DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P2RY8 and Aplnr

DIOPT Version :9

Sequence 1:	XP_006724506.2	Gene:	P2RY8 / 286530	HGNCID:	15524	Length:	548	Species:	Homo sapiens
Sequence 2:	NP_112639.1	Gene:	Aplnr / 83518	RGDID:	621645	Length:	377	Species:	Rattus norvegicus

Alignment Length:	351	Identity:	90/351 - (25%)
Similarity:	150/351 - (42%)	Gaps:	51/351 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   215 LPVVYSLVAAVSIPGNLFSLW-VLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHW 278
            :|.:|.||..:...||...|| |.......|..:.||:.:|:|.||.....||....|......|
  Rat    29 IPAIYILVFLLGTTGNGLVLWTVFWSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYREFDW 93

Human   279 VFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTA 343
            .||...|.:.:...:.|||:|:..:|.:|.:|:|.::.|:::.|.|.|.....|.|..|:|....
  Rat    94 PFGTFSCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALL 158

Human   344 LSPL---ARTDL--------TYPVHALGIITCFDVLKWTMLPSVAMWAVFLFTIFILLFLIPFVI 397
            ..|:   ..||:        .|..::: :.|......|.:...|:..||.        |::||:|
  Rat   159 AVPVMVFRSTDIPENSTKTQCYMDYSM-VATSNSEWAWEVGLGVSSTAVG--------FVVPFII 214

Human   398 TVACY---TATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLF---- 455
            .:.||   ..||....|.|...|..:|||.:.:..|:::.|..|:.|.:.|...:::..|.
  Rat   215 MLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGNLLHWPC 279

Human   456 -YGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRLREYL-----GCRRVPRDTLDTRRESL 514
             :.....:|:....|:|.:|:||:||:|.|....|:......|     ||:..|..:
  Rat   280 DFDSFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRRACTSMLCCDQSGCKGSPHSS-------- 336

Human   515 FSARTTSVRSEAGAHPEGMEGATRPG 540
             ||..::  |.:..|.:|      ||
  Rat   337 -SAEKSA--SYSSGHSQG------PG 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P2RY8	XP_006724506.2	7tm_4	222..>321	CDD:304433	29/99 (29%)
P2RY8	XP_006724506.2	7tm_1	229..482	CDD:278431	72/272 (26%)
Aplnr	NP_112639.1	7tmA_Apelin_R	17..318	CDD:341340	79/297 (27%)
		TM helix 1	29..53	CDD:341340	9/23 (39%)
		TM helix 2	63..84	CDD:341340	8/20 (40%)
		TM helix 3	101..123	CDD:341340	5/21 (24%)
		TM helix 4	146..162	CDD:341340	4/15 (27%)
		TM helix 5	197..220	CDD:341340	8/30 (27%)
		TM helix 6	245..267	CDD:341340	5/21 (24%)
		TM helix 7	286..311	CDD:341340	10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..377		7/36 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910