Protein Alignment GRK4 and grk-1

DIOPT Version :10

• Sequence 1: XP_011511749.1
• Gene: GRK4 / 2868
• HGNCID: 4543
• Length: 617
• Species: Homo sapiens
• Sequence 2: NP_509676.1
• Gene: grk-1 / 181212
• WormBaseID: WBGene00001708
• Length: 642
• Species: Caenorhabditis elegans
• Alignment Length: 670
• Identity: 325/670 - (48%)
• Similarity: 420/670 - (62%)
• Gaps: 106/670 - (15%)

Human     1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRR 65
            ||:||||||::.:|||:.| |:|.|:|||||..|..|..::|..|:..||..|:.:.:|||||:.
 Worm     1 MEIENIVANTVYIKARESG-GQKKGKSKKWKNYLQFPHYTECLPLKTEIEVTYAFVVEKQPIGKL 64

Human    66 LFRQFCD-TKPTLKRHIEFLDAVAEYEVADD--EDRSDCGLSILDRFFNDKLAAPLPEIPP---- 123
            ||.:||. |.....:..:||..|.|||.:||  :.|.|...||:      .|....||..|
 Worm    65 LFHEFCQATNSQYHQCCQFLTKVEEYETSDDDGQSRRDLASSIV------SLLHSKPEDNPSGSQ 123

Human   124 ------------DVVTEC----RLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFL 172
                        :|::.|    .....::.|....|.|..|:...||...||:|:.||.||.:||
 Worm   124 DEQEFWCSFLSDEVISTCITTADSATHDDEPRSDIFTEPYRLTCQYLTDAPFKEFAESMYFHRFL 188

Human   173 QWKWLERQPVTKNTFRHYRVLGKGGFGEQSPVGCAVDGSWKKQQPNVDDTEARGPEPEAHDTIFS 237
            ||||||::||.|:|||.|||||||||||
 Worm   189 QWKWLEKRPVDKHTFRLYRVLGKGGFGE------------------------------------- 216

Human   238 TFVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLV 302
              ||||||||:|||||.|||:|||:|||..|.::||||:||:::.|.||||||||||||||||||
 Worm   217 --VCACQVRASGKMYALKKLEKKRVKKRHAETLSLNEKQILQRINSPFVVSLAYAYETKDALCLV 279

Human   303 LTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRI 367
            ||:|||||||||:|||...||||:|..|||||:..||:.|..|||:|||||||||||||.||:||
 Worm   280 LTLMNGGDLKFHLYNLMPGGFDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHVRI 344

Human   368 SDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKV 432
            ||||||.||.:.:.::||||||||||||:|.||:|::..||||:||||||||:|.:||::.||||
 Worm   345 SDLGLAVEIKDNEPIKGRVGTVGYMAPEIVKNERYSYGVDWWGVGCLIYEMIEGKAPFRQRKEKV 409

Human   433 KWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCR-----GEGAAGVKQHPVF---- 488
            |.|||::|::.|.|:|||||||.|:::||.||.|.|..|||||     .:||..::.||.|
 Worm   410 KREEVERRVREDQEKYSEKFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFFNTAD 474

Human   489 -----KDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVS 548
                 :.:.::::||..:.|||||||.|||.||||||||||.|||:.||..|..||.:|.|||||
 Worm   475 TVTGREPVPWKKMEAGKVTPPFCPDPRAVYAKDVLDIEQFSTVKGVRLDATDTQFYGKFNTGCVS 539

Human   549 IPWQNEMIESGCFKDINKSESE----------EALPLDLDKNIHTPVSRPNRGFFYRLFRRGGC- 602
            ||||:||||:.||.::|....|          :.:.:|..:|   ..|:|  |||.||||:...
 Worm   540 IPWQSEMIETECFAELNTFHDEDGNVMWNLRPDGINMDERRN---GTSKP--GFFSRLFRKKNIE 599

Human   603 -------LTMVPSEKEVEPK 615
                   |:.:..|::..||
 Worm   600 VTKSLHDLSHLGVEQQQPPK 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK4	XP_011511749.1	RGS	52..184	CDD:470619	52/154 (34%)
		STKc_GRK4	186..509	CDD:173720	190/336 (57%)
grk-1	NP_509676.1	RGS	34..196	CDD:470619	55/167 (33%)
		Protein Kinases, catalytic domain	202..500	CDD:473864	190/336 (57%)