DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GRK5 and ppk33

DIOPT Version :10

Sequence 1:NP_005299.1 Gene:GRK5 / 2869 HGNCID:4544 Length:590 Species:Homo sapiens
Sequence 2:NP_588234.1 Gene:ppk33 / 2539202 PomBaseID:SPCC162.10 Length:338 Species:Schizosaccharomyces pombe


Alignment Length:320 Identity:94/320 - (29%)
Similarity:153/320 - (47%) Gaps:38/320 - (11%)


- Green bases have known domain annotations that are detailed below.


Human   186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250
            |:...|:|||.:..|...:.|.|.:.:|.|.:.||:..:.|.:.:. ||..:|:.:|...:....
pombe    30 FKIRNVIGKGSWSTVFVVKHRQTKQRFALKCINKKKHDEHKIKKLR-NEVLLLQSLNHPLLCKFY 93

Human   251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPE 315
            ..:|.:..:.||..:|.||||::||   ....|.|.....:..|::..|..:|.:..::||:||:
pombe    94 SEFEDETKIYLVTDLMLGGDLRYHI---SQRKFNESVIRIWMVELVSALIYIHSKGVLHRDVKPD 155

Human   316 NILLDDYGHIRISDLGLAVKI------PEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCL 374
            |||||:.||.:::|..:|.|:      .:.::..|||||..|||||.|.:.......|:|.||..
pombe   156 NILLDEKGHCKLADFNVAAKVHTSSSPSKSNMTVGRVGTPVYMAPETLIHAVSYKESDWWSLGIT 220

Human   375 IYEMIEGQSPFRGR--------KEKVKREEVDR----------RVLETEEVYSHKFSEEAKSICK 421
            .||.:....||...        .|:.|....||          :.|.|       .|::|:|...
pombe   221 FYECLFQVRPFPNHLLINWIRASEEEKASSADRLSSALHISRDKKLTT-------ISKDARSAVM 278

Human   422 MLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIE 481
            ..|..|.|:|||   ..:.:::.||||.:::.:.:..|.|.|.|.|....||...:||:|
pombe   279 AFLEMDIKKRLG---HSSKKLQTHPFFCSISLETVSKGNLTPIFRPKSGKVYVDPILDLE 335

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GRK5NP_005299.1 N-terminal 1..185
Interaction with calmodulin 20..39
RGS 53..175 CDD:470619
STKc_GRK5 183..495 CDD:270780 94/320 (29%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:15542828 388..395 2/14 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 531..590
Sufficient for membrane localization 546..565
ppk33NP_588234.1 Protein Kinases, catalytic domain 29..302 CDD:473864 82/285 (29%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.