DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P2RY8 and Gpr183

DIOPT Version :9

Sequence 1:	XP_006724506.2	Gene:	P2RY8 / 286530	HGNCID:	15524	Length:	548	Species:	Homo sapiens
Sequence 2:	NP_898852.2	Gene:	Gpr183 / 321019	MGIID:	2442034	Length:	357	Species:	Mus musculus

Alignment Length:	312	Identity:	80/312 - (25%)
Similarity:	152/312 - (48%)	Gaps:	47/312 - (15%)

- Green bases have known domain annotations that are detailed below.

Human   213 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHH 277
            |.:|:.||||..:.:.|||.:|.|:.:.....:.:.::.:||.::|::..:.||.:|.|:.....
Mouse    28 VLMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSMNLVISDILFTTALPTRIAYYALGFD 92

Human   278 WVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLT 342
            |..|..||.|..:.||.|.|:.:..|||:|::||..|::||...:.:|..||...|...|:|:..
Mouse    93 WRIGDALCRVTALVFYINTYAGVNFMTCLSIDRFFAVVHPLRYNKIKRIEYAKGVCLSVWILVFA 157

Human   343 ALSPLART-------DLTYPVHALGIITCFDV--------LKWTMLPSVAMWAVFLFTIFILLFL 392
            ...||..|       |.|         ||.:.        |.|.:|.:.           :|.::
Mouse   158 QTLPLLLTPMSKEEGDKT---------TCMEYPNFEGTASLPWILLGAC-----------LLGYV 202

Human   393 IPFVITVACYTATILKLLRTEEAHGREQR----RRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSR 453
            :|..:.:.||:....||.||.:.:...::    ::|:....::::.|:.||.|.:..::.|::..
Mouse   203 LPITVILLCYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFILCFTPYHVAIIQHMIKM 267

Human   454 LFYGKSY----YHVYKL----TLCLSCLNNCLDPFVYYFASREFQLRLREYL 497
            |....:.    .|.:::    |:||...|.|:|||:|:||.:.::.::.:.|
Mouse   268 LCSPGALECGARHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMKML 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P2RY8	XP_006724506.2	7tm_4	222..>321	CDD:304433	31/98 (32%)
P2RY8	XP_006724506.2	7tm_1	229..482	CDD:278431	70/279 (25%)
Gpr183	NP_898852.2	7tmA_EBI2	28..315	CDD:320287	79/306 (26%)
		TM helix 1	30..54	CDD:320287	10/23 (43%)
		TM helix 2	63..84	CDD:320287	5/20 (25%)
		TM helix 3	101..123	CDD:320287	8/21 (38%)
		Interaction with G proteins. /evidence=ECO:0000250	122..130		3/7 (43%)
		TM helix 4	146..162	CDD:320287	3/15 (20%)
		TM helix 5	190..213	CDD:320287	5/33 (15%)
		TM helix 6	239..261	CDD:320287	4/21 (19%)
		TM helix 7	283..308	CDD:320287	10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910