Protein Alignment GRK4 and ppk33

DIOPT Version :10

• Sequence 1: XP_011511749.1
• Gene: GRK4 / 2868
• HGNCID: 4543
• Length: 617
• Species: Homo sapiens
• Sequence 2: NP_588234.1
• Gene: ppk33 / 2539202
• PomBaseID: SPCC162.10
• Length: 338
• Species: Schizosaccharomyces pombe
• Alignment Length: 345
• Identity: 99/345 - (28%)
• Similarity: 151/345 - (43%)
• Gaps: 51/345 - (14%)

Human   211 SWKKQQPNVDDTEARGPEPEAHDTI--------FSTFVCACQVRATGKMYACKKLQKK-----RI 262
            |.|..:.|.:|..|...|..:...|        :|| |...:.|.|.:.:|.|.:.||     :|
pombe     8 SVKNDKENFEDPNATNFESVSQFKIRNVIGKGSWST-VFVVKHRQTKQRFALKCINKKKHDEHKI 71

Human   263 KKRKGEAMALNEKR--ILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDE 325
            ||.:.|.:.|....  :|.|..|.|        |.:..:.||..:|.||||::||   ....|:|
pombe    72 KKLRNEVLLLQSLNHPLLCKFYSEF--------EDETKIYLVTDLMLGGDLRYHI---SQRKFNE 125

Human   326 QRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEI------PEGQRVRG 384
            .....:..||...|..:..:.:::||:||:|||||::||.:::|..:|.::      .:.....|
pombe   126 SVIRIWMVELVSALIYIHSKGVLHRDVKPDNILLDEKGHCKLADFNVAAKVHTSSSPSKSNMTVG 190

Human   385 RVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKY--------KEKVKWEEVDQ-- 439
            ||||..|||||.:.:.......|||.||...||.:....||..:        .|:.|....|:
pombe   191 RVGTPVYMAPETLIHAVSYKESDWWSLGITFYECLFQVRPFPNHLLINWIRASEEEKASSADRLS 255

Human   440 ---RIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANML 501
               .|..|.:  ....|:||:|.....|..:..|||   |..:..::.||.|..|:...:....|
pombe   256 SALHISRDKK--LTTISKDARSAVMAFLEMDIKKRL---GHSSKKLQTHPFFCSISLETVSKGNL 315

Human   502 EPPFCPDPHAVYCKDVLDIE 521
            .|.|.|....||...:||:|
pombe   316 TPIFRPKSGKVYVDPILDLE 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK4	XP_011511749.1	RGS	52..184	CDD:470619
		STKc_GRK4	186..509	CDD:173720	94/331 (28%)
ppk33	NP_588234.1	Protein Kinases, catalytic domain	29..302	CDD:473864	82/289 (28%)