Protein Alignment GRK4 and grk4

DIOPT Version :10

• Sequence 1: XP_011511749.1
• Gene: GRK4 / 2868
• HGNCID: 4543
• Length: 617
• Species: Homo sapiens
• Sequence 2: NP_001006112.1
• Gene: grk4 / 448587
• XenbaseID: XB-GENE-480159
• Length: 575
• Species: Xenopus tropicalis
• Alignment Length: 616
• Identity: 439/616 - (71%)
• Similarity: 500/616 - (81%)
• Gaps: 48/616 - (7%)

Human     1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRR 65
            ||:||||||::|||||:||.||::||||||||:|.||.:|||.||||:||:||.:||:||||||.
 Frog     1 MEIENIVANTVLLKAREGGGGKRNGRSKKWKEMLRLPHISQCEELRHTIERDYGNLCEKQPIGRL 65

Human    66 LFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECR 130
            ||||||||:|.|||.|||||||||||:|.||.|.|.||.|||.:||:..||.|||||.|.|.||:
 Frog    66 LFRQFCDTRPELKRCIEFLDAVAEYELAPDEKRKDHGLRILDTYFNNGSAAHLPEIPQDTVHECK 130

Human   131 LGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGK 195
            ..| |::|.|:.|::||||.|:||.|.||.::|:|.|||:|||||||||||||||||||||||||
 Frog   131 EKL-EQSPCKELFKDCTRVVHDYLSGTPFGDFQDSMYFSRFLQWKWLERQPVTKNTFRHYRVLGK 194

Human   196 GGFGEQSPVGCAVDGSWKKQQPNVDDTEARGPEPEAHDTIFSTFVCACQVRATGKMYACKKLQKK 260
            |||||                                       ||||||||||||||||||:||
 Frog   195 GGFGE---------------------------------------VCACQVRATGKMYACKKLEKK 220

Human   261 RIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDE 325
            ||||||||:||||||:|||||.|||||||||.|||||||||||||||||||||||||:|||||||
 Frog   221 RIKKRKGESMALNEKQILEKVNSRFVVSLAYTYETKDALCLVLTIMNGGDLKFHIYNMGNPGFDE 285

Human   326 QRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVG 390
            ||||||||||||||||||||||||||||||||||||||||||||||||.:||||:.:||||||||
 Frog   286 QRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLAVQIPEGESIRGRVGTVG 350

Human   391 YMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSED 455
            ||||||:|||.|||||||||||||:||||||.|||:|.|||||.:|||:|::.|.||||||||||
 Frog   351 YMAPEVINNESYTFSPDWWGLGCLVYEMIQGQSPFRKRKEKVKRDEVDRRVREDEEEYSEKFSED 415

Human   456 AKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDI 520
            |||||||||:|:|.:||||.|.||:.|||||:||:|||:|||||:|||||.|||.||||||||||
 Frog   416 AKSICRMLLSKDPKQRLGCTGSGASHVKQHPIFKNINFKRLEANILEPPFVPDPRAVYCKDVLDI 480

Human   521 EQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLD---KNIH 582
            ||||.|||:.|||.|:|||::|.||.||||||.||||:.||||||..|::..|..|||   :|:
 Frog   481 EQFSTVKGVNLDTTDDDFYSKFVTGSVSIPWQQEMIETECFKDINVYETDGCLSPDLDVSKQNL- 544

Human   583 TPVSRPNRGFFYRLFRRGGCLTMVPSEKEVE 613
                :|.|.||:||||||.|.....|:.|.|
 Frog   545 ----KPKRSFFHRLFRRGVCFKSSYSDDEEE 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK4	XP_011511749.1	RGS	52..184	CDD:470619	88/131 (67%)
		STKc_GRK4	186..509	CDD:173720	246/322 (76%)
grk4	NP_001006112.1	RGS_GRK4	52..183	CDD:188704	88/131 (67%)
		STKc_GRK4	185..469	CDD:173720	246/322 (76%)