Protein Alignment GRK4 and Grk4

DIOPT Version :10

• Sequence 1: XP_011511749.1
• Gene: GRK4 / 2868
• HGNCID: 4543
• Length: 617
• Species: Homo sapiens
• Sequence 2: NP_062370.2
• Gene: Grk4 / 14772
• MGIID: 95801
• Length: 574
• Species: Mus musculus
• Alignment Length: 617
• Identity: 433/617 - (70%)
• Similarity: 498/617 - (80%)
• Gaps: 45/617 - (7%)

Human     1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRR 65
            |||||.|||:||||||. |:.|::||||||:|:|..||||.|:|||.|||||:|||||||||||.
Mouse     1 MELENFVANNLLLKARL-GFNKQTGRSKKWRELLKFPPVSMCTELRWSIEKDFSSLCDKQPIGRL 64

Human    66 LFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECR 130
            ||||||||||.|||.||||||||||||..:|::.:.||:|..|||.:|...||||||||:|.||:
Mouse    65 LFRQFCDTKPDLKRCIEFLDAVAEYEVTIEEEQREFGLAIFSRFFKEKSEVPLPEIPPDIVKECK 129

Human   131 LGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGK 195
            ..||:.:||:..||||..:...||...||||||||:||::|||||||||:||||||||.||||||
Mouse   130 WNLKQNSPSQNVFEECAGIVCKYLSETPFEEYQESTYFNRFLQWKWLERRPVTKNTFRQYRVLGK 194

Human   196 GGFGEQSPVGCAVDGSWKKQQPNVDDTEARGPEPEAHDTIFSTFVCACQVRATGKMYACKKLQKK 260
            |||||                                       ||||||||||||||||||:||
Mouse   195 GGFGE---------------------------------------VCACQVRATGKMYACKKLEKK 220

Human   261 RIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDE 325
            ||||||||||||||||||||:.|||||||||.||||||||||||||||||||:||||||:|||:|
Mouse   221 RIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGDPGFEE 285

Human   326 QRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVG 390
            .||||||||||||||||||:||||||||||||||||.|||||||||||.|:|||:.|||||||||
Mouse   286 PRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPEGEMVRGRVGTVG 350

Human   391 YMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSED 455
            |||||::|:||||||||||||||||||||.|||||:||||||..||:::|:||:||||||:||||
Mouse   351 YMAPEIINHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREELERRVKNETEEYSERFSED 415

Human   456 AKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDI 520
            |||||.|||.|:|||||||:.:|.:.|||||:||||||.|||||||:|||.|||.|:||:::|||
Mouse   416 AKSICSMLLIKDPSKRLGCQRDGVSAVKQHPIFKDINFSRLEANMLDPPFIPDPQAIYCRNILDI 480

Human   521 EQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK-NIHTP 584
            .|||||||:.|||.||.|||.||||.|:|||||||||||||||:|::|.:.:   .|:| .:.:.
Mouse   481 GQFSVVKGVNLDTNDEIFYAEFATGSVTIPWQNEMIESGCFKDLNENEDDLS---SLEKYKMCSS 542

Human   585 VSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQ 616
            :.||.|.||.|||||.|||.:..|| |.||.:
Mouse   543 ILRPKRNFFRRLFRRTGCLNIALSE-EREPTE 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK4	XP_011511749.1	RGS	52..184	CDD:470619	87/131 (66%)
		STKc_GRK4	186..509	CDD:173720	242/322 (75%)
Grk4	NP_062370.2	N-terminal	1..153		100/152 (66%)
		RGS	51..183	CDD:470619	87/131 (66%)
		STKc_GRK4_like	185..469	CDD:270756	242/322 (75%)