DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ddx54 and CG32344

DIOPT Version :9

Sequence 1:	NP_775375.1	Gene:	ddx54 / 286777	ZFINID:	ZDB-GENE-021220-2	Length:	862	Species:	Danio rerio
Sequence 2:	NP_612028.4	Gene:	CG32344 / 326208	FlyBaseID:	FBgn0052344	Length:	827	Species:	Drosophila melanogaster

Alignment Length:	878	Identity:	366/878 - (41%)
Similarity:	517/878 - (58%)	Gaps:	121/878 - (13%)

- Green bases have known domain annotations that are detailed below.

Zfish    46 LPRFPA--SSECVSDVELDTRELVRAQNKKKKKSGGFQSMGLSYPVYKGIMKKGYKVPTPIQRKT 108
            :|.||:  :....||...|    :.....||.||||||||||.:.:.|||.|:||||||||||||
  Fly     9 IPGFPSLDNDAGTSDRGAD----ILKSKSKKNKSGGFQSMGLGFELIKGITKRGYKVPTPIQRKT 69

Zfish   109 IPVILDGKDVVAMARTGSGKTAAFLVPLFEKLKAPQAQTGARALILTPTRELALQTMKFTKELGK 173
            ||:||:|:||||||:|||||||.||:||||||:..:...|||||||:||||||:||.||.||||:
  Fly    70 IPLILEGRDVVAMAKTGSGKTACFLIPLFEKLQRREPTKGARALILSPTRELAVQTYKFIKELGR 134

Zfish   174 FTGLRTALILGGDSMDDQFAALHENPDIIIGTPGRLMHVIQEMNLKLQSVEYVVFDEADRLFEMG 238
            |..|::.|:|||||||.||:|:|..||:|:.||||.:|:..||:|||.|:|||||||||||||||
  Fly   135 FMELKSILVLGGDSMDSQFSAIHTCPDVIVATPGRFLHLCVEMDLKLNSIEYVVFDEADRLFEMG 199

Zfish   239 FAEQLQEIIRRLPDARQTLLFSATLPKLIVEFARAGLTEPVLIRLDVDTKLSEQLKLSFFSLRLD 303
            |.|||.|.:.|||.:|||::||||||||:||||||||.:||||||||::||.:.|.|.|...|.|
  Fly   200 FGEQLNETLHRLPSSRQTVMFSATLPKLLVEFARAGLNDPVLIRLDVESKLPDALALKFLYCRPD 264

Zfish   304 DKPALLLHLLRNVVKPQEQTVVFVATKHHVEYLKELLSAEGVDCSCIYSALDQTARKISIGRFVH 368
            |:...|:.||:.|:..|.|||||..|:||||.:..:|:..|:..:.:||:||..||||:..:||:
  Fly   265 DRYTALVVLLKYVIPVQSQTVVFAGTQHHVELISYILTEAGISNASVYSSLDPAARKINTAKFVN 329

Zfish   369 RKVMLLLVTDVAARGIDIPLLDNVINYNFPCKPKLFLHRVGRVARAGRGGTAYSLVCPDEVPYLY 433
            :||.:|:||||||||||||.||.|:|.:||.|||||:|||||.|||||.|||||:|..|:..:|.
  Fly   330 KKVSVLIVTDVAARGIDIPSLDFVVNLHFPGKPKLFVHRVGRCARAGRTGTAYSIVSTDDTAHLL 394

Zfish   434 DLHLFLGRPMQLAHPEHTQEADGVFGRVPQSVLDDEECQLITAHQNSLDLQNLRRVSENAYKQYL 498
            ||||||.||..:    |...|   .|.:||.:|::|.. .:|..:.|..:..:.|.||||||:||
  Fly   395 DLHLFLNRPFNI----HDSSA---LGTIPQDLLEEEHL-TVTDIKKSHHIAGVLRTSENAYKKYL 451

