Protein Alignment GRK5 and grk5

DIOPT Version :10

• Sequence 1: NP_005299.1
• Gene: GRK5 / 2869
• HGNCID: 4544
• Length: 590
• Species: Homo sapiens
• Sequence 2: XP_002940394.1
• Gene: grk5 / 100497344
• XenbaseID: XB-GENE-1008485
• Length: 590
• Species: Xenopus tropicalis
• Alignment Length: 590
• Identity: 506/590 - (85%)
• Similarity: 549/590 - (93%)
• Gaps: 0/590 - (0%)

Human     1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRL 65
            |||||||||||||||||||||||||||||||||||||||||||:|||..:|||.:||:|||||||
 Frog     1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEELRRATERDYYNLCEKQPIGRL 65

Human    66 LFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTE 130
            |||||||.:|.|||.|.|||:|||||||||||||||||||:.|||||:|||::::||||:|.|.|
 Frog    66 LFRQFCEAQPDLECLIHFLDAVAEYEVTPDEKLGEKGKEIILKYLTPESPVYVSEVGQDIVHQME 130

Human   131 EKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKG 195
            |||...|.|||||.||:||.::|.|||||.||:||:|||||||||||||||||||||||||||||
 Frog   131 EKLEISPYKELFSHCAKSVSDFLSGEPFHCYLESMYFDRFLQWKWLERQPVTKNTFRQYRVLGKG 195

Human   196 GFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALC 260
            ||||||||||||||||||||||||||||||||||||||||||||||.|:||||||||||||||||
 Frog   196 GFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVTSRFVVNLAYAYETKDALC 260

Human   261 LVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHI 325
            ||||:||||||||||||||||||:||||.||||||||||.|||||:.||||||||||||||||||
 Frog   261 LVLTLMNGGDLKFHIYNMGNPGFQEERASFYAAEILCGLGDLHRESIVYRDLKPENILLDDYGHI 325

Human   326 RISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE 390
            |||||||||||||||.|||||||||||||||||||:|..|||:|||||||||||.||||||||||
 Frog   326 RISDLGLAVKIPEGDSIRGRVGTVGYMAPEVLNNQKYTFSPDFWGLGCLIYEMIAGQSPFRGRKE 390

Human   391 KVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKR 455
            ||||||||||||||||||:.||||||||:||:||||:.|:||||||.||.:||||||||.:||||
 Frog   391 KVKREEVDRRVLETEEVYTQKFSEEAKSVCKLLLTKEVKRRLGCQEGGAVDVKRHPFFRVINFKR 455

Human   456 LEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETEC 520
            ||||::|||||||||||||||||||||||||||||||.||||||:|||||||||||||||.||||
 Frog   456 LEAGIMDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDQTDDDFYTKFSTGSVSIPWQNEMTETEC 520

Human   521 FKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSN 585
            ||||||:|||.||.|||||:||||||||.||.|:|||||||||.|||.:|:|.||.:|:||:|:|
 Frog   521 FKELNVYGPNRTLSPDLNRSHPPEPPKKSLLHRIFKRQHQNNSNSSPCTKSSLNHDVNTNHISTN 585

Human   586 STGSS 590
            |||||
 Frog   586 STGSS 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK5	NP_005299.1	N-terminal	1..185		147/183 (80%)
		Interaction with calmodulin	20..39		18/18 (100%)
		RGS	53..175	CDD:470619	89/121 (74%)
		STKc_GRK5	183..495	CDD:270780	282/311 (91%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:15542828	388..395		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..590		42/58 (72%)
		Sufficient for membrane localization	546..565		15/18 (83%)
grk5	XP_002940394.1	RGS	53..175	CDD:470619	89/121 (74%)
		STKc_GRK4_like	185..469	CDD:270756	255/283 (90%)