DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P2RY8 and P2ry12

DIOPT Version :9

Sequence 1:	XP_006724506.2	Gene:	P2RY8 / 286530	HGNCID:	15524	Length:	548	Species:	Homo sapiens
Sequence 2:	NP_001343936.1	Gene:	P2ry12 / 70839	MGIID:	1918089	Length:	347	Species:	Mus musculus

Alignment Length:	375	Identity:	85/375 - (22%)
Similarity:	150/375 - (40%)	Gaps:	68/375 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   190 MQVP-------NST-GPDNATLQMLRNPAIAVALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSP 246
            |.||       |:| .|..:||.:.......|..|::|:::....:..|..::.:.. ::..:|.
Mouse     1 MDVPGVNTTSANTTFSPGTSTLCVRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFF-QIRSKSN 64

Human   247 SVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVERF 311
            .:||:.|..::||::....||:|.............|:|.|.:|.||..||.||..:..|:::|:
Mouse    65 FIIFLKNTVISDLLMILTFPFKILSDAKLGAGPLRTLVCQVTSVTFYFTMYISISFLGLITIDRY 129

Human   312 LGVLYPLSSKRWRRRRYAVAACAGTWL---------LLLTALSPLARTDLTYPVHALGIITCFDV 367
            |....|..:........|.......|.         ::||...|..:                ||
Mouse   130 LKTTRPFKTSSPSNLLGAKILSVVIWAFMFLISLPNMILTNRRPKDK----------------DV 178

Human   368 LKWTMLPSV--AMWAVFLFTIFILLFLIPFVITVACYTATILKLLRT---EEAHGREQRRRAVGL 427
            .|.:.|.|.  .:|...:..|..::|.|.|:|.:.||:....:|.|:   .....:..:::....
Mouse   179 TKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKVPKKKVNVK 243

Human   428 AAVVLLAFVTCFAPNNFVLLAHIVSR------------LFYGKSYYHVYKLTLCLSCLNNCLDPF 480
            ..:::..|..||.|.:|..:.:.:|:            |||      |.:.||.|:.||.|||||
Mouse   244 VFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCSAENTLFY------VKESTLWLTSLNACLDPF 302

Human   481 VYYFASREFQLRLREYLGCRRVPRDTLDTRRESLFSARTTSVRSEAGAHP 530
            :|:|..:.|:..|...|.|           ..|..::.|...:.:.|..|
Mouse   303 IYFFLCKSFRNSLTSMLRC-----------SNSTSTSGTNKKKGQEGGEP 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P2RY8	XP_006724506.2	7tm_4	222..>321	CDD:304433	24/98 (24%)
P2RY8	XP_006724506.2	7tm_1	229..482	CDD:278431	64/278 (23%)
P2ry12	NP_001343936.1	7tmA_P2Y12	32..315	CDD:341326	70/305 (23%)
		TM helix 1	34..58	CDD:341326	3/24 (13%)
		TM helix 2	66..87	CDD:341326	7/20 (35%)
		TM helix 3	104..126	CDD:341326	9/21 (43%)
		TM helix 4	149..165	CDD:341326	1/15 (7%)
		TM helix 5	193..216	CDD:341326	6/22 (27%)
		TM helix 6	241..263	CDD:341326	5/21 (24%)
		TM helix 7	283..308	CDD:341326	15/30 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..347		5/32 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910