Protein Alignment GRK4 and grk4

DIOPT Version :10

• Sequence 1: XP_011511749.1
• Gene: GRK4 / 2868
• HGNCID: 4543
• Length: 617
• Species: Homo sapiens
• Sequence 2: NP_001349548.1
• Gene: grk4 / 560761
• ZFINID: ZDB-GENE-060929-1198
• Length: 579
• Species: Danio rerio
• Alignment Length: 620
• Identity: 434/620 - (70%)
• Similarity: 489/620 - (78%)
• Gaps: 48/620 - (7%)

Human     1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRR 65
            ||:||||||::|||||:||.||::||||||||:|.||.:|||.|||.:||:||:|||:||||||:
Zfish     1 MEIENIVANTVLLKAREGGGGKRNGRSKKWKEMLKLPHISQCEELRRTIERDYTSLCEKQPIGRQ 65

Human    66 LFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECR 130
            ||||||||:|.|:|.|||||:||.|:||.||.|.|.||:|||.:||:..||.|||:..|||.|||
Zfish    66 LFRQFCDTQPKLRRCIEFLDSVAMYQVAPDEKRRDAGLNILDTYFNNGSAAHLPEMAQDVVGECR 130

Human   131 LGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGK 195
            ..| |::|.|:.|:||||:...||.|.||..|||:.|||:|||||||||||||||||||||||||
Zfish   131 QKL-EQSPCKELFQECTRIVREYLSGAPFSAYQETMYFSRFLQWKWLERQPVTKNTFRHYRVLGK 194

Human   196 GGFGEQSPVGCAVDGSWKKQQPNVDDTEARGPEPEAHDTIFSTFVCACQVRATGKMYACKKLQKK 260
            |||||                                       ||||||||||||||||||:||
Zfish   195 GGFGE---------------------------------------VCACQVRATGKMYACKKLEKK 220

Human   261 RIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDE 325
            |:|||||||||||||||||||.|.|||||||||||||||||||||||||||||||||:||.||||
Zfish   221 RVKKRKGEAMALNEKRILEKVNSSFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNSGFDE 285

Human   326 QRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVG 390
            |||:|||||:|||||||.||||||||||||||||||||||||||||||.:||||:.:||||||||
Zfish   286 QRAIFYAAEICCGLEDLHRERIVYRDLKPENILLDDRGHIRISDLGLAVQIPEGETIRGRVGTVG 350

Human   391 YMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSED 455
            ||||||:.||.||||||||||||||||||||.|||::.||:||.||||:|:..|.|||:||||||
Zfish   351 YMAPEVIQNESYTFSPDWWGLGCLIYEMIQGQSPFRRRKERVKREEVDRRVCEDQEEYTEKFSED 415

Human   456 AKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDI 520
            ||.|||.||.|:|.:||||||.|||.||.||:|::|||:|||||||:|||||||.||||||||||
Zfish   416 AKDICRQLLCKDPKERLGCRGSGAAEVKLHPIFRNINFKRLEANMLDPPFCPDPRAVYCKDVLDI 480

Human   521 EQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKNIHTPV 585
            ||||.|||:.||..|:|||.:|.||.|||||||||||..|||:||..|.:.||..|||.|...|.
Zfish   481 EQFSTVKGVNLDPTDDDFYHKFVTGSVSIPWQNEMIEMECFKEINVFEMDGALCADLDVNRPNPA 545

Human   586 SRPNRGFFYRLFRRGGCLTMVPS------EKEVEP 614
              |.||||||||.|..|.....|      |||.||
Zfish   546 --PKRGFFYRLFHREVCFGSANSEEEEKEEKEEEP 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK4	XP_011511749.1	RGS	52..184	CDD:470619	86/131 (66%)
		STKc_GRK4	186..509	CDD:173720	240/322 (75%)
grk4	NP_001349548.1	RGS_GRK4	52..183	CDD:188704	86/131 (66%)
		Protein Kinases, catalytic domain	185..469	CDD:473864	240/322 (75%)