997 QSIHSSNIESHQQFSEKDDDSQRGPSPVKSEDEPVKHESYKFETSTTETREF------DRPELDS 3055

Human  2943 SITTQTDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSE-------ESKTQTDANHTTS 3000
            ...::..:..|:|......||       |..|..:|.|:  :.||       |:||.|..  |..
 Worm  3056 ERLSEPAQSPMEVSPITTEEN-------IVRPSSSVKSE--YGSEGHVPSVIETKTTTTV--TRE 3109

Human  3001 F-------HSSEVYSVTITS--PVEDVVVASSSSGTVLSKES--------NFEGQDIKMESQQES 3048
            |       |.::..|..:.|  |.|:    ....|:.|.||:        .|..:...:|..|:.
 Worm  3110 FYDDDQDEHENQTQSEELRSSIPTEE----EEHEGSHLFKETTTTTTVTREFYDEPENVEELQDP 3170

Human  3049 TLWEMQSDSVSSSFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKI 3113
            ..    |.:.||..|..:.|:.:.|.:|  :.|....:...||.:.....:|.:|:.|..|:..
 Worm  3171 QF----SPAPSSHVESGIHASESPVAQQ--QEIPQTREFHEDSPAAQYFHEEEYESHVLTEQAP- 3228

Human  3114 FGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEG-----------KLFEMTRSGAIDMT 3167
              |:.::|.|..:.|.:..     ||. .|:...|..:.|           .|..:....|.|..
 Worm  3229 --LLTEQQHQPESGDESDG-----EGL-GSKVLGFAKKAGMVAGGVVAAPVALAAVGAKAAYDAL 3285

Human  3168 KRSYADESFHFFQIGQESREETLSEDVKEGATGADPLPLETSAESLALSESKETVDDEADLLPDD 3232
            |:...:|.       ||.||..|.:              |.|.:|...||..: :::|
 Worm  3286 KKDDDEED-------QEERESLLRQ--------------ERSIDSPHASEQSQ-IEEE------- 3321

Human  3233 VSEEVEEIPASDAQLNSQMGISASTETPTKEAVSVGTKDLPTVQTGDIPPLSGVKQISCPDSSEP 3297
             .|..||.|....:  ..:..:.:|.|.|:|..                           |..||
 Worm  3322 -HERFEESPVPSEK--HHVTETTTTTTVTREYF---------------------------DEHEP 3356

Human  3298 AVQVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSVIEIPTAPMENVPFTESKSKIPVRTMPTSTPA 3362
            .|..:::         .::|  ||..|.:....|:|..|.......|.::.|:.||.:.....|.
 Worm  3357 LVSQEIE---------GEKG--SPADSEKSLPHVVETTTTTTVTREFDKNDSESPVPSEKEQEPT 3410

Human  3363 PPSAE-YE----------------SSVSEDFLSSVDEENKADEAKPKSKLPVKVPLQRVEQQLSD 3410
            ..|.| ||                ::|:::.:.  |.:...|:.:||.:.|..|..........:
 Worm  3411 TVSREVYETAEGDEPEHHYTETTTTTVTKEVID--DSQEMGDDDEPKQESPQVVETTTTTMTSRE 3473

Human  3411 LDTSVQKTVAPQGQDMASIAPDNRSKSESDASSLDSKTKCPVKTRSY---TETETESRERAEEL- 3471
            .|.:                 |:.::||:..|.:...||.....|.:   ...|||..:..|||
 Worm  3474 YDDN-----------------DDETRSEAGDSHITETTKTTTVVREFHGEQPEETEETDEVEELP 3521

Human  3472 -ELESEEGATRPKILTSRLPVKSRSTTSSCR-------------GGTSPTKE---SKEHFFDLYR 3519
             ::|.|:..:.          .|.|:||..|             ..|:.|:|   ..|..:|..:
 Worm  3522 PKIEEEDNVSE----------YSESSTSVSREVRPDEPHIIETTTTTTVTREYHNEPEETYDDQK 3576

Human  3520 NS--IEFFEEISDEASKLV----DRLTQSEREQEIVSDDESSSAL---------EVSVIENLPPV 3569
            ::  |.|.:|..|:.|:..    ||.:..|.|:.:....|:::..         |.|.|....||
 Worm  3577 DAAPISFSQEHQDDDSQASHDQHDRESPVESEKSVKHTTETTTTTTVTRQLYDDEASEIRGESPV 3641