Zfish   499 KSRPVPSAESIKRSRNTQLTDMAVHPL--------------------------LGCGLEKMELDR 537
            .||||.|.::  .:|..::...|:.||                          :.....|::.::
  Fly   452 SSRPVASTDA--NARVKKIKFFALKPLEDFFTAAPVLAQAAEASGQSTESQAKVSAAERKLQEEK 514

Zfish   538 LLMVDTIKGYKAKSTIFEINSSNKTSASEVMRAKRSRDRQRVEKFSRARAELRAEPGAGLRAEPP 602
            ..::..::.::...|:||:|::.|::...||:.||.:..:.:.||.:.|||
  Fly   515 HDILVKMRSFRPGGTVFELNTTQKSTQFIVMKEKRMQHAEVINKFRQQRAE-------------- 565

Zfish   603 VHRETQEEDEE-----------------EQEELSTVFSEVVGGKR-RRPDA----EPHTHKSKKS 645
                 ::.|||                 ::|.:|:.|::||..|| :..||    :|   |.||.
  Fly   566 -----EDIDEEKKTIEALNPSSGRMPTADEEAISSTFNKVVAPKRLQNMDALYKDKP---KKKKR 622

Zfish   646 RTAGRDQEFYIPYRPKDFNSERGLSLDSGAGSFEQQASSAVLDLIGDESNTLNQHK-SLMKWDRK 709
            :...:|::.|:||:..|.::|.||:::    :||:||.:|...:...:.:...:|| .|.||||.
  Fly   623 KINSKDEDHYVPYQSADKHTEDGLAIN----NFERQAQNAEFSVSDRDLSQEVKHKPGLKKWDRI 683

Zfish   710 KKRFVRDTGKEDKHKKIRTESGQLIRGHKKKKSFYEEWKKKYKVEGGASDSDGEGGGAQRGRGSA 774
            ||:.|  :.::.:..|||||||..|.. ..|...|.|||:|.|:|.            |..|.:|
  Fly   684 KKKMV--SVQDPRANKIRTESGAWIPA-SFKTGRYAEWKEKSKIED------------QLQRENA 733

Zfish   775 GRRGRGRGRSAAGSQATPAQHQGGSGVRSELKNR-----------QQILKQRKRKAKQQFLQSGG 828
            |.... ..:..:.:|..|........::.|||.|           :||:|.|.|   .:|::...
  Fly   734 GSDDE-NAKPLSHAQRYPVSRHARHNLKLELKKRLTGNDKEMRRPEQIVKSRMR---LEFIKKRN 794

Zfish   829 MKKLRNKGKQRLREVMKSGFGRGAVKKGKMRKK 861
            .:....|.:.|.|.:.|:...:.....|..|:|
  Fly   795 EENAERKSENRKRSMRKTQRPKAQSTGGSKRRK 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ddx54	NP_775375.1	DEADc	80..282	CDD:238167	142/201 (71%)
		DEXDc	95..282	CDD:214692	133/186 (72%)
		HELICc	303..423	CDD:238034	69/119 (58%)
		DBP10CT	688..750	CDD:285373	23/62 (37%)
CG32344	NP_612028.4	DEADc	41..243	CDD:238167	142/201 (71%)
		DEXDc	54..243	CDD:214692	134/188 (71%)
		HELICc	263..384	CDD:238034	69/120 (58%)
		DBP10CT	666..721	CDD:285373	23/57 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576820
Domainoid	1	1.000	239	1.000	Domainoid score	I2234
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5590
Inparanoid	1	1.050	601	1.000	Inparanoid score	I919
OMA	1	1.010	-	-		QHG52023
OrthoDB	1	1.010	-	-		D255924at33208
OrthoFinder	1	1.000	-	-		FOG0004971
OrthoInspector	1	1.000	-	-		oto38863
orthoMCL	1	0.900	-	-		OOG6_101760
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R289
SonicParanoid	1	1.000	-	-		X3504
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940