Protein Alignment GRK5 and Grk5

DIOPT Version :10

• Sequence 1: NP_005299.1
• Gene: GRK5 / 2869
• HGNCID: 4544
• Length: 590
• Species: Homo sapiens
• Sequence 2: XP_038944728.1
• Gene: Grk5 / 59075
• RGDID: 61985
• Length: 640
• Species: Rattus norvegicus
• Alignment Length: 640
• Identity: 562/640 - (87%)
• Similarity: 575/640 - (89%)
• Gaps: 50/640 - (7%)

Human     1 MELENIVANTVLLKARE---------------------GGGGKRKGKSKKWKEILKFPHISQCED 44
            |||||||||||||||||                     |||||||||||||||||||||||||||
  Rat     1 MELENIVANTVLLKAREDYCQTCSSPTPGSNPAGKRHVGGGGKRKGKSKKWKEILKFPHISQCED 65

Human    45 LRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKY 109
            |||||||||.|||||||||||||||||||||||||||||||.|||||:||||.||.|||||||||
  Rat    66 LRRTIDRDYYSLCDKQPIGRLLFRQFCETRPGLECYIQFLDLVAEYEITPDENLGAKGKEIMTKY 130

Human   110 LTPK-----------------------------SPVFIAQVGQDLVSQTEEKLLQKPCKELFSAC 145
            |:||                             |||||||||||||||||:||||.|||||||||
  Rat   131 LSPKFWSYKITIVPRFYVGPGDLNSSPDAYAVASPVFIAQVGQDLVSQTEKKLLQSPCKELFSAC 195

Human   146 AQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK 210
            |||||:||:|:|||||||||:||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 AQSVHDYLKGDPFHEYLDSMYFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK 260

Human   211 MYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHI 275
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 MYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHI 325

Human   276 YNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD 340
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 YNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD 390

Human   341 LIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETE 405
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   391 LIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETE 455

Human   406 EVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPR 470
            ||||.||||||||||.||||||:||||||||||||||||||||||||||||||||||||||||||
  Rat   456 EVYSPKFSEEAKSICNMLLTKDSKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPR 520

Human   471 AVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPP 535
            |||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||.|
  Rat   521 AVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVPIPWQNEMIETECFKELNVFGPNGTLSP 585

Human   536 DLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS 590
            ||||:.|||||||||..|||:|||||||||||:.|||.||.|||||::|||||||
  Rat   586 DLNRSQPPEPPKKGLFHRLFRRQHQNNSKSSPTPKTSCNHRINSNHINSNSTGSS 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK5	NP_005299.1	N-terminal	1..185		171/233 (73%)
		Interaction with calmodulin	20..39		18/18 (100%)
		RGS	53..175	CDD:470619	109/150 (73%)
		STKc_GRK5	183..495	CDD:270780	308/311 (99%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:15542828	388..395		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..590		46/58 (79%)
		Sufficient for membrane localization	546..565		15/18 (83%)
Grk5	XP_038944728.1	RGS	74..225	CDD:470619	109/150 (73%)
		STKc_GRK5	233..545	CDD:270780	308/311 (99%)