DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P2RY8 and Gpr35

DIOPT Version :9

Sequence 1:	XP_006724506.2	Gene:	P2RY8 / 286530	HGNCID:	15524	Length:	548	Species:	Homo sapiens
Sequence 2:	XP_006529840.1	Gene:	Gpr35 / 64095	MGIID:	1929509	Length:	313	Species:	Mus musculus

Alignment Length:	314	Identity:	89/314 - (28%)
Similarity:	137/314 - (43%)	Gaps:	49/314 - (15%)

- Green bases have known domain annotations that are detailed below.

Human   194 NSTGPDNATLQMLRNPAIAVALPVVYS-LVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVT 257
            ||| ..|:||..   ||......::|| |:..:.:..|..:|||.|.||...:.:.|:|.||:|.
Mouse     8 NST-TCNSTLTW---PASVNNFFIIYSALLLVLGLLLNSVALWVFCYRMHQWTETRIYMTNLAVA 68

Human   258 DLMLASVLPFQIY---YHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLS 319
            ||.|...|||.:|   |..:      ...:|.:....:.||.|.||..:|.|:|:|::.|.:||.
Mouse    69 DLCLLCSLPFVLYSLKYSSS------DTPVCQLSQGIYLANRYMSISLVTAIAVDRYVAVRHPLR 127

Human   320 SKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTMLPSVAMWAV--- 381
            ::..|..|.|.|.|...|::::|:|                      |::|.:......:..
Mouse   128 ARELRSPRQAAAVCVALWVIVVTSL----------------------VVRWRLGMQEGGFCFSSQ 170

Human   382 ----FLFTIFILL-FLIPFVITVAC--YTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCF 439
                |..|.|.|| |.:|..|.|.|  ...|:|......:....|..::|..:....|..||.||
Mouse   171 TRRNFSTTAFSLLGFYLPLAIVVFCSLQVVTVLSRRPAADVGQAEATQKATHMVWANLAVFVICF 235

Human   440 APNNFVLLAHI---VSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 490
            .|.:.||...:   ::......::.....:|..||..|.|||...||:.:||||
Mouse   236 LPLHVVLTVQVSLNLNTCAARDTFSRALSITGKLSDTNCCLDAICYYYMAREFQ 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P2RY8	XP_006724506.2	7tm_4	222..>321	CDD:304433	33/101 (33%)
P2RY8	XP_006724506.2	7tm_1	229..482	CDD:278431	72/268 (27%)
Gpr35	XP_006529840.1	7tmA_GPR35-like	41..292	CDD:320292	78/277 (28%)
		TM helix 2	59..80	CDD:320292	11/20 (55%)
		TM helix 3	94..116	CDD:320292	7/21 (33%)
		TM helix 4	139..155	CDD:320292	6/37 (16%)
		TM helix 5	174..197	CDD:320292	10/22 (45%)
		TM helix 6	218..243	CDD:320292	8/24 (33%)
		TM helix 7	260..285	CDD:320292	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910