Human  3570 ETEHSVPEDIFDTRPIWDES---IETLIERIPDENGHDHAEDPQDEQER-----IEERLAYIA-- 3624
            .||..  |.:..|:.. |||   :.::||............|.|||.:|     .|||.:.|.
 Worm  3642 ATEEH--EHVSSTKSD-DESEQHVPSVIETTTTTTVTREFYDDQDELQREDHTQSEERRSSIPTE 3703

Human  3625 ------DHL---GFSWTELARELDFTEEQIHQIRIENPNSLQDQSHAL----------------- 3663
                  .||   ..:.|.:.||  |.:|.      ||...|||...:|
 Worm  3704 ETEHEDSHLIKETTTTTTVTRE--FYDEP------ENVEKLQDSQFSLSPSSHVESEIYVPESPV 3760

Human  3664 ------------------LKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISH- 3709
                              .:|:.|.:.:|...|.....||:..     |..|:..|...|....
 Worm  3761 AKQQEIPQTREFHEDSPAAQYFHEDEYEHQVPTEQAPLLTEQQ-----HQPESGEESDGEGFGSK 3820

Human  3710 --SYAE---------IEQTITL---DHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVS 3760
              .:|:         :...:.|   .....:..|::|  ..:..|:|.:::.:|..:.|.|....
 Worm  3821 VLGFAKKAGMVAGGVVAAPVALAAVGAKAAYDALKKE--DDEEDQEERESLIREERSFDSPHASE 3883

Human  3761 EEDISVGYSTFQDG-VPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTP 3824
            :..|...:..|::. ||..:....::|| ||   |.|.|....:.:...:||....:.:::
 Worm  3884 QSQIEKEHKRFEESPVPSEKHHDQSSAL-PQ---ESVSQPIEKESRTFNDESEFGVKSDHY---- 3940

Human  3825 GTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPR 3889
               |.:.|:::   .||.::.|..|....|::        .:|..|||..:.|:.|:.:.||||.
 Worm  3941 ---TEDDQESL---KSPKESGEAFSQFTSEKE--------QDRSDSPIHSQKEDISQFQNESSPE 3991

Human  3890 KTSLVIVESADNQPETCERLDEDAAFEKELTEEL--GELEASSDEEAMVTTRVVRRRVIIQGDDM 3952
            .     |:|.....|....|:...::....:.:.  |.:....:|:|            :.|...
 Worm  3992 D-----VKSEQPHDEEKPDLERQGSYSSGYSPKSPGGSITGLDEEKA------------LSGVQE 4039

Human  3953 PEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQG--MPQEPVNIEEGDGYS 4015
            ||..||...|.                     :..:|.|..|.:....  .|..||..|  |..:
 Worm  4040 PEDRPENFAES---------------------HEKTEATSDENLFESDKYAPASPVPSE--DSSN 4081

Human  4016 KVIKRVVLKSDTEQSEVTLCEPSILSSTSQFQA--EPVEGRR-VSKVVKTTVVLGERMEKHLGDS 4077
            :||:.....:.|.:......:.|.:..:.::.:  .||...: |.:|::||.......|....:.
 Worm  4082 RVIETTTTTTVTREHFEPEDDHSYVVESQEYSSSGSPVPSEKSVDRVIETTTTTTVTREHFEAED 4146

Human  4078 SLATDLPSAKDDFEEALSYTGSHMKVHLPSLVENEILKEDGSIIKRTTMSKAITQKRAVVKDQHG 4142
            .:.|.:.|:.||  :|.|...|...||              ..|:.||.:..:|::..|..|:
 Worm  4147 EIPTIVESSHDD--QAASPVPSEEDVH--------------EQIQTTTTTTTVTKEHFVPDDE-- 4193

