Protein Alignment GRK5 and grk5l

DIOPT Version :10

• Sequence 1: NP_005299.1
• Gene: GRK5 / 2869
• HGNCID: 4544
• Length: 590
• Species: Homo sapiens
• Sequence 2: XP_005167309.1
• Gene: grk5l / 567452
• ZFINID: ZDB-GENE-081105-95
• Length: 584
• Species: Danio rerio
• Alignment Length: 583
• Identity: 422/583 - (72%)
• Similarity: 495/583 - (84%)
• Gaps: 5/583 - (0%)

Human     1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRL 65
            |||||||||||||||||||||||||:||||:|||:|||||||.:|.:.|:|||..||::||||||
Zfish     1 MELENIVANTVLLKAREGGGGKRKGRSKKWREILRFPHISQCTELNKAIERDYVCLCERQPIGRL 65

Human    66 LFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTE 130
            |||.:|||:|.|:..||.||::.:|||:||||...:|.||:.|:|..:|...: .|.:.|..:.:
Zfish    66 LFRLYCETQPELQRCIQLLDAMDDYEVSPDEKRKSRGDEIIKKFLNKQSSECV-DVAESLAERCK 129

Human   131 EKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKG 195
            |.|...||||:||.|.:::|:||.|.||.:|.:||:||||||||.|||||:||:|||||||||||
Zfish   130 ENLELSPCKEIFSDCRKALHDYLSGAPFTDYQNSMYFDRFLQWKMLERQPITKDTFRQYRVLGKG 194

Human   196 GFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALC 260
            ||||||||||||||||||||:||||||||||||:||||||||||||||:|||:||||||||||||
Zfish   195 GFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALC 259

Human   261 LVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHI 325
            |||||||||||||||||||.||||:||...|||||.|||||||||:.:|||||||||||||.|||
Zfish   260 LVLTIMNGGDLKFHIYNMGTPGFEKERVQLYAAEICCGLEDLHRESIIYRDLKPENILLDDNGHI 324

Human   326 RISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE 390
            ||||||||:|:|:|:.|||||||||||||||:||:||.:|||:||||||||||..|:||||.|||
Zfish   325 RISDLGLAIKVPDGEQIRGRVGTVGYMAPEVINNERYSMSPDWWGLGCLIYEMTAGRSPFRARKE 389

Human   391 KVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKR 455
            :||||:|::||.|.||.||.||||:.|:||:|||:||.|||||||.:.|:.||.||||:|:||||
Zfish   390 RVKREDVEKRVQEEEEEYSDKFSEDTKAICRMLLSKDPKQRLGCQTDRASGVKAHPFFKNINFKR 454

Human   456 LEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETEC 520
            ||||:|:|.||||||||||||||||||||||||||||.||:||||||:|||||||||||||||||
Zfish   455 LEAGILEPSFVPDPRAVYCKDVLDIEQFSTVKGVNLDQTDNDFYSKFATGSVSIPWQNEMIETEC 519

Human   521 FKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQ----NNSKSSPSSKTSFNHHINS 579
            |.:||||||.||.||||:.|.|||||::.||.|:|:|...    ..|:...||..|.:...||
Zfish   520 FNDLNVFGPQGTRPPDLDWNQPPEPPRRSLLDRIFRRHRPEVTITQSRVLSSSVNSVDSVTNS 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK5	NP_005299.1	N-terminal	1..185		112/183 (61%)
		Interaction with calmodulin	20..39		15/18 (83%)
		RGS	53..175	CDD:470619	61/121 (50%)
		STKc_GRK5	183..495	CDD:270780	256/311 (82%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:15542828	388..395		5/6 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..590		23/53 (43%)
		Sufficient for membrane localization	546..565		7/22 (32%)
grk5l	XP_005167309.1	RGS	35..178	CDD:470619	75/143 (52%)
		STKc_GRK4_like	184..468	CDD:270756	230/283 (81%)