Protein Alignment GRK5 and Grk5

DIOPT Version :10

• Sequence 1: NP_005299.1
• Gene: GRK5 / 2869
• HGNCID: 4544
• Length: 590
• Species: Homo sapiens
• Sequence 2: NP_061357.3
• Gene: Grk5 / 14773
• MGIID: 109161
• Length: 590
• Species: Mus musculus
• Alignment Length: 590
• Identity: 562/590 - (95%)
• Similarity: 575/590 - (97%)
• Gaps: 0/590 - (0%)

Human     1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRL 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||
Mouse     1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYYSLCDKQPIGRL 65

Human    66 LFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTE 130
            ||||||||||||||||||||.|||||:||||.||.||||||||||||||||||||||||||||||
Mouse    66 LFRQFCETRPGLECYIQFLDLVAEYEITPDENLGAKGKEIMTKYLTPKSPVFIAQVGQDLVSQTE 130

Human   131 EKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKG 195
            :||||.||||||||||||||:||:|:|||||||||:|||||||||||||||||||||||||||||
Mouse   131 KKLLQSPCKELFSACAQSVHDYLKGDPFHEYLDSMYFDRFLQWKWLERQPVTKNTFRQYRVLGKG 195

Human   196 GFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALC 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 GFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALC 260

Human   261 LVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHI 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 LVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHI 325

Human   326 RISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 RISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE 390

Human   391 KVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKR 455
            |||||||||||||||||||.||||||||||.||||||:|||||||||||||||||||||||||||
Mouse   391 KVKREEVDRRVLETEEVYSSKFSEEAKSICNMLLTKDSKQRLGCQEEGAAEVKRHPFFRNMNFKR 455

Human   456 LEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETEC 520
            ||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||
Mouse   456 LEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVPIPWQNEMIETEC 520

Human   521 FKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSN 585
            |||||||||||||.|||||:.|||||||||..|||:||||:||||||:.|||.||.|||||::||
Mouse   521 FKELNVFGPNGTLSPDLNRSQPPEPPKKGLFHRLFRRQHQSNSKSSPTPKTSCNHRINSNHINSN 585

Human   586 STGSS 590
            |||||
Mouse   586 STGSS 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK5	NP_005299.1	N-terminal	1..185		172/183 (94%)
		Interaction with calmodulin	20..39		18/18 (100%)
		RGS	53..175	CDD:470619	110/121 (91%)
		STKc_GRK5	183..495	CDD:270780	308/311 (99%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:15542828	388..395		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..590		45/58 (78%)
		Sufficient for membrane localization	546..565		14/18 (78%)
Grk5	NP_061357.3	N-terminal	1..185		172/183 (94%)
		Interaction with calmodulin. /evidence=ECO:0000250	20..39		18/18 (100%)
		RGS	53..175	CDD:470619	110/121 (91%)
		STKc_GRK5	183..495	CDD:270780	308/311 (99%)
		Nuclear localization signal. /evidence=ECO:0000250	388..395		6/6 (100%)
		Sufficient for membrane localization. /evidence=ECO:0000250	546..565		14/18 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	557..590		25/32 (78%)