Human  4143 KRIDLEHLED---------VPEALDQDDLQRDLQQLL------RHFCKED 4177
              ||.||:.:         ||   .::|..|..:...      .||..||
 Worm  4194 --IDSEHMNESDKYASGSPVP---SEEDSSRVTETTTTTTVTREHFEPED 4238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ANK2	NP_001373103.1	ANKYR	61..419	CDD:440430	251/357 (70%)
		ANK repeat	80..111	CDD:293786	18/30 (60%)
		ANK repeat	113..144	CDD:293786	21/30 (70%)
		ANK repeat	146..171	CDD:293786	20/24 (83%)
		Ank_4	149..200	CDD:372654	39/50 (78%)
		Ank_4	209..270	CDD:372654	41/60 (68%)
		ANK repeat	212..247	CDD:293786	22/34 (65%)
		ANK repeat	249..280	CDD:293786	21/30 (70%)
		ANK repeat	282..313	CDD:293786	18/30 (60%)
		ANK repeat	315..345	CDD:293786	22/29 (76%)
		ANKYR	329..617	CDD:440430	197/287 (69%)
		ANK repeat	348..379	CDD:293786	22/30 (73%)
		ANK repeat	381..411	CDD:293786	23/29 (79%)
		ANK repeat	414..445	CDD:293786	25/30 (83%)
		ANK repeat	447..478	CDD:293786	23/30 (77%)
		ANK repeat	480..511	CDD:293786	22/30 (73%)
		ANK repeat	513..542	CDD:293786	20/28 (71%)
		ANK repeat	546..571	CDD:293786	13/24 (54%)
		ANKYR	566..831	CDD:440430	155/264 (59%)
		ANK repeat	579..604	CDD:293786	17/24 (71%)
		ANK repeat	612..643	CDD:293786	22/30 (73%)
		ANK repeat	645..676	CDD:293786	23/30 (77%)
		ANK repeat	678..707	CDD:293786	13/28 (46%)
		ANK repeat	711..742	CDD:293786	16/30 (53%)
		ANK repeat	744..775	CDD:293786	17/30 (57%)
		ANK repeat	777..806	CDD:293786	17/28 (61%)
		ZU5	1013..1150	CDD:128514	69/136 (51%)
		UPA_2	1371..1500	CDD:375346	69/133 (52%)
		PTZ00121	<1580..2207	CDD:173412	144/749 (19%)
		PHA03307	1725..>2004	CDD:223039	78/363 (21%)
		rad2	<3031..>3565	CDD:273166	118/605 (20%)
		PRK12323	<3196..>3442	CDD:481241	45/262 (17%)
		Death_ank2	3614..3697	CDD:260066	25/133 (19%)
		NESP55	<3770..>3884	CDD:115071	25/114 (22%)
unc-44	NP_001367345.1	ANKYR	<22..219	CDD:440430	137/197 (70%)
		ANK repeat	32..63	CDD:293786	20/30 (67%)
		ANK repeat	65..96	CDD:293786	18/30 (60%)
		ANK repeat	98..129	CDD:293786	21/30 (70%)
		ANK repeat	131..156	CDD:293786	20/24 (83%)
		ANKYR	184..462	CDD:440430	205/285 (72%)
		ANK repeat	197..224	CDD:293786	20/26 (77%)
		ANK repeat	226..257	CDD:293786	21/30 (70%)
		ANK repeat	259..290	CDD:293786	18/30 (60%)
		ANK repeat	292..322	CDD:293786	22/29 (76%)
		ANK repeat	325..356	CDD:293786	22/30 (73%)
		ANKYR	345..627	CDD:440430	197/281 (70%)
		ANK repeat	358..389	CDD:293786	23/30 (77%)
		ANK repeat	391..422	CDD:293786	25/30 (83%)
		ANK repeat	424..455	CDD:293786	23/30 (77%)
		ANK repeat	457..488	CDD:293786	22/30 (73%)
		ANK repeat	490..519	CDD:293786	20/28 (71%)
		ANKYR	505..792	CDD:440430	164/286 (57%)
		ANK repeat	523..552	CDD:293786	14/28 (50%)
		ANK repeat	556..586	CDD:293786	18/29 (62%)
		ANK repeat	589..620	CDD:293786	22/30 (73%)
		ANK repeat	622..652	CDD:293786	23/29 (79%)
		ANK repeat	655..685	CDD:293786	13/29 (45%)
		ANK repeat	688..719	CDD:293786	16/30 (53%)
		ANK repeat	721..752	CDD:293786	17/30 (57%)
		ANK repeat	754..784	CDD:293786	18/29 (62%)
		ZU5	1008..1110	CDD:128514	69/134 (51%)
		UPA_2	1337..1472	CDD:375346	70/134 (52%)
		Death_ank	1503..1580	CDD:260029	11/79 (14%)
		PTZ00449	<1770..2112	CDD:185628	80/384 (21%)