DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P2RY8 and Sstr4

DIOPT Version :9

Sequence 1:	XP_006724506.2	Gene:	P2RY8 / 286530	HGNCID:	15524	Length:	548	Species:	Homo sapiens
Sequence 2:	NP_033245.2	Gene:	Sstr4 / 20608	MGIID:	105372	Length:	385	Species:	Mus musculus

Alignment Length:	389	Identity:	107/389 - (27%)
Similarity:	168/389 - (43%)	Gaps:	35/389 - (8%)

- Green bases have known domain annotations that are detailed below.

Human   161 PGGAQTASLCLLCQGSWHQLESPGEDPSRMQVPNSTGPDNATLQMLRNPAIAVALPVVYSLVAAV 225
            |.|.:..:.......||    :|.|:.......:.||           .|..|.:..:|:||..|
Mouse     8 PPGVEDTTWTPGINASW----APDEEEEDAMGSDGTG-----------TAGMVTIQCIYALVCLV 57

Human   226 SIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTV 290
            .:.||...::|:.|....::.:.|:::||:|.|.:....:|| :.......||.||.:||..|..
Mouse    58 GLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLS 121

Human   291 AFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYP 355
            ....||::|:..:|.:||:|::.|::||.:..:||...|.....|.||..|....|:|....|.|
Mouse   122 VDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRP 186

Human   356 VHALGIITCFDVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQ 420
            ......:.|  .|.|   |..|..|||:...|:|.||:|.:....||...:.|:.......|.:|
Mouse   187 ARGGEAVAC--NLHW---PHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQ 246

Human   421 RRRA----VGLAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFV 481
            |||:    ..|..:|:..||.|:.|...|.|.:    ||.......|..::|.||..|:|.:|.:
Mouse   247 RRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLN----LFVTSLDATVNHVSLILSYANSCANPIL 307

Human   482 YYFASREFQLRLREYLGCRRVPRDTLDTRRESLFSARTTSVRSEAGAHPEGMEGATRPGLQRQE 545
            |.|.|..|:...:..|..|....:|.....|.......|:::|..||      |...|.|..|:
Mouse   308 YGFLSDNFRRSFQRVLCLRCCLLETTGGAEEEPLDYYATALKSRGGA------GCICPPLPCQQ 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P2RY8	XP_006724506.2	7tm_4	222..>321	CDD:304433	30/98 (31%)
P2RY8	XP_006724506.2	7tm_1	229..482	CDD:278431	77/256 (30%)
Sstr4	NP_033245.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		6/32 (19%)
		7tmA_SSTR4	45..319	CDD:320639	86/283 (30%)
		TM helix 1	46..72	CDD:320639	7/25 (28%)
		TM helix 2	79..105	CDD:320639	7/26 (27%)
		TM helix 3	116..146	CDD:320639	9/29 (31%)
		TM helix 4	158..180	CDD:320639	6/21 (29%)
		TM helix 5	205..234	CDD:320639	10/28 (36%)
		TM helix 6	249..279	CDD:320639	9/29 (31%)
		TM helix 7	287..312	CDD:320639	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910