Protein Alignment GRK4 and Grk4

DIOPT Version :10

• Sequence 1: XP_011511749.1
• Gene: GRK4 / 2868
• HGNCID: 4543
• Length: 617
• Species: Homo sapiens
• Sequence 2: XP_063129586.1
• Gene: Grk4 / 59077
• RGDID: 61858
• Length: 647
• Species: Rattus norvegicus
• Alignment Length: 613
• Identity: 429/613 - (69%)
• Similarity: 494/613 - (80%)
• Gaps: 55/613 - (8%)

Human     1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRR 65
            |||||.:||:||||||| |:.||:||||||:|:|.|||||.||:||||||||:|||||:|||||.
  Rat     1 MELENFMANTLLLKARQ-GFTKKTGRSKKWRELLKLPPVSMCSDLRHSIEKDFSSLCDQQPIGRL 64

Human    66 LFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECR 130
            ||||||:|||.|||.||||||.|||||..:|::.:.||||..|||.:.....||:||||:|.||:
  Rat    65 LFRQFCNTKPDLKRCIEFLDAAAEYEVTIEEEQREFGLSIYSRFFKENSEVSLPQIPPDLVKECK 129

Human   131 LGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGK 195
            ..||:.:||:..|::|..|.:.||..:||||||||:|:::|||||||||:||||||||.||||||
  Rat   130 CNLKQSSPSQNVFQDCAGVIYKYLSEKPFEEYQESTYYNRFLQWKWLERRPVTKNTFRQYRVLGK 194

Human   196 GGFGEQSPVGCAVDGSWKKQQPNVDDTEARGPEPEAHDTIFSTFVCACQVRATGKMYACKKLQKK 260
            |||||                                       ||||||||||||||||||:||
  Rat   195 GGFGE---------------------------------------VCACQVRATGKMYACKKLEKK 220

Human   261 RIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDE 325
            ||||||||||||||||||||:.|||||||||.||||||||||||||||||||:||||||||||:|
  Rat   221 RIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGNPGFEE 285

Human   326 QRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVG 390
            ||||||||||||||||||||||||||||||||||||.|||||||||||.|||||:.|||||||||
  Rat   286 QRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDHGHIRISDLGLALEIPEGEMVRGRVGTVG 350

Human   391 YM--------------APEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRI 441
            ||              |||::::||||||||||||||||||||.|||||:||||||..||:::|:
  Rat   351 YMACVSGFFIKNRVSIAPEIISHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREEMERRV 415

Human   442 KNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFC 506
            |.:||||||:|||:|||||.|||||:|||||||:.:||:.|||||:||||||.|||||||:||||
  Rat   416 KTETEEYSERFSENAKSICSMLLTKDPSKRLGCQSDGASAVKQHPIFKDINFSRLEANMLDPPFC 480

Human   507 PDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEE 571
            |||.|:||||:|||.|||||||:.|||.||.||.:||||||:|||||||||||||||:|:.|.:.
  Rat   481 PDPEAIYCKDILDIGQFSVVKGVNLDTNDEIFYTQFATGCVTIPWQNEMIESGCFKDLNEYEDKG 545

Human   572 ALPLDLDKNIHTPVSRPNRGFFYRLFRR 599
            ..||:..| |.:.:.||.|.||:|||||
  Rat   546 LSPLEKHK-ICSCILRPKRNFFHRLFRR 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK4	XP_011511749.1	RGS	52..184	CDD:470619	80/131 (61%)
		STKc_GRK4	186..509	CDD:173720	246/336 (73%)
Grk4	XP_063129586.1	None