DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P2RY8 and Hcar2

DIOPT Version :9

Sequence 1:	XP_006724506.2	Gene:	P2RY8 / 286530	HGNCID:	15524	Length:	548	Species:	Homo sapiens
Sequence 2:	NP_109626.1	Gene:	Hcar2 / 80885	MGIID:	1933383	Length:	360	Species:	Mus musculus

Alignment Length:	309	Identity:	82/309 - (26%)
Similarity:	136/309 - (44%)	Gaps:	51/309 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   205 MLRNPAIAVALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQI 269
            :.|:..||..||.|..|.....:.||..:||:.|..:.....|.||:.||:|.|.:|...|||..
Mouse    17 VFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLT 81

Human   270 YYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYP------LSSKRWRRRRY 328
            ..:.:...|.||.:.|.|:......|...||:.:|.::|:|:..|::|      :|:     |..
Mouse    82 DNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISN-----RTA 141

Human   329 AVAACAGTWLLLLTALSPLARTDL------TYPVHALGIITCFDVLKWTMLPSVAMWAVFLFTIF 387
            |:.:|. .|.|.:.....|..|::      .|...:..|  |:: .:|.            ..:|
Mouse   142 AIISCF-LWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSI--CYN-FRWH------------DAMF 190

Human   388 ILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVS 452
            :|.|.:|..|.:.| :..|:..||..:.....:.:||:....||.:.|:.||.|:..|.:
Mouse   191 LLEFFLPLAIILFC-SGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIICFLPSVAVRI----- 249

Human   453 RLFYGKSYYHV------------YKLTLCLSCLNNCLDPFVYYFASREF 489
            |:|:....|:|            :..||..:.:|:.|||.||||:|..|
Mouse   250 RIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSF 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P2RY8	XP_006724506.2	7tm_4	222..>321	CDD:304433	30/104 (29%)
P2RY8	XP_006724506.2	7tm_1	229..482	CDD:278431	69/276 (25%)
Hcar2	NP_109626.1	7tmA_HCAR1-3	25..302	CDD:320329	79/301 (26%)
		TM helix 1	26..52	CDD:320329	9/25 (36%)
		TM helix 2	59..84	CDD:320329	11/24 (46%)
		TM helix 3	97..127	CDD:320329	8/29 (28%)
		TM helix 4	139..161	CDD:320329	6/22 (27%)
		TM helix 5	182..211	CDD:320329	8/42 (19%)
		TM helix 6	221..251	CDD:320329	9/34 (26%)
		TM helix 7	270..295	CDD:320329	10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910