Protein Alignment P2RY8 and P2ry10b

DIOPT Version :9

• Sequence 1: XP_006724506.2
• Gene: P2RY8 / 286530
• HGNCID: 15524
• Length: 548
• Species: Homo sapiens
• Sequence 2: NP_001116067.1
• Gene: P2ry10b / 213438
• MGIID: 2441814
• Length: 352
• Species: Mus musculus
• Alignment Length: 330
• Identity: 113/330 - (34%)
• Similarity: 167/330 - (50%)
• Gaps: 52/330 - (15%)

Human   219 YSLVAA----VSIPG---NLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRH 276
            |||.|.    :.|||   |..:||||||.:..::.::||||||||.||.....||.:|||:.||
Mouse    22 YSLYATTYIFIFIPGLLANSVALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYINR- 85

Human   277 HWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLL 341
            ||.|...||.:.....|.|||:||..:||||::|.|.:|.|..::.| :|||.||..|..|:::.
Mouse    86 HWPFQRALCLLCFYLKYLNMYASIFFLTCISLQRCLFLLKPFRARNW-KRRYDVAISAAVWIIVG 149

Human   342 TALSPLARTDLTYPV-HALGII----TCF------DVLKWTMLPSVAMWAVFLFTIFILLFLIPF 395
            ||..||       |: .:.|:.    :||      |:   ||..|:.|........|:|    |.
Mouse   150 TACLPL-------PILRSAGLANNSESCFADLGLQDI---TMASSIGMVTAAELGGFVL----PV 200

Human   396 VITVACYTATILKLLRTEE-AHGREQRRRAVGLAAVVLLAFVTCFAPN--NFVLLAHIVSRLFYG 457
            ||...|...|...|...:: ....::|::|:.:..:..:.|:.||.|.  ||.....:..|:|..
Mouse   201 VIITYCTWKTRKSLQEFQDPPQNIKERKKALRMVLMCAVVFIVCFTPYHLNFPFFMMVKQRVFSN 265

Human   458 KSY------YHVYKLTLCLSCLNNCLDPFVYYFASREFQLRLREY-----LGCRRVPRDTLD--T 509
            .|:      :|:  ::|||:.||.||||.||||.:.||:.:..|:     ..|......||:  .
Mouse   266 CSFIRNTLCFHI--ISLCLANLNCCLDPVVYYFMTSEFRDQFSEHGNLVIQSCLHCKDSTLEIRQ 328

Human   510 RRESL 514
            |:|:|
Mouse   329 RKENL 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P2RY8	XP_006724506.2	7tm_4	222..>321	CDD:304433	47/105 (45%)
		7tm_1	229..482	CDD:278431	94/275 (34%)
P2ry10b	NP_001116067.1	7tm_GPCRs	23..304	CDD:421689	105/298 (35%)
		TM helix 1	23..50	CDD:410628	12/26 (46%)
		TM helix 2	57..82	CDD:410628	14/24 (58%)
		TM helix 3	94..124	CDD:410628	13/29 (45%)
		TM helix 4	135..157	CDD:410628	10/28 (36%)
		TM helix 5	184..213	CDD:410628	9/32 (28%)
		TM helix 6	225..255	CDD:410628	8/29 (28%)
		TM helix 7	273..298	CDD:410628	14/26 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910