Protein Alignment GRK5 and grk-1

DIOPT Version :10

• Sequence 1: NP_005299.1
• Gene: GRK5 / 2869
• HGNCID: 4544
• Length: 590
• Species: Homo sapiens
• Sequence 2: NP_509676.1
• Gene: grk-1 / 181212
• WormBaseID: WBGene00001708
• Length: 642
• Species: Caenorhabditis elegans
• Alignment Length: 630
• Identity: 338/630 - (53%)
• Similarity: 420/630 - (66%)
• Gaps: 92/630 - (14%)

Human     1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRL 65
            ||:||||||||.:|||| .||::||||||||..|:|||.::|..|:..|:..|..:.:|||||:|
 Worm     1 MEIENIVANTVYIKARE-SGGQKKGKSKKWKNYLQFPHYTECLPLKTEIEVTYAFVVEKQPIGKL 64

Human    66 LFRQFCE-TRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQT 129
            ||.:||: |........|||..|.|||.:.|:                      .|..:||.|..
 Worm    65 LFHEFCQATNSQYHQCCQFLTKVEEYETSDDD----------------------GQSRRDLASSI 107

Human   130 EEKLLQKP--------------CK----ELFSACA----QSVH-----------------EYLRG 155
            ...|..||              |.    |:.|.|.    .:.|                 :||..
 Worm   108 VSLLHSKPEDNPSGSQDEQEFWCSFLSDEVISTCITTADSATHDDEPRSDIFTEPYRLTCQYLTD 172

Human   156 EPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKK 220
            .||.|:.:||:|.|||||||||::||.|:|||.|||||||||||||||||||:|||||.|:||||
 Worm   173 APFKEFAESMYFHRFLQWKWLEKRPVDKHTFRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKK 237

Human   221 RIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEE 285
            |:|||..|:::|||||||:::||.|||:||||||||||||||||:|||||||||:||:...||:|
 Worm   238 RVKKRHAETLSLNEKQILQRINSPFVVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLMPGGFDE 302

Human   286 ERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG 350
            :|..||||||..||:.||.|..:|||||||||||||:||:|||||||||:|.:.:.|:|||||||
 Worm   303 KRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHVRISDLGLAVEIKDNEPIKGRVGTVG 367

Human   351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415
            |||||::.|:||....|:||:||||||||||::|||.||||||||||:|||.|.:|.||.||||.
 Worm   368 YMAPEIVKNERYSYGVDWWGVGCLIYEMIEGKAPFRQRKEKVKREEVERRVREDQEKYSEKFSEA 432

Human   416 AKSICKMLLTKDAKQRLGCQ-----EEGAAEVKRHPFFRNMN---------FKRLEAGMLDPPFV 466
            |:::|:.||.|:...||||:     |:||.|::.||||...:         :|::|||.:.|||.
 Worm   433 ARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFFNTADTVTGREPVPWKKMEAGKVTPPFC 497

Human   467 PDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVF---- 527
            |||||||.|||||||||||||||.||.||..||.||:||.||||||:||||||||.|||.|
 Worm   498 PDPRAVYAKDVLDIEQFSTVKGVRLDATDTQFYGKFNTGCVSIPWQSEMIETECFAELNTFHDED 562

Human   528 -------GPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKS 565
                   .|:| :..|..||...:|   |...|||::::...:||
 Worm   563 GNVMWNLRPDG-INMDERRNGTSKP---GFFSRLFRKKNIEVTKS 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK5	NP_005299.1	N-terminal	1..185		83/223 (37%)
		Interaction with calmodulin	20..39		13/18 (72%)
		RGS	53..175	CDD:470619	45/161 (28%)
		STKc_GRK5	183..495	CDD:270780	218/325 (67%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:15542828	388..395		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..590		11/35 (31%)
		Sufficient for membrane localization	546..565		4/18 (22%)
grk-1	NP_509676.1	RGS	34..196	CDD:470619	55/183 (30%)
		Protein Kinases, catalytic domain	202..500	CDD:473864	194/297 (65%)